{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:33:30Z","timestamp":1791776010646,"version":"4.3.4"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Cain Foundation for Infectious Disease Research"},{"name":"Department of Pulmonary Immunology, UT Health at Tyler"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tissue-resident immune cells play important roles in local tissue homeostasis and infection control. There is no information on the functional role of lung-resident CD3\u2212NK1.1+CD69+CD103+ cells in intranasal Bacillus Calmette\u2013Gu\u00e9rin (BCG)\u2013vaccinated and\/or Mycobacterium tuberculosis (Mtb)\u2013infected mice. Therefore, we phenotypically and functionally characterized these cells in mice vaccinated intranasally with BCG. We found that intranasal BCG vaccination increased CD3\u2212NK1.1+ cells with a tissue-resident phenotype (CD69+CD103+) in the lungs during the first 7 d after BCG vaccination. Three months post-BCG vaccination, Mtb infection induced the expansion of CD3\u2212NK1.1+CD69+CD103+ (lung-resident) cells in the lung. Adoptive transfer of lung-resident CD3\u2212NK1.1+CD69+CD103+ cells from the lungs of BCG-vaccinated mice to Mtb-infected naive mice resulted in a lower bacterial burden and reduced inflammation in the lungs. Our findings demonstrated that intranasal BCG vaccination induces the expansion of CD3\u2212NK1.1+CD69+CD103+ (lung-resident) cells to provide protection against Mtb infection.<\/jats:p>","DOI":"10.4049\/jimmunol.2200728","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T14:05:57Z","timestamp":1721052357000},"page":"669-677","source":"Crossref","is-referenced-by-count":3,"title":["Lung-resident CD3\u2212NK1.1+CD69+CD103+ Cells Play an Important Role in Bacillus Calmette\u2013Gu\u00e9rin Vaccine\u2013Induced Protective Immunity against <i>Mycobacterium tuberculosis<\/i> Infection"],"prefix":"10.1093","volume":"213","author":[{"given":"Olamipejo","family":"Durojaye","sequence":"first","affiliation":[{"name":"Center for Biomedical Research, The University of Texas Health Science Center at Tyler , Tyler, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinav","family":"Vankayalapati","sequence":"additional","affiliation":[{"name":"Center for Biomedical Research, The University of Texas Health Science Center at Tyler , Tyler, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padmaja","family":"Paidipally","sequence":"additional","affiliation":[{"name":"Center for Biomedical Research, The University of Texas Health Science Center at Tyler , Tyler, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6359-653X","authenticated-orcid":false,"given":"Tanmoy","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Center for Biomedical Research, The University of Texas Health Science Center at Tyler , Tyler, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramakrishna","family":"Vankayalapati","sequence":"additional","affiliation":[{"name":"Center for Biomedical Research, The University of Texas Health Science Center at Tyler , Tyler, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh Kumar","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"Center for Biomedical Research, The University of Texas Health Science Center at Tyler , Tyler, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"key":"2025012305145994800_r1","volume-title":"Global tuberculosis report 2023","author":"World Health Organization","year":"2023"},{"key":"2025012305145994800_r2","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3389\/fimmu.2020.00226","article-title":"Thinking outside the box: innate- and B cell-memory responses as novel protective mechanisms against tuberculosis","volume":"11","author":"Chore\u00f1o-Parra","year":"2020","journal-title":"Front. 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