{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:17:22Z","timestamp":1790738242264,"version":"4.1.0"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U01 AI131337"],"award-info":[{"award-number":["U01 AI131337"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI127695"],"award-info":[{"award-number":["R01AI127695"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K12HD000850"],"award-info":[{"award-number":["K12HD000850"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Marshall Klaus Perinatal Research Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In humans and mice, offspring of allergic mothers are predisposed to development of allergy. In mice, allergic mothers have elevated \u03b2-glucosylceramides (\u03b2GlcCers) that are transported to the fetus via the placenta and to offspring via milk. The elevated \u03b2GlcCers increase the number of fetal liver CD11c+CD11b+ dendritic cells (DCs) and offspring allergen-induced lung eosinophilia. These effects are modifiable by maternal dietary supplementation with the plant-derived lipids \u03b1-tocopherol and \u03b3-tocopherol. It is not known whether \u03b2GlcCers and tocopherols directly regulate development of DCs. In this study, we demonstrated that \u03b2GlcCers increased development of GM-CSF\u2013stimulated mouse bone marrow\u2013derived DCs (BMDCs) in vitro without altering expression of costimulatory molecules. This increase in BMDC numbers was blocked by \u03b1-tocopherol and potentiated by \u03b3-tocopherol. Furthermore, \u03b2GlcCers increased protein kinase C\u03b1 (PKC\u03b1) and PKC\u03b4 activation in BMDCs that was blocked by \u03b1-tocopherol. In contrast, \u03b3-tocopherol increased BMDC PKC\u03b1 and PKC\u03b4 activation and enhanced the \u03b2GlcCer-induced increase in PKC\u03b4 activation in a DC subset. Ag processing per DC was minimally enhanced in \u03b2GlcCer-treated BMDCs and not altered ex vivo in lung DCs from pups of allergic mothers. Pups of allergic mothers had an increased proportion of CD11b+CD11c+ subsets of DCs, contributing to enhanced stimulation of T cell proliferation ex vivo. Thus, \u03b2GlcCer, which is both necessary and sufficient for development of allergic predisposition in offspring of allergic mothers, directly increased development and PKC activation in BMDCs. Furthermore, this was modifiable by dietary tocopherols. This may inform design of future studies for the prevention or intervention in asthma and allergic disease.<\/jats:p>","DOI":"10.4049\/jimmunol.2101188","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T05:02:33Z","timestamp":1672722153000},"page":"1837-1850","source":"Crossref","is-referenced-by-count":12,"title":["\u03b2-Glucosylceramides and Tocopherols Regulate Development and Function of Dendritic Cells"],"prefix":"10.1093","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3386-6292","authenticated-orcid":false,"given":"Jacquelyn D","family":"Lajiness","sequence":"first","affiliation":[{"name":"Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine , Indianapolis, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nansalmaa","family":"Amarsaikhan","sequence":"additional","affiliation":[{"name":"Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine , Indianapolis, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4369-8758","authenticated-orcid":false,"given":"Kiet","family":"Tat","sequence":"additional","affiliation":[{"name":"Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine , Indianapolis, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angar","family":"Tsoggerel","sequence":"additional","affiliation":[{"name":"Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine , Indianapolis, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1564-5218","authenticated-orcid":false,"given":"Joan M","family":"Cook-Mills","sequence":"additional","affiliation":[{"name":"Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine , Indianapolis, IN"},{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine , Indianapolis, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"2025021008422911200_r1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1289\/ehp.9610422","article-title":"The attack of asthma","volume":"104","author":"Friebele","year":"1996","journal-title":"Environ. Health Perspect."},{"key":"2025021008422911200_r2","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1164\/ajrccm.157.4.9704140","article-title":"20-year trends in the prevalence of asthma and chronic airflow obstruction in an HMO","volume":"157","author":"Vollmer","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025021008422911200_r3","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1183\/09031936.05.00019805","article-title":"The prevalence of asthma in children: a reversing trend","volume":"26","author":"van Schayck","year":"2005","journal-title":"Eur. Respir. J."},{"key":"2025021008422911200_r4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0897.2008.00671.x","article-title":"Maternal transmission of asthma risk","volume":"61","author":"Lim","year":"2009","journal-title":"Am. J. Reprod. Immunol."},{"key":"2025021008422911200_r5","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.4049\/jimmunol.170.4.1683","article-title":"Allergen-independent maternal transmission of asthma susceptibility","volume":"170","author":"Hamada","year":"2003","journal-title":"J. Immunol."},{"key":"2025021008422911200_r6","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1600-0897.2007.00496.x","article-title":"Duration of allergic susceptibility in maternal transmission of asthma risk","volume":"58","author":"Fedulov","year":"2007","journal-title":"Am. J. Reprod. Immunol."},{"key":"2025021008422911200_r7","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.4049\/jimmunol.178.3.1477","article-title":"Targeting of CD25 and glucocorticoid-induced TNF receptor family-related gene-expressing T cells differentially modulates asthma risk in offspring of asthmatic and normal mother mice","volume":"178","author":"Hubeau","year":"2007","journal-title":"J. Immunol."},{"key":"2025021008422911200_r8","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.2353\/ajpath.2006.051231","article-title":"Adoptively transferred allergen-specific T cells cause maternal transmission of asthma risk","volume":"168","author":"Hubeau","year":"2006","journal-title":"Am. J. Pathol."},{"key":"2025021008422911200_r9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000053708","article-title":"Allergic sensitization and allergen exposure during pregnancy favor the development of atopy in the neonate","volume":"124","author":"Herz","year":"2001","journal-title":"Int. Arch. Allergy Immunol."},{"key":"2025021008422911200_r10","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1164\/ajrccm.162.supplement_2.ras-1","article-title":"Prenatal sensitization in a mouse model","volume":"162","author":"Herz","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025021008422911200_r11","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/280145a0","article-title":"Selective suppression of IgE antibody responsiveness by maternal influence","volume":"280","author":"Jarrett","year":"1979","journal-title":"Nature"},{"key":"2025021008422911200_r12","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.freeradbiomed.2021.10.037","article-title":"Asthma, allergy and vitamin E: current and future perspectives","volume":"179","author":"Cook-Mills","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"2025021008422911200_r13","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/j.jaci.2018.02.003","article-title":"Mechanism for initiation of food allergy: dependence on skin barrier mutations and environmental allergen costimulation. [Published erratum appears in 2018 J. Allergy Clin. Immunol. 142: 339.]","volume":"141","author":"Walker","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025021008422911200_r14","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40413-017-0141-8","article-title":"Allergic diseases and asthma in pregnancy, a secondary publication","volume":"10","author":"Pali-Sch\u00f6ll","year":"2017","journal-title":"World Allergy Organ. J."},{"key":"2025021008422911200_r15","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00404-018-4800-y","article-title":"Prospective cohort study of pregnancy complications and birth outcomes in women with asthma. [Published erratum appears in 2019 Arch. Gynecol. Obstet. 299: 597.]","volume":"298","author":"Fazel","year":"2018","journal-title":"Arch. Gynecol. Obstet."},{"key":"2025021008422911200_r16","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.4049\/jimmunol.175.7.4292","article-title":"Immunostimulatory CpG oligonucleotides abrogate allergic susceptibility in a murine model of maternal asthma transmission","volume":"175","author":"Fedulov","year":"2005","journal-title":"J. Immunol."},{"key":"2025021008422911200_r17","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1165\/rcmb.2009-0400OC","article-title":"Allergy risk is mediated by dendritic cells with congenital epigenetic changes","volume":"44","author":"Fedulov","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2025021008422911200_r18","doi-asserted-by":"crossref","first-page":"e53242","DOI":"10.1371\/journal.pone.0053242","article-title":"Resident CD11b(+)Ly6C(-) lung dendritic cells are responsible for allergic airway sensitization to house dust mite in mice","volume":"7","author":"Mesnil","year":"2012","journal-title":"PLoS One"},{"key":"2025021008422911200_r19","doi-asserted-by":"crossref","first-page":"L482","DOI":"10.1152\/ajplung.00132.2014","article-title":"\u03b1-Tocopherol supplementation of allergic female mice inhibits development of CD11c+CD11b+ dendritic cells in utero and allergic inflammation in neonates","volume":"307","author":"Abdala-Valencia","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2025021008422911200_r20","doi-asserted-by":"crossref","first-page":"L759","DOI":"10.1152\/ajplung.00301.2015","article-title":"\u03b3-Tocopherol supplementation of allergic female mice augments development of CD11c+CD11b+ dendritic cells in utero and allergic inflammation in neonates","volume":"310","author":"Abdala-Valencia","year":"2016","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2025021008422911200_r21","doi-asserted-by":"crossref","first-page":"e4660","DOI":"10.1371\/journal.pone.0004660","article-title":"Transplacental passage of interleukins 4 and 13?","volume":"4","author":"Lim","year":"2009","journal-title":"PLoS One"},{"key":"2025021008422911200_r22","doi-asserted-by":"crossref","first-page":"762","DOI":"10.4049\/jimmunol.176.2.762","article-title":"Role of breast milk in a mouse model of maternal transmission of asthma susceptibility","volume":"176","author":"Leme","year":"2006","journal-title":"J. Immunol."},{"key":"2025021008422911200_r23","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.4049\/jimmunol.171.7.3485","article-title":"Critical role of preconceptional immunization for protective and nonpathological specific immunity in murine neonates","volume":"171","author":"Uthoff","year":"2003","journal-title":"J. Immunol."},{"key":"2025021008422911200_r24","doi-asserted-by":"crossref","first-page":"647134","DOI":"10.3389\/falgy.2021.647134","article-title":"\u03b2-Glucosylceramide from allergic mothers enhances offspring responsiveness to allergen","volume":"2","author":"Walker","year":"2021","journal-title":"Front. Allergy"},{"key":"2025021008422911200_r25","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.4049\/jimmunol.0803659","article-title":"Isoforms of vitamin E have opposing immunoregulatory functions during inflammation by regulating leukocyte recruitment","volume":"182","author":"Berdnikovs","year":"2009","journal-title":"J. Immunol."},{"key":"2025021008422911200_r26","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1136\/thx.54.11.1021","article-title":"Dietary factors and pulmonary function: a cross sectional study in middle aged men from three European countries","volume":"54","author":"Tabak","year":"1999","journal-title":"Thorax"},{"key":"2025021008422911200_r27","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1017\/S0029665199000427","article-title":"Dietary influences on chronic obstructive lung disease and asthma: a review of the epidemiological evidence","volume":"58","author":"Smit","year":"1999","journal-title":"Proc. Nutr. Soc."},{"key":"2025021008422911200_r28","first-page":"244","article-title":"Diet as a risk factor for asthma","volume":"206","author":"Weiss","year":"1997","journal-title":"Ciba Found. Symp."},{"key":"2025021008422911200_r29","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1164\/ajrccm.151.5.7735592","article-title":"A prospective study of diet and adult-onset asthma","volume":"151","author":"Troisi","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025021008422911200_r30","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1164\/ajrccm.154.5.8912755","article-title":"Does dietary intake of vitamins C and E influence lung function in older people?","volume":"154","author":"Dow","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025021008422911200_r31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000079555","article-title":"Gamma-tocopherol\u2014an underestimated vitamin?","volume":"48","author":"Wagner","year":"2004","journal-title":"Ann. Nutr. Metab."},{"key":"2025021008422911200_r32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1465-9921-15-31","article-title":"The vitamin E isoforms \u03b1-tocopherol and \u03b3-tocopherol have opposite associations with spirometric parameters: the CARDIA study","volume":"15","author":"Marchese","year":"2014","journal-title":"Respir. Res."},{"key":"2025021008422911200_r33","doi-asserted-by":"crossref","first-page":"1000137","DOI":"10.4172\/2155-9899.1000137","article-title":"Isoforms of vitamin E differentially regulate PKC \u03b1 and inflammation: a review","volume":"4","author":"Cook-Mills","year":"2013","journal-title":"J. Clin. Cell. Immunol."},{"key":"2025021008422911200_r34","doi-asserted-by":"crossref","first-page":"e41054","DOI":"10.1371\/journal.pone.0041054","article-title":"Vitamin E isoforms differentially regulate intercellular adhesion molecule-1 activation of PKC\u03b1 in human microvascular endothelial cells","volume":"7","author":"Abdala-Valencia","year":"2012","journal-title":"PLoS One"},{"key":"2025021008422911200_r35","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1042\/BJ20111318","article-title":"Vitamin E isoforms directly bind PKC\u03b1 and differentially regulate activation of PKC\u03b1","volume":"441","author":"McCary","year":"2012","journal-title":"Biochem. J."},{"key":"2025021008422911200_r36","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1038\/s41467-020-15692-0","article-title":"Kinesin-1 regulates antigen cross-presentation through the scission of tubulations from early endosomes in dendritic cells","volume":"11","author":"Belabed","year":"2020","journal-title":"Nat. Commun."},{"key":"2025021008422911200_r37","doi-asserted-by":"crossref","first-page":"101278","DOI":"10.1016\/j.isci.2020.101278","article-title":"Galectin-8 enhances T cell response by promotion of antigen internalization and processing","volume":"23","author":"Prato","year":"2020","journal-title":"iScience"},{"key":"2025021008422911200_r38","doi-asserted-by":"crossref","first-page":"612397","DOI":"10.3389\/fnut.2020.612397","article-title":"A THP-1 cell line-based exploration of immune responses toward heat-treated BLG","volume":"7","author":"Deng","year":"2021","journal-title":"Front. Nutr."},{"key":"2025021008422911200_r39","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1182\/blood-2013-12-545772","article-title":"Selective and efficient generation of functional Batf3-dependent CD103+ dendritic cells from mouse bone marrow","volume":"124","author":"Mayer","year":"2014","journal-title":"Blood"},{"key":"2025021008422911200_r40","doi-asserted-by":"crossref","first-page":"9980","DOI":"10.1016\/S0021-9258(19)50188-0","article-title":"Role of protein kinase C and the Na+\/H+ antiporter in suppression of apoptosis by granulocyte macrophage colony-stimulating factor and interleukin-3","volume":"267","author":"Rajotte","year":"1992","journal-title":"J. Biol. Chem."},{"key":"2025021008422911200_r41","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1046\/j.1365-2567.1998.00614.x","article-title":"Granulocyte-macrophage colony-stimulating factor and interleukin-3 potentiate interferon-gamma-mediated endothelin production by human monocytes: role of protein kinase C","volume":"95","author":"Salh","year":"1998","journal-title":"Immunology"},{"key":"2025021008422911200_r42","first-page":"3237","article-title":"Evidence for distinct intracellular signaling pathways in CD34+ progenitor to dendritic cell differentiation from a human cell line model. [Published erratum appears in 2014 J. Immunol. 173: following 6489.]","volume":"162","author":"St Louis","year":"1999","journal-title":"J. Immunol."},{"key":"2025021008422911200_r43","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/jcp.22312","article-title":"Selective activation of specific PKC isoforms dictating the fate of CD14(+) monocytes towards differentiation or apoptosis","volume":"226","author":"Lin","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"2025021008422911200_r44","doi-asserted-by":"crossref","first-page":"7900","DOI":"10.1128\/MCB.25.17.7900-7916.2005","article-title":"Regulation of RelB expression during the initiation of dendritic cell differentiation","volume":"25","author":"Cejas","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"2025021008422911200_r45","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s12026-009-8118-5","article-title":"Tumor-mediated inhibition of dendritic cell differentiation is mediated by down regulation of protein kinase C beta II expression","volume":"46","author":"Farren","year":"2010","journal-title":"Immunol. Res."},{"key":"2025021008422911200_r46","doi-asserted-by":"crossref","first-page":"5126","DOI":"10.1038\/sj.onc.1202896","article-title":"Association of RACK1 and PKCbeta with the common beta-chain of the IL-5\/IL-3\/GM-CSF receptor","volume":"18","author":"Geijsen","year":"1999","journal-title":"Oncogene"},{"key":"2025021008422911200_r47","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/stem.564","article-title":"PKC\u03b4-induced PU.1 phosphorylation promotes hematopoietic stem cell differentiation to dendritic cells","volume":"29","author":"Hamdorf","year":"2011","journal-title":"Stem Cells"},{"key":"2025021008422911200_r48","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1089\/jir.2007.0007","article-title":"The protein kinase C (PKC) family of proteins in cytokine signaling in hematopoiesis","volume":"27","author":"Redig","year":"2007","journal-title":"J. Interferon Cytokine Res."},{"key":"2025021008422911200_r49","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/S0960-9822(02)70678-7","article-title":"Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase Calpha","volume":"6","author":"Bornancin","year":"1996","journal-title":"Curr. Biol."},{"key":"2025021008422911200_r50","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1042\/bj2940335","article-title":"Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C","volume":"294","author":"Wilkinson","year":"1993","journal-title":"Biochem. J."},{"key":"2025021008422911200_r51","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/S0022-3565(25)39027-0","article-title":"Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation","volume":"268","author":"Birchall","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2025021008422911200_r52","doi-asserted-by":"crossref","first-page":"5558","DOI":"10.1021\/bi9731807","article-title":"Cross-talk between protein kinase C-alpha (PKC-alpha) and -delta (PKC-delta): PKC-alpha elevates the PKC-delta protein level, altering its mRNA transcription and degradation","volume":"37","author":"Romanova","year":"1998","journal-title":"Biochemistry"},{"key":"2025021008422911200_r53","doi-asserted-by":"crossref","first-page":"11114","DOI":"10.1073\/pnas.191369098","article-title":"Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC","volume":"98","author":"Chen","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025021008422911200_r54","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1186\/s12974-018-1342-y","article-title":"Protein kinase C-delta inhibition protects blood-brain barrier from sepsis-induced vascular damage","volume":"15","author":"Tang","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"2025021008422911200_r55","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1124\/dmd.111.040725","article-title":"Distribution of KAI-9803, a novel \u03b4-protein kinase C inhibitor, after intravenous administration to rats","volume":"39","author":"Miyaji","year":"2011","journal-title":"Drug Metab. Dispos."},{"key":"2025021008422911200_r56","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1038\/ncomms3990","article-title":"Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation","volume":"4","author":"Williams","year":"2013","journal-title":"Nat. Commun."},{"key":"2025021008422911200_r57","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1084\/jem.20171163","article-title":"Maternal IgG immune complexes induce food allergen-specific tolerance in offspring","volume":"215","author":"Ohsaki","year":"2018","journal-title":"J. Exp. Med."},{"key":"2025021008422911200_r58","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.anai.2019.04.022","article-title":"Immunomodulatory effects of breast milk on food allergy","volume":"123","author":"J\u00e4rvinen","year":"2019","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"2025021008422911200_r59","doi-asserted-by":"crossref","first-page":"6460","DOI":"10.4049\/jimmunol.177.9.6460","article-title":"IL-12 contributes to allergen-induced airway inflammation in experimental asthma","volume":"177","author":"Meyts","year":"2006","journal-title":"J. Immunol."},{"key":"2025021008422911200_r60","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.4049\/jimmunol.166.4.2741","article-title":"IL-12-dependent vascular cell adhesion molecule-1 expression contributes to airway eosinophilic inflammation in a mouse model of asthma-like reaction","volume":"166","author":"Wang","year":"2001","journal-title":"J. Immunol."},{"key":"2025021008422911200_r61","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1067\/mai.2000.105526","article-title":"Comparison of allergen-stimulated dendritic cells from atopic and nonatopic donors dissecting their effect on autologous naive and memory T helper cells of such donors","volume":"105","author":"Bellinghausen","year":"2000","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025021008422911200_r62","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1046\/j.1365-3083.1999.00462.x","article-title":"Efficient presentation of house dust mite allergen Der p 2 by monocyte-derived dendritic cells and the role of beta 2 integrins","volume":"49","author":"Sung","year":"1999","journal-title":"Scand. J. Immunol."},{"key":"2025021008422911200_r63","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1615\/CritRevOncog.2013004503","article-title":"Immunological cells and functions in Gaucher disease","volume":"18","author":"Pandey","year":"2013","journal-title":"Crit. Rev. Oncog."},{"key":"2025021008422911200_r64","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1152\/physrev.00034.2007","article-title":"Structural basis of protein kinase C isoform function","volume":"88","author":"Steinberg","year":"2008","journal-title":"Physiol. Rev."},{"key":"2025021008422911200_r65","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.4049\/jimmunol.160.8.3689","article-title":"Phorbol esters induce differentiation of human CD34+ hemopoietic progenitors to dendritic cells: evidence for protein kinase C-mediated signaling","volume":"160","author":"Davis","year":"1998","journal-title":"J. Immunol."},{"key":"2025021008422911200_r66","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.immuni.2011.11.015","article-title":"Syk kinase-coupled C-type lectin receptors engage protein kinase C-\u03b4 to elicit Card9 adaptor-mediated innate immunity","volume":"36","author":"Strasser","year":"2012","journal-title":"Immunity"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/209\/10\/1837\/61468349\/ji2101188.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/209\/10\/1837\/61468349\/ji2101188.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T08:44:49Z","timestamp":1739177089000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/209\/10\/1837\/7959032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":66,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,11,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2101188","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,11]]},"published":{"date-parts":[[2022,11]]}}}