{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:00:04Z","timestamp":1793826004891,"version":"4.6.1"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Ontario Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chronic infection with human CMV may contribute to poor vaccine efficacy in older adults. We assessed the effects of CMV serostatus on Ab quantity and quality, as well as cellular memory recall responses, after two and three SARS-CoV-2 mRNA vaccine doses, in older adults in assisted living facilities. CMV serostatus did not affect anti-Spike and anti\u2013receptor-binding domain IgG Ab levels, nor neutralization capacity against wild-type or \u03b2 variants of SARS-CoV-2 several months after vaccination. CMV seropositivity altered T cell expression of senescence-associated markers and increased effector memory re-expressing CD45RA T cell numbers, as has been previously reported; however, this did not impact Spike-specific CD4+ T cell memory recall responses. CMV-seropositive individuals did not have a higher incidence of COVID-19, although prior infection influenced humoral immunity. Therefore, CMV seropositivity may alter T cell composition but does not impede the durability of humoral protection or cellular memory responses after SARS-CoV-2 mRNA vaccination in older adults.<\/jats:p>","DOI":"10.4049\/jimmunol.2200369","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T05:02:13Z","timestamp":1672722133000},"page":"1892-1905","source":"Crossref","is-referenced-by-count":25,"title":["Cytomegalovirus Seropositivity in Older Adults Changes the T Cell Repertoire but Does Not Prevent Antibody or Cellular Responses to SARS-CoV-2 Vaccination"],"prefix":"10.1093","volume":"209","author":[{"name":"COVID-in-LTC Investigator Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5434-9158","authenticated-orcid":false,"given":"Jessica A","family":"Breznik","sequence":"additional","affiliation":[{"name":"McMaster Immunology Research Centre, McMaster University , Hamilton, Ontario,","place":["Canada"]},{"name":"Michael G. DeGroote Institute for Infectious Disease Research, McMaster University , Hamilton, Ontario,","place":["Canada"]},{"name":"Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University , Hamilton, Ontario,","place":["Canada"]},{"name":"McMaster Institute for Research on Aging, McMaster University , Hamilton, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Huynh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University , Hamilton, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Zhang","sequence":"additional","affiliation":[{"name":"McMaster Immunology Research Centre, McMaster University , Hamilton, Ontario,","place":["Canada"]},{"name":"Michael G. DeGroote Institute for Infectious Disease Research, McMaster University , Hamilton, Ontario,","place":["Canada"]},{"name":"Department of Biochemistry and Biomedical Sciences, McMaster University , Hamilton, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1977-9339","authenticated-orcid":false,"given":"Lucas","family":"Bilaver","sequence":"additional","affiliation":[{"name":"McMaster Immunology Research Centre, McMaster University , Hamilton, Ontario,","place":["Canada"]},{"name":"Michael G. DeGroote Institute for Infectious Disease Research, McMaster University , Hamilton, Ontario,","place":["Canada"]},{"name":"Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University , Hamilton, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hina","family":"Bhakta","sequence":"additional","affiliation":[{"name":"Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University , Hamilton, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah D","family":"Stacey","sequence":"additional","affiliation":[{"name":"McMaster Immunology Research Centre, McMaster University , Hamilton, Ontario,","place":["Canada"]},{"name":"Michael G. DeGroote Institute for Infectious Disease Research, McMaster University , Hamilton, Ontario,","place":["Canada"]},{"name":"Department of Biochemistry and Biomedical Sciences, McMaster University , Hamilton, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jann C","family":"Ang","sequence":"additional","affiliation":[{"name":"McMaster Immunology Research Centre, McMaster University , Hamilton, Ontario,","place":["Canada"]},{"name":"Michael G. DeGroote Institute for Infectious Disease Research, McMaster University , Hamilton, Ontario,","place":["Canada"]},{"name":"Department of Biochemistry and Biomedical Sciences, McMaster University , Hamilton, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L","family":"Bramson","sequence":"additional","affiliation":[{"name":"McMaster Immunology Research Centre, McMaster University , Hamilton, Ontario,","place":["Canada"]},{"name":"Michael G. DeGroote Institute for Infectious Disease Research, McMaster University , Hamilton, Ontario,","place":["Canada"]},{"name":"Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University , Hamilton, Ontario,","place":["Canada"]},{"name":"Department of Biochemistry and Biomedical Sciences, McMaster University , Hamilton, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5695-4343","authenticated-orcid":false,"given":"Ishac","family":"Nazy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University , Hamilton, Ontario,","place":["Canada"]},{"name":"McMaster Centre for Transfusion Research, McMaster University , Hamilton, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3426-5069","authenticated-orcid":false,"given":"Matthew S","family":"Miller","sequence":"additional","affiliation":[{"name":"McMaster Immunology Research Centre, McMaster University , Hamilton, Ontario,","place":["Canada"]},{"name":"Michael G. DeGroote Institute for Infectious Disease Research, McMaster University , Hamilton, Ontario,","place":["Canada"]},{"name":"Department of Biochemistry and Biomedical Sciences, McMaster University , Hamilton, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5398-0063","authenticated-orcid":false,"given":"Judah","family":"Denburg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University , Hamilton, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9212-5641","authenticated-orcid":false,"given":"Andrew P","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University , Hamilton, Ontario,","place":["Canada"]},{"name":"Department of Health Research Methods, Evidence, and Impact, McMaster University , Hamilton, Ontario,","place":["Canada"]},{"name":"Centre for Integrated Care, St. Joseph\u2019s Health System , Hamilton, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6823-2957","authenticated-orcid":false,"given":"Dawn M E","family":"Bowdish","sequence":"additional","affiliation":[{"name":"McMaster Immunology Research Centre, McMaster University , Hamilton, Ontario,","place":["Canada"]},{"name":"Michael G. DeGroote Institute for Infectious Disease Research, McMaster University , Hamilton, Ontario,","place":["Canada"]},{"name":"Department of Medicine, Michael G. 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