{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:40:50Z","timestamp":1784133650789,"version":"3.55.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI125859"],"award-info":[{"award-number":["AI125859"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Dendritic cells (DCs) are professional APCs equipped with MHC-restricted Ags, costimulations, and cytokines that effectively prime and differentiate naive T cells into distinct functional subsets. The immune signals that DCs carry reflect the route of Ag uptake and the innate stimuli they received. In the mucosal tissues, owing to the great variety of foreign Ags and inflammatory cues, DCs are predominantly activated and migratory. In the small intestine, CD4 Th17 cells are abundant and have been shown to be regulated by DCs and macrophages. Using a mouse commensal bacteria experimental model, we identified that the early priming step of commensal-driven Th17 cells is controlled by bona fide Zbtb46-expressing DCs. CCR7-dependent migration of type 2 DCs (DC2s) from the small intestine to the mesenteric lymph nodes (MLNs) is essential for the activation of naive CD4 T cells. The migratory DC2 population in the MLNs is almost exclusively Esam+ cells. Single-cell RNA sequencing highlighted the abundance of costimulatory markers (CD40 and OX40) and chemokines (Ccl22 and Cxcl16) on MLN migratory DCs. Further resolution of MLN migratory DC2s revealed that the Th17-polarizing cytokine IL-6 colocalizes with DC2s expressing CD40, Ccl17, and Ccl22. Thus, early Th17 cell differentiation is initiated by a small subset of migratory DC2s in the gut-draining lymph nodes.<\/jats:p>","DOI":"10.4049\/jimmunol.2200204","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T04:13:23Z","timestamp":1672719203000},"page":"1200-1211","source":"Crossref","is-referenced-by-count":17,"title":["Migrating Type 2 Dendritic Cells Prime Mucosal Th17 Cells Specific to Small Intestinal Commensal Bacteria"],"prefix":"10.1093","volume":"209","author":[{"given":"Soo","family":"Ngoi","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, The Ohio State University , Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina , Charleston, SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Iwanowycz","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina , Charleston, SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina , Charleston, SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina , Charleston, SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina , Charleston, SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Hill","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, The Ohio State University , Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjun","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, The Ohio State University , Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carter","family":"Allen","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, The Ohio State University , Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, The Ohio State University , Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"key":"2025021008304833900_r1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.immuni.2017.02.019","article-title":"Dendritic cells display subset and tissue-specific maturation dynamics over human life","volume":"46","author":"Granot","year":"2017","journal-title":"Immunity"},{"key":"2025021008304833900_r2","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.immuni.2016.08.015","article-title":"Unsupervised high-dimensional analysis aligns dendritic cells across tissues and species","volume":"45","author":"Guilliams","year":"2016","journal-title":"Immunity"},{"key":"2025021008304833900_r3","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.immuni.2009.08.027","article-title":"Selective expression of the chemokine receptor XCR1 on cross-presenting dendritic cells determines cooperation with CD8+ T cells","volume":"31","author":"Dorner","year":"2009","journal-title":"Immunity"},{"key":"2025021008304833900_r4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev-immunol-032713-120204","article-title":"Transcriptional control of dendritic cell development","volume":"34","author":"Murphy","year":"2016","journal-title":"Annu. 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