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In T cells, stringent regulation of the activity of this second messenger maintains an appropriate balance between effector function and anergy. In this article, we demonstrate that DGK\u03b1 is an indispensable regulator of TCR-mediated activation of CD8 T cells in lymphocytic choriomeningitis virus Clone 13 viral infection. In the absence of DGK\u03b1, Clone 13 infection in a murine model results in a pathologic, proinflammatory state and a multicellular immunopathologic host death that is predominantly driven by CD8 effector T cells.<\/jats:p>","DOI":"10.4049\/jimmunol.2101011","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T15:27:46Z","timestamp":1678894066000},"page":"1281-1291","source":"Crossref","is-referenced-by-count":3,"title":["Lymphocytic Choriomeningitis Virus Clone 13 Infection Results in CD8 T Cell\u2013Mediated Host Mortality in Diacylglycerol Kinase \u03b1\u2013Deficient Mice"],"prefix":"10.1093","volume":"210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4140-6707","authenticated-orcid":false,"given":"Matthew R","family":"Kudek","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology, Oncology, and BMT, Department of Pediatrics, Medical College of Wisconsin , Milwaukee, WI"},{"name":"Versiti Blood Research Institute , Milwaukee, WI"},{"name":"Department of Microbiology and Immunology, Medical College of Wisconsin , Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Xin","sequence":"additional","affiliation":[{"name":"Versiti Blood Research Institute , Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5033-3696","authenticated-orcid":false,"given":"Donia","family":"Alson","sequence":"additional","affiliation":[{"name":"Versiti Blood Research Institute , Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Holzhauer","sequence":"additional","affiliation":[{"name":"Versiti Blood Research Institute , Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8398-2318","authenticated-orcid":false,"given":"Jian","family":"Shen","sequence":"additional","affiliation":[{"name":"Versiti Blood Research Institute , Milwaukee, WI"},{"name":"Department of Microbiology and Immunology, Medical College of Wisconsin , Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5753-5335","authenticated-orcid":false,"given":"Moujtaba Y","family":"Kasmani","sequence":"additional","affiliation":[{"name":"Versiti Blood Research Institute , Milwaukee, WI"},{"name":"Department of Microbiology and Immunology, Medical College of Wisconsin , Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Riese","sequence":"additional","affiliation":[{"name":"Versiti Blood Research Institute , Milwaukee, WI"},{"name":"Division of Oncology, Department of Medicine, Medical College of Wisconsin , Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1562-9218","authenticated-orcid":false,"given":"Weiguo","family":"Cui","sequence":"additional","affiliation":[{"name":"Versiti Blood Research Institute , Milwaukee, WI"},{"name":"Department of Microbiology and Immunology, Medical College of Wisconsin , Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,5]]},"reference":[{"key":"2025021008040565100_r1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.pupt.2012.06.005","article-title":"Regulation of GPCR-mediated smooth muscle contraction: implications for asthma and pulmonary hypertension","volume":"26","author":"Wright","year":"2013","journal-title":"Pulm. 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