{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T14:32:03Z","timestamp":1785335523770,"version":"3.55.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"MRFF","award":["APP1162217"],"award-info":[{"award-number":["APP1162217"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>NKp44 is a human receptor originally found on activated NK cells, group 1 and group 3 innate lymphoid cells that binds dimers of platelet-derived growth factor D (PDGF-DD). NKp44 is also expressed on tissue plasmacytoid dendritic cells (PDCs), but NKp44-PDGF-DD interaction on PDCs remains unstudied. Engagement of NKp44 with PDGF-DD in vitro enhanced PDC secretion of IFN-\u03b1, TNF, and IL-6 in response to the TLR9 ligand CpG-ODN, but not TLR7\/8 ligands. In tissues, PDCs were found in close contact with PDGF-DD\u2013expressing cells in the high endothelial venules and epithelium of tonsils, melanomas, and skin lesions infected with Molluscum contagiosum. Recombinant PDGF-DD enhanced the serum IFN-\u03b1 response to systemic HSV-1 infection in a humanized mouse model. We conclude that NKp44 integrates with TLR9 signaling to enhance PDC cytokine production. These findings may have bearings for immune responses to TLR9-based adjuvants, therapy for tumors expressing PDGF-DD, and infections with DNA viruses that induce PDGF-DD expression to enhance viral spread.<\/jats:p>","DOI":"10.4049\/jimmunol.2200496","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T18:16:51Z","timestamp":1703096211000},"page":"369-374","source":"Crossref","is-referenced-by-count":10,"title":["Cutting Edge: PDGF-DD Binding to NKp44 Costimulates TLR9 Signaling and Proinflammatory Cytokine Secretion in Human Plasmacytoid Dendritic Cells"],"prefix":"10.1093","volume":"212","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5833-0537","authenticated-orcid":false,"given":"Alexander David","family":"Barrow","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO"},{"name":"Department of Microbiology and Immunology, The University of Melbourne and The Peter Doherty Institute for Infection and Immunity , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1230-1313","authenticated-orcid":false,"given":"Marina","family":"Cella","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8672-8339","authenticated-orcid":false,"given":"Melissa Anne","family":"Edeling","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO"},{"name":"Department of Microbiology and Immunology, The University of Melbourne and The Peter Doherty Institute for Infection and Immunity , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3484-6333","authenticated-orcid":false,"given":"Md. Abdullah-Al-Kamran","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, The University of Melbourne and The Peter Doherty Institute for Infection and Immunity , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Cervantes-Barragan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO"},{"name":"Department of Microbiology and Immunology, Emory University, School of Medicine , Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Bugatti","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine, Section of Pathology, School of Medicine, University of Brescia , Brescia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schmedt","sequence":"additional","affiliation":[{"name":"Function Oncology Inc. , San Diego, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2291-2997","authenticated-orcid":false,"given":"William","family":"Vermi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO"},{"name":"Department of Molecular and Translational Medicine, Section of Pathology, School of Medicine, University of Brescia , Brescia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Colonna","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"key":"2025020405433411400_r1","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1182\/blood-2004-12-4802","article-title":"Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44","volume":"106","author":"Fuchs","year":"2005","journal-title":"Blood"},{"key":"2025020405433411400_r2","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nature07537","article-title":"A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity","volume":"457","author":"Cella","year":"2009","journal-title":"Nature"},{"key":"2025020405433411400_r3","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1084\/jem.189.5.787","article-title":"NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily","volume":"189","author":"Cantoni","year":"1999","journal-title":"J. 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