{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:43:24Z","timestamp":1788248604126,"version":"build-2803163510"},"reference-count":196,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100009633","name":"HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HHSN275201300006C"],"award-info":[{"award-number":["HHSN275201300006C"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wayne State University Perinatal Initiative in Maternal, Perinatal and Child Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pregnancy success requires constant dialogue between the mother and developing conceptus. Such crosstalk is facilitated through complex interactions between maternal and fetal cells at distinct tissue sites, collectively termed the \u201cmaternal\u2013fetal interface.\u201d The emergence of single-cell technologies has enabled a deeper understanding of the unique processes taking place at the maternal\u2013fetal interface as well as the discovery of novel pathways and immune and nonimmune cell types. Single-cell approaches have also been applied to decipher the cellular dynamics throughout pregnancy, in parturition, and in obstetrical syndromes such as recurrent spontaneous abortion, preeclampsia, and preterm labor. Furthermore, single-cell technologies have been used during the recent COVID-19 pandemic to evaluate placental viral cell entry and the impact of SARS-CoV-2 infection on maternal and fetal immunity. In this brief review, we summarize the current knowledge of cellular immunobiology in pregnancy and its complications that has been generated through single-cell investigations of the maternal\u2013fetal interface.<\/jats:p>","DOI":"10.4049\/jimmunol.2200433","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T13:40:09Z","timestamp":1666273209000},"page":"1450-1464","source":"Crossref","is-referenced-by-count":41,"title":["Single-Cell Immunobiology of the Maternal\u2013Fetal Interface"],"prefix":"10.1093","volume":"209","author":[{"given":"Derek","family":"Miller","sequence":"first","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services , Detroit, MI"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine , Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3243-1780","authenticated-orcid":false,"given":"Valeria","family":"Garcia-Flores","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services , Detroit, MI"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine , Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4448-5121","authenticated-orcid":false,"given":"Roberto","family":"Romero","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services , Detroit, MI"},{"name":"Department of Obstetrics and Gynecology, University of Michigan , Ann Arbor, MI"},{"name":"Department of Epidemiology and Biostatistics, Michigan State University , East Lansing, MI"},{"name":"Center for Molecular Medicine and Genetics, Wayne State University , Detroit, MI"},{"name":"Detroit Medical Center , Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8160-8581","authenticated-orcid":false,"given":"Jose","family":"Galaz","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services , Detroit, MI"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine , Detroit, MI"},{"name":"Division of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Catolica de Chile , Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1262-2275","authenticated-orcid":false,"given":"Roger","family":"Pique-Regi","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services , Detroit, MI"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine , Detroit, MI"},{"name":"Center for Molecular Medicine and Genetics, Wayne State University , Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3406-5262","authenticated-orcid":false,"given":"Nardhy","family":"Gomez-Lopez","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services , Detroit, MI"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine , Detroit, MI"},{"name":"Department of Biochemistry, Microbiology and Immunology, Wayne State University School of Medicine , Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,15]]},"reference":[{"key":"2025021008345672500_r1","volume-title":"Williams 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