{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:57:44Z","timestamp":1789109864535,"version":"build-2803163510"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI123253"],"award-info":[{"award-number":["R01 AI123253"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI090901"],"award-info":[{"award-number":["R01 AI090901"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI124029"],"award-info":[{"award-number":["R01 AI124029"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21 AI142885"],"award-info":[{"award-number":["R21 AI142885"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI121196"],"award-info":[{"award-number":["R01 AI121196"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Akt-1 and Akt-2 are the major isoforms of the serine\/threonine Akt family that play a key role in controlling immune responses. However, the involvement of Akt-1 and Akt-2 isoforms in antifungal innate immunity is completely unknown. In this study, we show that Akt2\u2212\/\u2212, but not Akt1\u2212\/\u2212, mice are protected from lethal Candida albicans infection. Loss of Akt-2 facilitates the recruitment of neutrophils and macrophages to the spleen and increases reactive oxygen species expression in these cells. Treating C57BL\/6 mice with a specific inhibitor for Akt-2, but not Akt-1, provides protection from lethal C. albicans infection. Our data demonstrate that Akt-2 inhibits antifungal innate immunity by hampering neutrophil and macrophage recruitment to spleens and suppressing oxidative burst, myeloperoxidase activity, and NETosis. We thus describe a novel role for Akt-2 in the regulation of antifungal innate immunity and unveil Akt-2 as a potential target for the treatment of fungal sepsis.<\/jats:p>","DOI":"10.4049\/jimmunol.2101003","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T17:21:52Z","timestamp":1666286512000},"page":"991-1000","source":"Crossref","is-referenced-by-count":1,"title":["Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis"],"prefix":"10.1093","volume":"209","author":[{"given":"Ling","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Iowa Roy J. and Lucille A. Carver College of Medicine , Iowa City, IA"},{"name":"Department of Microbial Infection and Immunity, The Ohio State University , Columbus, OH"},{"name":"Department of Nephrology, Xiangya Hospital, Central South University , Changsha, Hunan,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Iowa Roy J. and Lucille A. Carver College of Medicine , Iowa City, IA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Iowa Roy J. and Lucille A. Carver College of Medicine , Iowa City, IA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Iowa Roy J. and Lucille A. Carver College of Medicine , Iowa City, IA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University , Columbus, OH"},{"name":"Department of Neurology, The First Hospital of Changsha City, South China University , Changsha, Hunan,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2811-1533","authenticated-orcid":false,"given":"Patrick","family":"Nuro-Gyina","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University , Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijian","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Xiangya Hospital, Central South University , Changsha, Hunan,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0994-0109","authenticated-orcid":false,"given":"Yusen","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital , Columbus, OH"},{"name":"Department of Pediatrics, The Ohio State University College of Medicine , Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Iowa Roy J. and Lucille A. Carver College of Medicine , Iowa City, IA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7783-4423","authenticated-orcid":false,"given":"Wallace Y","family":"Langdon","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, University of Western Australia , Perth, WA,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9523-5296","authenticated-orcid":false,"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Iowa Roy J. and Lucille A. Carver College of Medicine , Iowa City, IA"},{"name":"Department of Microbial Infection and Immunity, The Ohio State University , Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,1]]},"reference":[{"key":"2025021008285722900_r1","doi-asserted-by":"crossref","first-page":"165rv13","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: human fungal infections","volume":"4","author":"Brown","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"2025021008285722900_r2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1126\/science.1222236","article-title":"Tackling human fungal infections","volume":"336","author":"Brown","year":"2012","journal-title":"Science"},{"key":"2025021008285722900_r3","doi-asserted-by":"crossref","first-page":"e1000850","DOI":"10.1371\/journal.ppat.1000850","article-title":"Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the northwest United States","volume":"6","author":"Byrnes","year":"2010","journal-title":"PLoS Pathog."},{"key":"2025021008285722900_r4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijid.2017.08.017","article-title":"Candida auris: an emerging multidrug-resistant pathogen","volume":"63","author":"Sears","year":"2017","journal-title":"Int. J. Infect. Dis."},{"key":"2025021008285722900_r5","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fimmu.2018.00123","article-title":"Regulation of C-type lectin receptor-mediated antifungal immunity","volume":"9","author":"Tang","year":"2018","journal-title":"Front. Immunol."},{"key":"2025021008285722900_r6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-981-15-1580-4_1","article-title":"C-type lectin receptors in antifungal immunity","volume":"1204","author":"Nikolakopoulou","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"2025021008285722900_r7","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/ni.2369","article-title":"C-type lectin receptors orchestrate antifungal immunity","volume":"13","author":"Hardison","year":"2012","journal-title":"Nat. Immunol."},{"key":"2025021008285722900_r8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nri1745","article-title":"Dectin-1: a signalling non-TLR pattern-recognition receptor","volume":"6","author":"Brown","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"2025021008285722900_r9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ni1408","article-title":"Dectin-1 is required for \u03b2-glucan recognition and control of fungal infection","volume":"8","author":"Taylor","year":"2007","journal-title":"Nat. Immunol."},{"key":"2025021008285722900_r10","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.immuni.2010.05.001","article-title":"Dectin-2 recognition of \u03b1-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans","volume":"32","author":"Saijo","year":"2010","journal-title":"Immunity"},{"key":"2025021008285722900_r11","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.immuni.2013.05.017","article-title":"C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection","volume":"39","author":"Zhu","year":"2013","journal-title":"Immunity"},{"key":"2025021008285722900_r12","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.chom.2012.04.008","article-title":"Th17 cells in immunity to Candida albicans","volume":"11","author":"Hern\u00e1ndez-Santos","year":"2012","journal-title":"Cell Host Microbe"},{"key":"2025021008285722900_r13","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.cell.2007.06.009","article-title":"AKT\/PKB signaling: navigating downstream","volume":"129","author":"Manning","year":"2007","journal-title":"Cell"},{"key":"2025021008285722900_r14","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","article-title":"AKT\/PKB signaling: navigating the network","volume":"169","author":"Manning","year":"2017","journal-title":"Cell"},{"key":"2025021008285722900_r15","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.4161\/cc.8.16.9335","article-title":"The Akt kinases: isoform specificity in metabolism and cancer","volume":"8","author":"Gonzalez","year":"2009","journal-title":"Cell Cycle"},{"key":"2025021008285722900_r16","doi-asserted-by":"crossref","first-page":"632","DOI":"10.4049\/jimmunol.1202068","article-title":"T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines fate of inducible regulatory T cells","volume":"191","author":"Qiao","year":"2013","journal-title":"J. Immunol."},{"key":"2025021008285722900_r17","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.4049\/jimmunol.1701204","article-title":"Akt-1 and Akt-2 differentially regulate the development of experimental autoimmune encephalomyelitis by controlling proliferation of thymus-derived regulatory T cells","volume":"202","author":"Ouyang","year":"2019","journal-title":"J. Immunol."},{"key":"2025021008285722900_r18","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1128\/JB.183.10.3211-3223.2001","article-title":"CAP1, an adenylate cyclase-associated protein gene, regulates bud-hypha transitions, filamentous growth, and cyclic AMP levels and is required for virulence of Candida albicans","volume":"183","author":"Bahn","year":"2001","journal-title":"J. Bacteriol."},{"key":"2025021008285722900_r19","doi-asserted-by":"crossref","first-page":"e20182091","DOI":"10.1084\/jem.20182091","article-title":"Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia","volume":"217","author":"Tang","year":"2020","journal-title":"J. Exp. Med."},{"key":"2025021008285722900_r20","doi-asserted-by":"crossref","first-page":"868","DOI":"10.4049\/jimmunol.2100083","article-title":"HECT E3 ubiquitin ligase Nedd4 Is required for antifungal innate immunity","volume":"207","author":"Nuro-Gyina","year":"2021","journal-title":"J. Immunol."},{"key":"2025021008285722900_r21","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/nm.4141","article-title":"Targeting CBLB as a potential therapeutic approach for disseminated candidiasis","volume":"22","author":"Xiao","year":"2016","journal-title":"Nat. Med."},{"key":"2025021008285722900_r22","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/ng.3070","article-title":"Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense","volume":"46","author":"Wirnsberger","year":"2014","journal-title":"Nat. Genet."},{"key":"2025021008285722900_r23","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.4049\/jimmunol.162.7.3819","article-title":"p38 Mitogen-activated protein kinase mediates signal integration of TCR\/CD28 costimulation in primary murine T cells","volume":"162","author":"Zhang","year":"1999","journal-title":"J. Immunol."},{"key":"2025021008285722900_r24","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.celrep.2014.01.012","article-title":"E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation","volume":"6","author":"Qiao","year":"2014","journal-title":"Cell Rep."},{"key":"2025021008285722900_r25","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.mib.2008.05.011","article-title":"Fungal killing by mammalian phagocytic cells","volume":"11","author":"Nicola","year":"2008","journal-title":"Curr. Opin. Microbiol."},{"key":"2025021008285722900_r26","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1189\/jlb.1012544","article-title":"ROS production in phagocytes: why, when, and where?","volume":"94","author":"Dupr\u00e9-Crochet","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"2025021008285722900_r27","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.mib.2009.06.007","article-title":"Nitrosative and oxidative stress responses in fungal pathogenicity","volume":"12","author":"Brown","year":"2009","journal-title":"Curr. Opin. Microbiol."},{"key":"2025021008285722900_r28","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1128\/IAI.67.4.1828-1836.1999","article-title":"Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase","volume":"67","author":"Aratani","year":"1999","journal-title":"Infect. Immun."},{"key":"2025021008285722900_r29","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1182\/blood-2013-04-457671","article-title":"NETosis: how vital is it?","volume":"122","author":"Yipp","year":"2013","journal-title":"Blood"},{"key":"2025021008285722900_r30","doi-asserted-by":"crossref","first-page":"318","DOI":"10.4049\/jimmunol.1502381","article-title":"Integrin cross-talk regulates the human neutrophil response to fungal \u03b2-glucan in the context of the extracellular matrix: a prominent role for VLA3 in the antifungal response","volume":"198","author":"Johnson","year":"2017","journal-title":"J. Immunol."},{"key":"2025021008285722900_r31","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/0300985812469883","article-title":"Getting leukocytes to the site of inflammation","volume":"50","author":"Muller","year":"2013","journal-title":"Vet. Pathol."},{"key":"2025021008285722900_r32","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3389\/fimmu.2012.00263","article-title":"CXCR2: from bench to bedside","volume":"3","author":"Stadtmann","year":"2012","journal-title":"Front. Immunol."},{"key":"2025021008285722900_r33","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/ki.2008.105","article-title":"Effects of epithelial and neutrophil CXCR2 on innate immunity and resistance to kidney infection","volume":"74","author":"Svensson","year":"2008","journal-title":"Kidney Int."},{"key":"2025021008285722900_r34","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1016\/j.celrep.2019.07.068","article-title":"Re-education of tumor-associated macrophages by CXCR2 blockade drives senescence and tumor inhibition in advanced prostate cancer","volume":"28","author":"Di Mitri","year":"2019","journal-title":"Cell Rep."},{"key":"2025021008285722900_r35","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1172\/JCI41649","article-title":"CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow","volume":"120","author":"Eash","year":"2010","journal-title":"J. Clin. Invest."},{"key":"2025021008285722900_r36","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1084\/jem.20052069","article-title":"Neutrophils from p40phox\u2212\/\u2212 mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing","volume":"203","author":"Ellson","year":"2006","journal-title":"J. Exp. Med."},{"key":"2025021008285722900_r37","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1089\/ars.2013.5603","article-title":"NADPH oxidases: a perspective on reactive oxygen species production in tumor biology","volume":"20","author":"Meitzler","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"2025021008285722900_r38","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/cmi.2014.89","article-title":"NADPH oxidases: an overview from structure to innate immunity-associated pathologies","volume":"12","author":"Panday","year":"2015","journal-title":"Cell. Mol. Immunol."},{"key":"2025021008285722900_r39","doi-asserted-by":"crossref","first-page":"30097","DOI":"10.1074\/jbc.273.46.30097","article-title":"p40phox is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase: implication of a protein kinase C-type kinase in the phosphorylation process","volume":"273","author":"Bouin","year":"1998","journal-title":"J. Biol. Chem."},{"key":"2025021008285722900_r40","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1182\/blood-2010-08-300889","article-title":"Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase","volume":"116","author":"Chessa","year":"2010","journal-title":"Blood"},{"key":"2025021008285722900_r41","doi-asserted-by":"crossref","first-page":"136570","DOI":"10.1155\/2013\/136570","article-title":"Study of possible mechanisms involved in the inhibitory effects of coumarin derivatives on neutrophil activity","volume":"2013","author":"Dr\u00e1bikov\u00e1","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"2025021008285722900_r42","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1021\/bi035636s","article-title":"Phosphorylated p40PHOX as a negative regulator of NADPH oxidase","volume":"43","author":"Lopes","year":"2004","journal-title":"Biochemistry"},{"key":"2025021008285722900_r43","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.bbamcr.2011.06.002","article-title":"FoxO transcription factors; regulation by AKT and 14-3-3 proteins","volume":"1813","author":"Tzivion","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"2025021008285722900_r44","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.3389\/fimmu.2017.01088","article-title":"FOXO1 regulates bacteria-induced neutrophil activity","volume":"8","author":"Dong","year":"2017","journal-title":"Front. Immunol."},{"key":"2025021008285722900_r45","doi-asserted-by":"crossref","first-page":"9517","DOI":"10.1073\/pnas.1119038109","article-title":"Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization","volume":"109","author":"Arranz","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025021008285722900_r46","doi-asserted-by":"crossref","first-page":"394","DOI":"10.4049\/jimmunol.1300959","article-title":"Akt2 deficiency protects from acute lung injury via alternative macrophage activation and miR-146a induction in mice","volume":"192","author":"Vergadi","year":"2014","journal-title":"J. Immunol."},{"key":"2025021008285722900_r47","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1128\/IAI.01235-10","article-title":"Protective role of Akt2 in Salmonella enterica serovar Typhimurium-induced gastroenterocolitis","volume":"79","author":"Kum","year":"2011","journal-title":"Infect. Immun."},{"key":"2025021008285722900_r48","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.tibs.2011.03.006","article-title":"The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation","volume":"36","author":"Mendoza","year":"2011","journal-title":"Trends Biochem. Sci."},{"key":"2025021008285722900_r49","doi-asserted-by":"crossref","first-page":"4152","DOI":"10.1128\/MCB.01691-12","article-title":"Cross talk between the Akt and p38\u03b1 pathways in macrophages downstream of Toll-like receptor signaling","volume":"33","author":"McGuire","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"2025021008285722900_r50","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1128\/MCB.26.6.2327-2336.2006","article-title":"CARMA1 is required for Akt-mediated NF-\u03baB activation in T cells","volume":"26","author":"Narayan","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"2025021008285722900_r51","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1002\/ijc.24748","article-title":"Akt-mediated regulation of NF\u03baB and the essentialness of NF\u03baB for the oncogenicity of PI3K and Akt","volume":"125","author":"Bai","year":"2009","journal-title":"Int. J. Cancer"},{"key":"2025021008285722900_r52","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1042\/bj20031450","article-title":"Multiple elements regulate nuclear\/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms","volume":"378","author":"Zhao","year":"2004","journal-title":"Biochem. J."},{"key":"2025021008285722900_r53","doi-asserted-by":"crossref","first-page":"7410","DOI":"10.1038\/sj.onc.1209086","article-title":"FOXO transcription factors at the interface between longevity and tumor suppression","volume":"24","author":"Greer","year":"2005","journal-title":"Oncogene"},{"key":"2025021008285722900_r54","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.3389\/fimmu.2019.02530","article-title":"Mucosal immunity and the FOXO1 yranscription factors","volume":"10","author":"Graves","year":"2019","journal-title":"Front. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/209\/5\/991\/61467701\/ji2101003.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/209\/5\/991\/61467701\/ji2101003.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T08:29:15Z","timestamp":1739176155000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/209\/5\/991\/7927370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2101003","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,9]]},"published":{"date-parts":[[2022,9,1]]}}}