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Chronic beryllium disease is caused by occupational exposure to beryllium containing particles, whereas the etiology of sarcoidosis is not known. Genetic susceptibility for both diseases is associated with particular MHC class II alleles, and CD4+ T cells are implicated in their pathogenesis. The innate immune system plays a critical role in the initiation of pathogenic CD4+ T cell responses as well as the transition to active lung disease and disease progression. In this review, we highlight recent insights into Ag recognition in chronic beryllium disease and sarcoidosis. In addition, we discuss the current understanding of the dynamic interactions between the innate and adaptive immune systems and their impact on disease pathogenesis.<\/jats:p>","DOI":"10.4049\/jimmunol.2101159","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T19:45:18Z","timestamp":1649879118000},"page":"1835-1843","source":"Crossref","is-referenced-by-count":12,"title":["Innate and Adaptive Immunity in Noninfectious Granulomatous Lung Disease"],"prefix":"10.1093","volume":"208","author":[{"given":"Amy S","family":"McKee","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Colorado Anschutz Medical Campus , Aurora, CO"},{"name":"Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus , Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7928-5365","authenticated-orcid":false,"given":"Shaikh M","family":"Atif","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Anschutz Medical Campus , Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T","family":"Falta","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Anschutz Medical Campus , Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4095-512X","authenticated-orcid":false,"given":"Andrew P","family":"Fontenot","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Anschutz Medical Campus , Aurora, CO"},{"name":"Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus , Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,15]]},"reference":[{"key":"2025021009033505100_r1","doi-asserted-by":"crossref","first-page":"170012","DOI":"10.1183\/16000617.0012-2017","article-title":"Differential diagnosis of granulomatous lung disease: clues and pitfalls: number 4 in the series \u201cPathology for the clinician\u201d edited by Peter Dorfmuller and Alberto Cavazza","volume":"26","author":"Ohshimo","year":"2017","journal-title":"Eur. 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