{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:52:17Z","timestamp":1777654337817,"version":"3.51.4"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI105265"],"award-info":[{"award-number":["R01AI105265"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI110613"],"award-info":[{"award-number":["R21AI110613"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>CD8+ T lymphocytes infiltrate the brain during congenital CMV infection and promote viral clearance. However, the mechanisms by which CD8+ T cells are recruited to the brain remain unclear. Using a mouse model of congenital CMV, we found a gut-homing chemokine receptor (CCR9) was preferentially expressed in CD8+ T cells localized in the brain postinfection. In the absence of CCR9 or CCL25 (CCR9\u2019s ligand) expression, CD8+ T cells failed to migrate to key sites of infection in the brain and protect the host from severe forms of disease. Interestingly, we found that expression of CCR9 on CD8+ T cells was also responsible for spatial temporal positioning of T cells in the brain. Collectively, our data demonstrate that the CMV-infected brain uses a similar mechanism for CD8+ T cell homing as the small intestine.<\/jats:p>","DOI":"10.4049\/jimmunol.2200578","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T05:00:33Z","timestamp":1672722033000},"page":"2281-2286","source":"Crossref","is-referenced-by-count":5,"title":["Cutting Edge: CCR9 Promotes CD8+ T Cell Recruitment to the Brain during Congenital Cytomegalovirus Infection"],"prefix":"10.1093","volume":"209","author":[{"given":"Zachary T","family":"Hilt","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1988-7196","authenticated-orcid":false,"given":"Wisler","family":"Charles","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0519-6319","authenticated-orcid":false,"given":"Katarina E","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5846-7269","authenticated-orcid":false,"given":"Cybelle","family":"Tabilas","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Steinhilber","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3445-7570","authenticated-orcid":false,"given":"Samantha P","family":"Wesnak","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7495-7660","authenticated-orcid":false,"given":"Norah L","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7800-9596","authenticated-orcid":false,"given":"Chris B","family":"Schaffer","sequence":"additional","affiliation":[{"name":"Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian D","family":"Rudd","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"2025021008450046900_r1","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.3390\/v13061078","article-title":"Cytomegalovirus infection and inflammation in developing brain","volume":"13","author":"Krstanovi\u0107","year":"2021","journal-title":"Viruses"},{"key":"2025021008450046900_r2","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1001\/archopht.124.5.743","article-title":"Visual impairment and deafness in young children: consider the diagnosis of congenital infection with cytomegalovirus, even years after birth","volume":"124","author":"Andriesse","year":"2006","journal-title":"Arch. 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