{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T13:16:03Z","timestamp":1776777363595,"version":"3.51.2"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI125623"],"award-info":[{"award-number":["R01AI125623"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI139703"],"award-info":[{"award-number":["R21AI139703"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A growing body of evidence has shown that resident memory T (TRM) cells formed in tissue after mucosal infection or vaccination are crucial for counteracting reinfection by pathogens. However, whether lung TRM cells activated by oral immunization with Yptb1(pYA5199) play a protective role against pneumonic plague remains unclear. In this study, we demonstrated that lung CD4+ and CD8+ TRM cells significantly accumulated in the lungs of orally Yptb1(pYA5199)-vaccinated mice and dramatically expanded with elevated IL-17A, IFN-\u03b3, and\/or TNF-\u03b1 production after pulmonary Yersinia pestis infection and afforded significant protection. Short-term or long-term treatment of immunized mice with FTY720 did not affect lung TRM cell formation and expansion or protection against pneumonic plague. Moreover, the intratracheal transfer of both lung CD4+ and CD8+ TRM cells conferred comprehensive protection against pneumonic plague in naive recipient mice. Lung TRM cell\u2013mediated protection was dramatically abolished by the neutralization of both IFN-\u03b3 and IL-17A. Our findings reveal that lung TRM cells can be activated via oral Yptb1(pYA5199) vaccination, and that IL-17A and IFN-\u03b3 production play an essential role in adaptive immunity against pulmonary Y. pestis infection. This study highlights an important new target for developing an effective pneumonic plague vaccine.<\/jats:p>","DOI":"10.4049\/jimmunol.2200487","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T14:57:28Z","timestamp":1672671448000},"page":"259-270","source":"Crossref","is-referenced-by-count":10,"title":["Lung Resident Memory T Cells Activated by Oral Vaccination Afford Comprehensive Protection against Pneumonic <i>Yersinia pestis<\/i> Infection"],"prefix":"10.1093","volume":"210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5074-3038","authenticated-orcid":false,"given":"Amit K","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbial Disease, Albany Medical College , Albany, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saugata","family":"Majumder","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbial Disease, Albany Medical College , Albany, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2791-5441","authenticated-orcid":false,"given":"Xiuran","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbial Disease, Albany Medical College , Albany, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renjie","family":"Song","sequence":"additional","affiliation":[{"name":"Immunology Core at Wadsworth Center, New York State Department of Health , Albany, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0071-6987","authenticated-orcid":false,"given":"Wei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbial Disease, Albany Medical College , Albany, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"key":"2025021007590766900_r1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.tim.2015.11.008","article-title":"Pneumonic plague: the darker side of Yersinia pestis","volume":"24","author":"Pechous","year":"2016","journal-title":"Trends Microbiol."},{"key":"2025021007590766900_r2","first-page":"411","article-title":"Factors influencing the re-emergence of plague in Madagascar","volume":"4","author":"Alderson","year":"2020","journal-title":"Emerg. 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