{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:00:35Z","timestamp":1791820835778,"version":"4.3.4"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK107905"],"award-info":[{"award-number":["DK107905"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["AR007534"],"award-info":[{"award-number":["AR007534"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["AI007405"],"award-info":[{"award-number":["AI007405"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR079369"],"award-info":[{"award-number":["AR079369"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Intraepithelial lymphocytes (IELs) are T cells important for the maintenance of barrier integrity in the intestine. Colon IELs are significantly reduced in both MyD88-deficient mice and those lacking an intact microbiota, suggesting that MyD88-mediated detection of bacterial products is important for the recruitment and\/or retention of these cells. Here, using conditionally deficient MyD88 mice, we show that myeloid cells are the key mediators of TCR\u03b1\u03b2+ IEL recruitment to the colon. Upon exposure to luminal bacteria, myeloid cells produce sphingosine-1-phosphate (S1P) in a MyD88-dependent fashion. TCR\u03b1\u03b2+ IEL recruitment may be blocked using the S1P receptor antagonist FTY720, confirming the importance of S1P in the recruitment of TCR\u03b1\u03b2+ IELs to the colon epithelium. Finally, using the TNF\u0394ARE\/+ model of Crohn\u2019s-like bowel inflammation, we show that disruption of colon IEL recruitment through myeloid-specific MyD88 deficiency results in reduced pathology. Our results illustrate one mechanism for recruitment of a subset of IELs to the colon.<\/jats:p>","DOI":"10.4049\/jimmunol.2200556","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T13:55:32Z","timestamp":1712152532000},"page":"1843-1854","source":"Crossref","is-referenced-by-count":1,"title":["Myeloid Cells and Sphingosine-1-Phosphate Are Required for TCR\u03b1\u03b2 Intraepithelial Lymphocyte Recruitment to the Colon Epithelium"],"prefix":"10.1093","volume":"212","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1512-882X","authenticated-orcid":false,"given":"Sarah Mann","family":"Danielson","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus , Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2394-7833","authenticated-orcid":false,"given":"Adam R","family":"Lefferts","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus , Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Norman","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus , Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie H","family":"Regner","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus , Aurora, CO"},{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, University of Colorado Anschutz Medical Campus , Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna M","family":"Schulz","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus , Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7466-9255","authenticated-orcid":false,"given":"Danielle","family":"Sansone-Poe","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus , Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0417-1400","authenticated-orcid":false,"given":"David J","family":"Orlicky","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Colorado School of Medicine , Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6900-4195","authenticated-orcid":false,"given":"Kristine A","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus , Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"2025020405502547900_r1","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/ni1101-997","article-title":"Intraepithelial lymphocytes: exploring the Third Way in immunology","volume":"2","author":"Hayday","year":"2001","journal-title":"Nat. Immunol."},{"key":"2025020405502547900_r2","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1126\/science.aaf3892","article-title":"Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation","volume":"352","author":"Sujino","year":"2016","journal-title":"Science"},{"key":"2025020405502547900_r3","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.it.2017.11.003","article-title":"Intestinal intraepithelial lymphocytes: sentinels of the mucosal barrier","volume":"39","author":"Olivares-Villagomez","year":"2018","journal-title":"Trends Immunol."},{"key":"2025020405502547900_r4","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/s41385-018-0016-5","article-title":"Human intraepithelial lymphocytes","volume":"11","author":"Mayassi","year":"2018","journal-title":"Mucosal Immunol."},{"key":"2025020405502547900_r5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nri3007","article-title":"The light and dark sides of intestinal intraepithelial lymphocytes","volume":"11","author":"Cheroutre","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"2025020405502547900_r6","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2017.08.046","article-title":"Intestinal epithelial and intraepithelial T cell crosstalk mediates a dynamic response to infection","volume":"171","author":"Hoytema van Konijnenburg","year":"2017","journal-title":"Cell"},{"key":"2025020405502547900_r7","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/mi.2017.55","article-title":"Bacteroidales recruit IL-6-producing intraepithelial lymphocytes in the colon to promote barrier integrity","volume":"11","author":"Kuhn","year":"2018","journal-title":"Mucosal Immunol."},{"key":"2025020405502547900_r8","doi-asserted-by":"crossref","first-page":"e114195","DOI":"10.1371\/journal.pone.0114195","article-title":"IL-6 stimulates intestinal epithelial proliferation and repair after injury","volume":"9","author":"Kuhn","year":"2014","journal-title":"PLoS One"},{"key":"2025020405502547900_r9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s13075-018-1639-3","article-title":"Functional intraepithelial lymphocyte changes in inflammatory bowel disease and spondyloarthritis have disease specific correlations with intestinal microbiota","volume":"20","author":"Regner","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"2025020405502547900_r10","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S1074-7613(00)80038-2","article-title":"Impaired on\/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies","volume":"10","author":"Kontoyiannis","year":"1999","journal-title":"Immunity"},{"key":"2025020405502547900_r11","doi-asserted-by":"crossref","first-page":"15281","DOI":"10.1038\/s41598-017-13667-8","article-title":"Structural and functional insight of sphingosine 1-phosphate-mediated pathogenic metabolic reprogramming in sickle cell disease","volume":"7","author":"Sun","year":"2017","journal-title":"Sci. Rep."},{"key":"2025020405502547900_r12","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/rcm.7834","article-title":"A three-minute method for high-throughput quantitative metabolomics and quantitative tracing experiments of central carbon and nitrogen pathways","volume":"31","author":"Nemkov","year":"2017","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"2025020405502547900_r13","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1053\/gast.2001.29568","article-title":"Antibody blockade of ICAM-1 and VCAM-1 ameliorates inflammation in the SAMP-1\/Yit adoptive transfer model of Crohn\u2019s disease in mice","volume":"121","author":"Burns","year":"2001","journal-title":"Gastroenterology"},{"key":"2025020405502547900_r14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1046\/j.1365-2249.1998.00728.x","article-title":"Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines","volume":"114","author":"Dieleman","year":"1998","journal-title":"Clin. Exp. Immunol."},{"key":"2025020405502547900_r15","doi-asserted-by":"crossref","first-page":"12070","DOI":"10.1073\/pnas.92.26.12070","article-title":"T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination","volume":"92","author":"Hennet","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2025020405502547900_r16","doi-asserted-by":"crossref","first-page":"33275","DOI":"10.1074\/jbc.M204935200","article-title":"Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine","volume":"277","author":"Madison","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2025020405502547900_r17","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1008942828960","article-title":"Conditional gene targeting in macrophages and granulocytes using LysMcre mice","volume":"8","author":"Clausen","year":"1999","journal-title":"Transgenic Res."},{"key":"2025020405502547900_r18","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/mi.2012.23","article-title":"Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides","volume":"5","author":"Frantz","year":"2012","journal-title":"Mucosal Immunol."},{"key":"2025020405502547900_r19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1471-213X-9-49","article-title":"Use of KikGR a photoconvertible green-to-red fluorescent protein for cell labeling and lineage analysis in ES cells and mouse embryos","volume":"9","author":"Nowotschin","year":"2009","journal-title":"BMC Dev. Biol."},{"key":"2025020405502547900_r20","doi-asserted-by":"crossref","first-page":"932393","DOI":"10.3389\/fimmu.2022.932393","article-title":"Cytokine competent gut-joint migratory T cells contribute to inflammation in the joint","volume":"13","author":"Lefferts","year":"2022","journal-title":"Front. Immunol."},{"key":"2025020405502547900_r21","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.immuni.2015.05.018","article-title":"GM-CSF mouse bone marrow cultures comprise a heterogeneous population of CD11c+MHCII+ macrophages and dendritic cells","volume":"42","author":"Helft","year":"2015","journal-title":"Immunity"},{"key":"2025020405502547900_r22","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.str.2013.02.025","article-title":"Molecular basis of sphingosine kinase 1 substrate recognition and catalysis","volume":"21","author":"Wang","year":"2013","journal-title":"Structure"},{"key":"2025020405502547900_r23","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.bbalip.2009.02.011","article-title":"Export and functions of sphingosine-1-phosphate","volume":"1791","author":"Kim","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"2025020405502547900_r24","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1111\/j.1471-4159.2007.04958.x","article-title":"Critical role of ABCA1 transporter in sphingosine 1-phosphate release from astrocytes","volume":"103","author":"Sato","year":"2007","journal-title":"J. Neurochem."},{"key":"2025020405502547900_r25","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1194\/jlr.S091959","article-title":"New insights into functions of the sphingosine-1-phosphate transporter SPNS2","volume":"60","author":"Spiegel","year":"2019","journal-title":"J. Lipid Res."},{"key":"2025020405502547900_r26","doi-asserted-by":"crossref","first-page":"7382","DOI":"10.3892\/mmr.2017.7511","article-title":"Microarray and bioinformatics analyses of gene expression profiles in BALB\/c murine macrophage polarization","volume":"16","author":"Jiang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"2025020405502547900_r27","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.4049\/jimmunol.178.6.3437","article-title":"Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3","volume":"178","author":"Maeda","year":"2007","journal-title":"J. Immunol."},{"key":"2025020405502547900_r28","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.4049\/jimmunol.170.7.3662","article-title":"Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated CD4+ T cells","volume":"170","author":"Xie","year":"2003","journal-title":"J. Immunol."},{"key":"2025020405502547900_r29","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.intimp.2010.10.005","article-title":"Fingolimod (FTY720), sphingosine 1-phosphate receptor modulator, shows superior efficacy as compared with interferon-\u03b2 in mouse experimental autoimmune encephalomyelitis","volume":"11","author":"Chiba","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"2025020405502547900_r30","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1136\/gutjnl-2015-309333","article-title":"Dysbiotic gut microbiota causes transmissible Crohn\u2019s disease-like ileitis independent of failure in antimicrobial defence","volume":"65","author":"Schaubeck","year":"2016","journal-title":"Gut"},{"key":"2025020405502547900_r31","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/ncomms2113","article-title":"MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice","volume":"3","author":"Hoshi","year":"2012","journal-title":"Nat. Commun."},{"key":"2025020405502547900_r32","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.4049\/jimmunol.180.4.2573","article-title":"A CD8+\/CD103high T cell subset regulates TNF-mediated chronic murine ileitis","volume":"180","author":"Ho","year":"2008","journal-title":"J. Immunol."},{"key":"2025020405502547900_r33","doi-asserted-by":"crossref","first-page":"e00007-17","DOI":"10.1128\/MMBR.00007-17","article-title":"Vaccination against Salmonella infection: the mucosal way","volume":"81","author":"Gayet","year":"2017","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"2025020405502547900_r34","doi-asserted-by":"crossref","first-page":"97","DOI":"10.12703\/P6-97","article-title":"MyD88: a central player in innate immune signaling","volume":"6","author":"Deguine","year":"2014","journal-title":"F1000Prime Rep."},{"key":"2025020405502547900_r35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4049\/jimmunol.1203103","article-title":"MyD88: a critical adaptor protein in innate immunity signal transduction","volume":"190","author":"Warner","year":"2013","journal-title":"J. Immunol."},{"key":"2025020405502547900_r36","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"2025020405502547900_r37","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1038\/emm.2013.97","article-title":"Recognition of lipopolysaccharide pattern by TLR4 complexes","volume":"45","author":"Park","year":"2013","journal-title":"Exp. Mol. Med."},{"key":"2025020405502547900_r38","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nri2301","article-title":"TLR4 signalling","volume":"8","author":"Bell","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"2025020405502547900_r39","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1038\/s41590-019-0513-z","article-title":"Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling","volume":"20","author":"Liu","year":"2019","journal-title":"Nat. Immunol."},{"key":"2025020405502547900_r40","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrc2875","article-title":"Sphingosine 1-phosphate and cancer","volume":"10","author":"Pyne","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"2025020405502547900_r41","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.tips.2010.11.002","article-title":"Sphingosine-1-phosphate and immune regulation: trafficking and beyond","volume":"32","author":"Chi","year":"2011","journal-title":"Trends Pharmacol. Sci."},{"key":"2025020405502547900_r42","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/intimm\/dxz037","article-title":"Sphingosine 1-phosphate and inflammation","volume":"31","author":"Obinata","year":"2019","journal-title":"Int. Immunol."},{"key":"2025020405502547900_r43","first-page":"8606878","article-title":"Sphingosine-1-phosphate signaling in immune cells and inflammation: roles and therapeutic potential","volume":"2016","author":"Aoki","year":"2016","journal-title":"Mediators Inflamm."},{"key":"2025020405502547900_r44","doi-asserted-by":"crossref","first-page":"651727","DOI":"10.1155\/2014\/651727","article-title":"Sphingosine-1-phosphate transporters as targets for cancer therapy","volume":"2014","author":"Nagahashi","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"2025020405502547900_r45","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.3389\/fimmu.2019.01706","article-title":"Sphingosine-1-phosphate and macrophage biology-how the sphinx tames the big eater","volume":"10","author":"Weigert","year":"2019","journal-title":"Front. Immunol."},{"key":"2025020405502547900_r46","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000362982","article-title":"Sphingosine-1-phosphate modulates dendritic cell function: focus on non-migratory effects in vitro and in vivo","volume":"34","author":"Arlt","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"key":"2025020405502547900_r47","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/mi.2016.35","article-title":"Sphingosine-1-phosphate receptor-1 (S1P(1)) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease","volume":"10","author":"Karuppuchamy","year":"2017","journal-title":"Mucosal Immunol."},{"key":"2025020405502547900_r48","article-title":"U.S. Food and Drug Administration approves Bristol Myers Squibb\u2019s Zeposia (ozanimod), an oral treatment for adults with moderately to severely active ulcerative colitis","author":"Bristol Myers Squibb","year":"2021"},{"key":"2025020405502547900_r49","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S2468-1253(20)30188-6","article-title":"Ozanimod induction therapy for patients with moderate to severe Crohn\u2019s disease: a single-arm, phase 2, prospective observer-blinded endpoint study","volume":"5","author":"Feagan","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"2025020405502547900_r50","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1172\/JCI118861","article-title":"Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4+ TH1-like responses","volume":"98","author":"Berg","year":"1996","journal-title":"J. Clin. Invest."},{"key":"2025020405502547900_r51","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.immuni.2020.09.003","article-title":"T cell receptor is required for differentiation, but not maintenance, of intestinal CD4+ intraepithelial lymphocytes","volume":"53","author":"Bilate","year":"2020","journal-title":"Immunity"},{"key":"2025020405502547900_r52","doi-asserted-by":"crossref","first-page":"e70055","DOI":"10.7554\/eLife.70055","article-title":"Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes","volume":"10","author":"Brenes","year":"2021","journal-title":"Elife"},{"key":"2025020405502547900_r53","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1084\/jem.20162014","article-title":"Tissue adaptation: implications for gut immunity and tolerance","volume":"214","author":"Faria","year":"2017","journal-title":"J. Exp. Med."},{"key":"2025020405502547900_r54","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s40495-017-0105-2","article-title":"Sentinels at the frontline: the role of intraepithelial lymphocytes in inflammatory bowel disease","volume":"3","author":"Hu","year":"2017","journal-title":"Curr. Pharmacol. Rep."},{"key":"2025020405502547900_r55","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/s41577-018-0013-7","article-title":"Diverse developmental pathways of intestinal intraepithelial lymphocytes","volume":"18","author":"McDonald","year":"2018","journal-title":"Nat. Rev. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/212\/11\/1843\/61476356\/ji2200556.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/212\/11\/1843\/61476356\/ji2200556.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T05:53:27Z","timestamp":1738648407000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/212\/11\/1843\/7926089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,3]]},"references-count":55,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,6,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2200556","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,6]]},"published":{"date-parts":[[2024,4,3]]}}}