{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:02:33Z","timestamp":1783576953738,"version":"3.55.0"},"reference-count":128,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["RSG-20-050-01"],"award-info":[{"award-number":["RSG-20-050-01"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","award":["https:\/\/www.lls.org\/award-recipient\/jaehyuk-choi"],"award-info":[{"award-number":["https:\/\/www.lls.org\/award-recipient\/jaehyuk-choi"]}],"id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mature T cell lymphomas are heterogeneous neoplasms that are aggressive and resistant to treatment. Many of these cancers retain immunological properties of their cell of origin. They express cytokines, cytotoxic enzymes, and cell surface ligands normally induced by TCR signaling in untransformed T cells. Until recently, their molecular mechanisms were unclear. Recently, high-dimensional studies have transformed our understanding of their cellular and genetic characteristics. Somatic mutations in the TCR signaling pathway drive lymphomagenesis by disrupting autoinhibitory domains, increasing affinity to ligands, and\/or inducing TCR-independent signaling. Collectively, most of these mutations augment signaling pathways downstream of the TCR. Emerging data suggest that these mutations not only drive proliferation but also determine lymphoma immunophenotypes. For example, RHOA mutations are sufficient to induce disease-relevant CD4+ T follicular helper cell phenotypes. In this review, we describe how mutations in the TCR signaling pathway elucidate lymphoma pathophysiology but also provide insights into broader T cell biology.<\/jats:p>","DOI":"10.4049\/jimmunol.2200682","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T21:08:04Z","timestamp":1699304884000},"page":"1450-1458","source":"Crossref","is-referenced-by-count":6,"title":["TCR Pathway Mutations in Mature T Cell Lymphomas"],"prefix":"10.1093","volume":"211","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3148-8833","authenticated-orcid":false,"given":"Yue","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Northwestern University Feinberg School of Medicine , Chicago, IL"},{"name":"Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine , Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2478-3156","authenticated-orcid":false,"given":"Kathleen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwestern University Feinberg School of Medicine , Chicago, IL"},{"name":"Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine , Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2379-2226","authenticated-orcid":false,"given":"Jaehyuk","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Northwestern University Feinberg School of Medicine , Chicago, IL"},{"name":"Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine , Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"2025020406180047300_r1","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1182\/blood-2017-11-764357","article-title":"Novel insights into the pathogenesis of T-cell lymphomas","volume":"131","author":"Van Arnam","year":"2018","journal-title":"Blood"},{"key":"2025020406180047300_r2","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","article-title":"The 2016 revision of the World Health Organization classification of lymphoid neoplasms","volume":"127","author":"Swerdlow","year":"2016","journal-title":"Blood"},{"key":"2025020406180047300_r3","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1182\/blood-2014-02-555763","article-title":"Cellular origin of T-cell lymphomas","volume":"123","author":"de Leval","year":"2014","journal-title":"Blood"},{"key":"2025020406180047300_r4","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1182\/blood-2013-11-536359","article-title":"Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma","volume":"123","author":"Iqbal","year":"2014","journal-title":"Blood"},{"key":"2025020406180047300_r5","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1182\/blood-2006-10-055145","article-title":"The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells","volume":"109","author":"de Leval","year":"2007","journal-title":"Blood"},{"key":"2025020406180047300_r6","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1038\/s41375-018-0045-9","article-title":"The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17\/ILC3 skewing of anaplastic large cell lymphoma","volume":"32","author":"Schleussner","year":"2018","journal-title":"Leukemia"},{"key":"2025020406180047300_r7","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1038\/sj.leu.2403965","article-title":"FOXP3, a selective marker for a subset of adult T-cell leukaemia\/lymphoma","volume":"19","author":"Roncador","year":"2005","journal-title":"Leukemia"},{"key":"2025020406180047300_r8","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1182\/blood.2019000779","article-title":"Reproducing the molecular subclassification of peripheral T-cell lymphoma-NOS by immunohistochemistry","volume":"134","author":"Amador","year":"2019","journal-title":"Blood"},{"key":"2025020406180047300_r9","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/cyto.b.21738","article-title":"Na\u00efve\/memory T-cell phenotypes in leukemic cutaneous T-cell lymphoma: Putative cell of origin overlaps disease classification","volume":"96","author":"Horna","year":"2019","journal-title":"Cytometry B Clin. 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