{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T21:37:21Z","timestamp":1787693841911,"version":"build-2784847793"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630058"],"award-info":[{"award-number":["81630058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570211"],"award-info":[{"award-number":["81570211"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31670904"],"award-info":[{"award-number":["31670904"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91542107"],"award-info":[{"award-number":["91542107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Carma3 is an intracellular scaffolding protein that can form complex with Bcl10 and Malt1 to mediate G protein\u2013coupled receptor\u2013 or growth factor receptor\u2013induced NF-\u03baB activation. However, the in vivo function of Carma3 has remained elusive. Here, by establishing a Con A\u2013induced autoimmune hepatitis model, we show that liver injury is exacerbated in Carma3\u2212\/\u2212 mice. Surprisingly, we find that the Carma3 expression level is higher in liver sinusoidal endothelial cells (LSECs) than in hepatocytes in the liver. In Carma3\u2212\/\u2212 mice, Con A treatment induces more LSEC damage, accompanied by severer coagulation. In vitro we find that Carma3 localizes at mitochondria and Con A treatment can trigger more mitochondrial damage and cell death in Carma3-deficient LSECs. Taken together, our data uncover an unrecognized role of Carma3 in maintaining LSEC integrity, and these results may extend novel strategies to prevent liver injury from toxic insults.<\/jats:p>","DOI":"10.4049\/jimmunol.2101195","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T04:51:18Z","timestamp":1672721478000},"page":"456-464","source":"Crossref","is-referenced-by-count":2,"title":["Carma3 Protects from Liver Injury by Preserving Mitochondrial Integrity in Liver Sinusoidal Endothelial Cells"],"prefix":"10.1093","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0906-1806","authenticated-orcid":false,"given":"Liqing","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Tsinghua University School of Medicine , Beijing,","place":["China"]},{"name":"Tsinghua-Peking Center for Life Sciences , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1045-4917","authenticated-orcid":false,"given":"Zhanqi","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Tsinghua University School of Medicine , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaopeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Tsinghua University School of Medicine , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renlin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Tsinghua University School of Medicine , Beijing,","place":["China"]},{"name":"Tsinghua-Peking Center for Life Sciences , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"Tsinghua Changgung Hospital , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muchun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Tsinghua University School of Medicine , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naixue","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Tsinghua University School of Medicine , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0218-6921","authenticated-orcid":false,"given":"Shulin","family":"Li","sequence":"additional","affiliation":[{"name":"Tsinghua-Peking Center for Life Sciences , Beijing,","place":["China"]},{"name":"Tsinghua University School of Life Sciences , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyi","family":"Gao","sequence":"additional","affiliation":[{"name":"Tsinghua-Peking Center for Life Sciences , Beijing,","place":["China"]},{"name":"Tsinghua University School of Life Sciences , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Tsinghua University School of Medicine , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0956-3654","authenticated-orcid":false,"given":"Xin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Tsinghua University School of Medicine , Beijing,","place":["China"]},{"name":"Tsinghua-Peking Center for Life Sciences , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,1]]},"reference":[{"key":"2025021008225895800_r1","doi-asserted-by":"crossref","first-page":"21405","DOI":"10.1074\/jbc.M102488200","article-title":"Card10 is a novel caspase recruitment domain\/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-\u03baB","volume":"276","author":"Wang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2025021008225895800_r2","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.3389\/fimmu.2018.01887","article-title":"CARMA3 is a critical mediator of G protein-coupled receptor and receptor tyrosine kinase-driven solid tumor pathogenesis","volume":"9","author":"McAuley","year":"2018","journal-title":"Front. Immunol."},{"key":"2025021008225895800_r3","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1073\/pnas.0608388103","article-title":"Bcl10 and Malt1 control lysophosphatidic acid-induced NF-\u03baB activation and cytokine production","volume":"104","author":"Klemm","year":"2007","journal-title":"Proc. Natl. Acad. Sci. 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