{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:13:07Z","timestamp":1788408787135,"version":"build-2803163510"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100015691","name":"HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI04905"],"award-info":[{"award-number":["R01AI04905"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["K22AI153671"],"award-info":[{"award-number":["K22AI153671"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"HHS | NIH | NIGMS | MTINBRE","doi-asserted-by":"publisher","award":["P20GM103474"],"award-info":[{"award-number":["P20GM103474"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005834","name":"Francis Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005834","name":"American Association of Immunologists Careers in Immunology Fellowship","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000937","name":"M.J. Murdock Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000937","name":"MSU Agriculture Experiment Station","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000937","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The increased incidence of invasive pulmonary aspergillosis, caused by Aspergillus fumigatus, occurring in patients infected with severe influenza or SARS-CoV-2, suggests that antiviral immune responses create an environment permissive to fungal infection. Our recent evidence suggests that absence of the type I IFN receptor 2 subunit (IFNAR2) of the heterodimeric IFNAR1\/2 receptor is allowing for this permissive immune environment of the lung through regulation of damage responses. Because damage is associated with poor outcome to invasive pulmonary aspergillosis, this suggested that IFNAR2 may be involved in A. fumigatus susceptibility. In this study, we determined that absence of IFNAR2 resulted in increased inflammation, morbidity, and damage in the lungs in response to A. fumigatus challenge, whereas absence of IFNAR1 did not. Although the Ifnar2\u2212\/\u2212 mice had increased morbidity, we found that the Ifnar2\u2212\/\u2212 mice cleared more conidia compared with both wild-type and Ifnar1\u2212\/\u2212 mice. However, this early clearance did not prevent invasive disease from developing in the Ifnar2\u2212\/\u2212 mice as infection progressed. Importantly, by altering the inflamed environment of the Ifnar2\u2212\/\u2212 mice early during A. fumigatus infection, by neutralizing TNF-\u03b1, we were able to reduce the morbidity and fungal clearance in these mice back to wild-type levels. Together, our results establish a distinct role for IFNAR2 in regulating host damage responses to A. fumigatus and contributing to an A. fumigatus\u2013permissive environment through regulation of inflammation. Specifically, our data reveal a role for IFNAR2 in regulating TNF-\u03b1\u2013mediated damage and morbidity during A. fumigatus infection.<\/jats:p>","DOI":"10.4049\/jimmunol.2200686","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T12:54:37Z","timestamp":1725022477000},"page":"1202-1211","source":"Crossref","is-referenced-by-count":2,"title":["IFN Receptor 2 Regulates TNF-\u03b1\u2013Mediated Damaging Inflammation during <i>Aspergillus<\/i> Pulmonary Infection"],"prefix":"10.1093","volume":"213","author":[{"given":"Agnieszka","family":"Rynda-Apple","sequence":"first","affiliation":[{"name":"Department of Microbiology and Cell Biology, Montana State University , Bozeman, MT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7738-3580","authenticated-orcid":false,"given":"Jazmin","family":"Reyes Servin","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California , Merced, Merced, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7587-702X","authenticated-orcid":false,"given":"Julianna","family":"Lenz","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California , Merced, Merced, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9675-7945","authenticated-orcid":false,"given":"Julia","family":"Roemer","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Cell Biology, Montana State University , Bozeman, MT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn E","family":"Benson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Cell Biology, Montana State University , Bozeman, MT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4009-4617","authenticated-orcid":false,"given":"Monica N","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Cell Biology, Montana State University , Bozeman, MT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3631-2594","authenticated-orcid":false,"given":"Kelly M","family":"Shepardson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Cell Biology, Montana State University , Bozeman, MT"},{"name":"Department of Molecular and Cell Biology, University of California , Merced, Merced, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"2025020609274580800_r1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/jof3040057","article-title":"Global and multi-national prevalence of fungal diseases\u2014estimate precision","volume":"3","author":"Bongomin","year":"2017","journal-title":"J. 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