{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:45:02Z","timestamp":1784555102213,"version":"3.55.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"No specific founding has been recived"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Despite measures taken world-wide, the coronavirus disease 2019 (COVID-19) pandemic continues. Because efficient antiviral drugs are not yet widely available, vaccination is the best option to control the infection rate. Although this option is obvious in the case of COVID-19\u2013naive individuals, it is still unclear when individuals who have recovered from a previous SARS-CoV-2 infection should be vaccinated and whether the vaccination raises immune responses against the coronavirus and its novel variants. In this study, we collected peripheral blood from 84 healthy human donors of different COVID-19 status who were vaccinated with the Sputnik Light vaccine and measured the dynamics of the Ab and T cell responses, as well as the virus-neutralizing activity (VNA) in serum, against two SARS-CoV-2 variants, B.1.1.1 and B.1.617.2. We showed that vaccination of individuals previously exposed to the virus considerably boosts the existing immune response. In these individuals, receptor-binding domain (RBD)\u2013specific IgG titers and VNA in serum were already elevated on the 7th day after vaccination, whereas COVID-19\u2013naive individuals developed the Ab response and VNA mainly 21 d postvaccination. Additionally, we found a strong correlation between RBD-specific IgG titers and VNA in serum, and according to these data vaccination may be recommended when the RBD-specific IgG titers drop to 142.7 binding Ab units\/ml or below. In summary, the results of the study demonstrate that vaccination is beneficial for both COVID-19\u2013naive and recovered individuals, especially since it raises serum VNA against the B.1.617.2 variant, one of the five SARS-CoV-2 variants of concern.<\/jats:p>","DOI":"10.4049\/jimmunol.2101052","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T11:50:18Z","timestamp":1643629818000},"page":"1139-1145","source":"Crossref","is-referenced-by-count":15,"title":["Boosting of the SARS-CoV-2\u2013Specific Immune Response after Vaccination with Single-Dose Sputnik Light Vaccine"],"prefix":"10.1093","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1018-5195","authenticated-orcid":false,"given":"Alexey A","family":"Komissarov","sequence":"first","affiliation":[{"name":"Clinical City Hospital named after I.V. Davydovsky, Moscow Department of Healthcare , Moscow,","place":["Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2548-6142","authenticated-orcid":false,"given":"Inna V","family":"Dolzhikova","sequence":"additional","affiliation":[{"name":"Federal State Budget Institution National Research Centre for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Health of the Russian Federation , Moscow,","place":["Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7129-6062","authenticated-orcid":false,"given":"Grigory A","family":"Efimov","sequence":"additional","affiliation":[{"name":"National Research Center for Hematology , Moscow,","place":["Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis Y","family":"Logunov","sequence":"additional","affiliation":[{"name":"Federal State Budget Institution National Research Centre for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Health of the Russian Federation , Moscow,","place":["Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9252-1601","authenticated-orcid":false,"given":"Olga","family":"Mityaeva","sequence":"additional","affiliation":[{"name":"Genome Engineering Laboratory, Moscow Institute of Physics and Technology , Dolgoprudniy,","place":["Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan A","family":"Molodtsov","sequence":"additional","affiliation":[{"name":"Clinical City Hospital named after I.V. Davydovsky, Moscow Department of Healthcare , Moscow,","place":["Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelli B","family":"Naigovzina","sequence":"additional","affiliation":[{"name":"A.I. Yevdokimov Moscow State University of Medicine and Dentistry , Moscow,","place":["Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3833-3380","authenticated-orcid":false,"given":"Iuliia O","family":"Peshkova","sequence":"additional","affiliation":[{"name":"National Research Center for Hematology , Moscow,","place":["Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry V","family":"Shcheblyakov","sequence":"additional","affiliation":[{"name":"Federal State Budget Institution National Research Centre for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Health of the Russian Federation , Moscow,","place":["Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9794-6297","authenticated-orcid":false,"given":"Pavel","family":"Volchkov","sequence":"additional","affiliation":[{"name":"Genome Engineering Laboratory, Moscow Institute of Physics and Technology , Dolgoprudniy,","place":["Russia"]},{"name":"Research Institute of Personalized Medicine, National Center for Personalized Medicine of Endocrine Diseases, The National Medical Research Center for Endocrinology , Moscow,","place":["Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander L","family":"Gintsburg","sequence":"additional","affiliation":[{"name":"Federal State Budget Institution National Research Centre for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Health of the Russian Federation , Moscow,","place":["Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Vasilieva","sequence":"additional","affiliation":[{"name":"Clinical City Hospital named after I.V. Davydovsky, Moscow Department of Healthcare , Moscow,","place":["Russia"]},{"name":"A.I. Yevdokimov Moscow State University of Medicine and Dentistry , Moscow,","place":["Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,1]]},"reference":[{"key":"2025021008554666500_r1","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(21)00575-4","article-title":"Assessment of protection against reinfection with SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020: a population-level observational study","volume":"397","author":"Hansen","year":"2021","journal-title":"Lancet"},{"key":"2025021008554666500_r2","article-title":"Re-infection with SARS-CoV-2 in patients undergoing serial laboratory testing","author":"Qureshi","year":"2021","journal-title":"Clin. Infect. 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Virol."},{"key":"2025021008554666500_r6","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41586-021-03777-9","article-title":"Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization","volume":"596","author":"Planas","year":"2021","journal-title":"Nature"},{"key":"2025021008554666500_r7","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.1016\/j.cell.2021.06.020","article-title":"Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum","volume":"184","author":"Liu","year":"2021","journal-title":"Cell"},{"key":"2025021008554666500_r8","doi-asserted-by":"crossref","first-page":"100359","DOI":"10.1016\/j.xcrm.2021.100359","article-title":"Sputnik V vaccine elicits seroconversion and neutralizing capacity to SARS-CoV-2 after a single dose","volume":"2","author":"Rossi","year":"2021","journal-title":"Cell Rep. 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Infect."},{"key":"2025021008554666500_r25","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3390\/vaccines9070779","article-title":"Neutralizing activity of sera from Sputnik V-vaccinated people against variants of concern (VOC: B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.3) and Moscow endemic SARS-CoV-2 variants","volume":"9","author":"Gushchin","year":"2021","journal-title":"Vaccines (Basel)"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/208\/5\/1139\/61466471\/ji2101052.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/208\/5\/1139\/61466471\/ji2101052.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T03:56:00Z","timestamp":1739159760000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/208\/5\/1139\/7924487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,3,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2101052","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.10.26.21265531","asserted-by":"object"}]},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,3]]},"published":{"date-parts":[[2022,3,1]]}}}