{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T04:12:17Z","timestamp":1773115937804,"version":"3.50.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["19H03699"],"award-info":[{"award-number":["19H03699"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["22H02892"],"award-info":[{"award-number":["22H02892"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["22K19437"],"award-info":[{"award-number":["22K19437"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["19K07626"],"award-info":[{"award-number":["19K07626"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["22K07120"],"award-info":[{"award-number":["22K07120"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Regulatory T cells (Tregs) are produced in the thymus to establish self-tolerance, and agonistic stimuli by self-Ags play a pivotal role in this process. Although two types of APCs, medullary thymic epithelial cells (mTECs) and dendritic cells (DCs), are responsible for presenting self-Ags together with costimulatory\/cytokine signals, the distinct role of each APC in producing Tregs remains enigmatic. We have approached this issue by depleting the mTECs and DCs using mice expressing diphtheria toxin receptors driven by Aire and CD11c promoters, respectively. Depletion of mTECs showed an effect on Treg production quantitatively and qualitatively more profound than that of DCs followed by the development of distinct organ-specific autoimmune lesions in the hosts. Because self-Ags produced by mTECs are transferable to DCs through a process known as Ag transfer, we monitored the process of Ag transfer using mice expressing GFP from TECs. Although GFP expressed from total TECs was effectively transferred to DCs, GFP expressed from cortical TECs was not, suggesting that mTECs are the predominant source of self-Ags. We also found that GFP expressed not only from mature mTECs but also from immature mTECs was transferred to DCs, suggesting that a broad spectrum of molecules were subjected to Ag transfer during mTEC development. Interestingly, the numbers of recirculating non-Tregs producing IL-2, an important source for Treg expansion in the thymus, were reduced only in the mTEC-depleted mice. These results suggested the cooperative but distinct role of mTECs and DCs in the production of Tregs to avoid autoimmunity.<\/jats:p>","DOI":"10.4049\/jimmunol.2200780","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T13:08:10Z","timestamp":1681736890000},"page":"1653-1666","source":"Crossref","is-referenced-by-count":9,"title":["Cooperative but Distinct Role of Medullary Thymic Epithelial Cells and Dendritic Cells in the Production of Regulatory T Cells in the Thymus"],"prefix":"10.1093","volume":"210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8544-939X","authenticated-orcid":false,"given":"Junko","family":"Morimoto","sequence":"first","affiliation":[{"name":"Division of Molecular Immunology, Institute for Enzyme Research, Tokushima University , Tokushima,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1955-6821","authenticated-orcid":false,"given":"Minoru","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology, Institute for Enzyme Research, Tokushima University , Tokushima,","place":["Japan"]},{"name":"Department of Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences , Tokushima,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Oya","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences , Tokushima,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0670-9868","authenticated-orcid":false,"given":"Koichi","family":"Tsuneyama","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Tokushima University Graduate School of Biomedical Sciences , Tokushima,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3844-8110","authenticated-orcid":false,"given":"Mitsuru","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology, Institute for Enzyme Research, Tokushima University , Tokushima,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"2025021008063717400_r1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/ni.3731","article-title":"The multiple pathways to autoimmunity","volume":"18","author":"Theofilopoulos","year":"2017","journal-title":"Nat. Immunol."},{"key":"2025021008063717400_r2","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1056\/NEJMra1911109","article-title":"Tolerance in the age of immunotherapy","volume":"383","author":"Bluestone","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"2025021008063717400_r3","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1146\/annurev.immunol.23.021704.115601","article-title":"A central role for central tolerance","volume":"24","author":"Kyewski","year":"2006","journal-title":"Annu. Rev. Immunol."},{"key":"2025021008063717400_r4","doi-asserted-by":"crossref","first-page":"926625","DOI":"10.3389\/fimmu.2022.926625","article-title":"Mechanisms of direct and indirect presentation of self-antigens in the thymus","volume":"13","author":"B\u0159ezina","year":"2022","journal-title":"Front. Immunol."},{"key":"2025021008063717400_r5","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1146\/annurev.immunol.25.022106.141532","article-title":"Aire","volume":"27","author":"Mathis","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"2025021008063717400_r6","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1126\/science.1075958","article-title":"Projection of an immunological self shadow within the thymus by the Aire protein","volume":"298","author":"Anderson","year":"2002","journal-title":"Science"},{"key":"2025021008063717400_r7","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-immunol-042718-041717","article-title":"Regulatory T cells and human disease","volume":"38","author":"Sakaguchi","year":"2020","journal-title":"Annu. Rev. Immunol."},{"key":"2025021008063717400_r8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cmet.2019.09.010","article-title":"Roles of regulatory T cells in tissue pathophysiology and metabolism","volume":"31","author":"Campbell","year":"2020","journal-title":"Cell Metab."},{"key":"2025021008063717400_r9","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.4049\/jimmunol.162.9.5317","article-title":"Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance","volume":"162","author":"Itoh","year":"1999","journal-title":"J. Immunol."},{"key":"2025021008063717400_r10","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"2025021008063717400_r11","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","article-title":"Foxp3 programs the development and function of CD4+CD25+ regulatory T cells","volume":"4","author":"Fontenot","year":"2003","journal-title":"Nat. Immunol."},{"key":"2025021008063717400_r12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ni909","article-title":"An essential role for Scurfin in CD4+CD25+ T regulatory cells","volume":"4","author":"Khattri","year":"2003","journal-title":"Nat. Immunol."},{"key":"2025021008063717400_r13","doi-asserted-by":"crossref","first-page":"944","DOI":"10.4049\/immunohorizons.2100046","article-title":"Toward a paradigm to distinguish distinct functions of FOXP3+ regulatory T cells","volume":"5","author":"Weinberg","year":"2021","journal-title":"Immunohorizons"},{"key":"2025021008063717400_r14","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1126\/science.aau2688","article-title":"Treg cells\u2014the next frontier of cell therapy","volume":"362","author":"Bluestone","year":"2018","journal-title":"Science"},{"key":"2025021008063717400_r15","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nri3667","article-title":"Positive and negative selection of the T cell repertoire: what thymocytes see (and don\u2019t see)","volume":"14","author":"Klein","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"2025021008063717400_r16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev-immunol-020711-075035","article-title":"Selection of self-reactive T cells in the thymus","volume":"30","author":"Stritesky","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"2025021008063717400_r17","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.4049\/jimmunol.1700892","article-title":"Mode of tolerance induction and requirement for Aire are governed by the cell types that express self-antigen and those that present antigen","volume":"199","author":"Mouri","year":"2017","journal-title":"J. Immunol."},{"key":"2025021008063717400_r18","doi-asserted-by":"crossref","first-page":"eabf3111","DOI":"10.1126\/sciimmunol.abf3111","article-title":"Protection against autoimmunity is driven by thymic epithelial cell-mediated regulation of Treg development","volume":"6","author":"Haftmann","year":"2021","journal-title":"Sci. Immunol."},{"key":"2025021008063717400_r19","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.immuni.2016.01.025","article-title":"Dendritic cells coordinate the development and homeostasis of organ-specific regulatory T cells","volume":"44","author":"Leventhal","year":"2016","journal-title":"Immunity"},{"key":"2025021008063717400_r20","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.immuni.2018.04.007","article-title":"Transfer of cell-surface antigens by scavenger receptor CD36 promotes thymic regulatory T cell receptor repertoire development and allo-tolerance. [Published erratum appears in 2018 Immunity 48: 1271.]","volume":"48","author":"Perry","year":"2018","journal-title":"Immunity"},{"key":"2025021008063717400_r21","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1084\/jem.20082449","article-title":"The thymic medulla: a unique microenvironment for intercellular self-antigen transfer","volume":"206","author":"Koble","year":"2009","journal-title":"J. Exp. Med."},{"key":"2025021008063717400_r22","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.4049\/jimmunol.1501000","article-title":"Aire expression is inherent to most medullary thymic epithelial cells during their differentiation program","volume":"195","author":"Kawano","year":"2015","journal-title":"J. Immunol."},{"key":"2025021008063717400_r23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1074-7613(02)00365-5","article-title":"In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens","volume":"17","author":"Jung","year":"2002","journal-title":"Immunity"},{"key":"2025021008063717400_r24","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.4049\/jimmunol.1800950","article-title":"Aire controls in trans the production of medullary thymic epithelial cells expressing Ly-6C\/Ly-6G","volume":"201","author":"Morimoto","year":"2018","journal-title":"J. Immunol."},{"key":"2025021008063717400_r25","doi-asserted-by":"crossref","first-page":"110384","DOI":"10.1016\/j.celrep.2022.110384","article-title":"Aire suppresses CTLA-4 expression from the thymic stroma to control autoimmunity","volume":"38","author":"Morimoto","year":"2022","journal-title":"Cell Rep."},{"key":"2025021008063717400_r26","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.4049\/jimmunol.1302786","article-title":"Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program","volume":"192","author":"Nishikawa","year":"2014","journal-title":"J. Immunol."},{"key":"2025021008063717400_r27","doi-asserted-by":"crossref","first-page":"e73998","DOI":"10.7554\/eLife.73998","article-title":"Integrative analysis of scRNA-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator","volume":"11","author":"Miyao","year":"2022","journal-title":"eLife"},{"key":"2025021008063717400_r28","doi-asserted-by":"crossref","first-page":"303","DOI":"10.4049\/jimmunol.2100692","article-title":"Aire controls heterogeneity of medullary thymic epithelial cells for the expression of self-antigens","volume":"208","author":"Nishijima","year":"2022","journal-title":"J. Immunol."},{"key":"2025021008063717400_r29","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41590-018-0289-6","article-title":"Thymic regulatory T cells arise via two distinct developmental programs","volume":"20","author":"Owen","year":"2019","journal-title":"Nat. Immunol."},{"key":"2025021008063717400_r30","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/ni.3522","article-title":"Affinity for self antigen selects Treg cells with distinct functional properties","volume":"17","author":"Wyss","year":"2016","journal-title":"Nat. Immunol."},{"key":"2025021008063717400_r31","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.3389\/fimmu.2019.02382","article-title":"Dynamic imprinting of the Treg cell-specific epigenetic signature in developing thymic regulatory T cells","volume":"10","author":"Herppich","year":"2019","journal-title":"Front. Immunol."},{"key":"2025021008063717400_r32","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.immuni.2012.09.010","article-title":"T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development","volume":"37","author":"Ohkura","year":"2012","journal-title":"Immunity"},{"key":"2025021008063717400_r33","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.immuni.2014.08.007","article-title":"Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus","volume":"41","author":"Perry","year":"2014","journal-title":"Immunity"},{"key":"2025021008063717400_r34","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1084\/jem.20131889","article-title":"Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance","volume":"211","author":"Khan","year":"2014","journal-title":"J. Exp. Med."},{"key":"2025021008063717400_r35","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.immuni.2007.11.021","article-title":"A two-step process for thymic regulatory T cell development","volume":"28","author":"Lio","year":"2008","journal-title":"Immunity"},{"key":"2025021008063717400_r36","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/ni.2849","article-title":"Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells","volume":"15","author":"Mahmud","year":"2014","journal-title":"Nat. Immunol."},{"key":"2025021008063717400_r37","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.4049\/jimmunol.1200586","article-title":"Identification of IL-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice","volume":"189","author":"Hara","year":"2012","journal-title":"J. Immunol."},{"key":"2025021008063717400_r38","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/eji.201747375","article-title":"Aire controls the recirculation of murine Foxp3+ regulatory T-cells back to the thymus","volume":"48","author":"Cowan","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"2025021008063717400_r39","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S1471-4906(02)02248-2","article-title":"Promiscuous gene expression and central T-cell tolerance: more than meets the eye","volume":"23","author":"Kyewski","year":"2002","journal-title":"Trends Immunol."},{"key":"2025021008063717400_r40","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.4049\/jimmunol.0900438","article-title":"Crucial contribution of thymic Sirp\u03b1+ conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent manner","volume":"183","author":"Baba","year":"2009","journal-title":"J. Immunol."},{"key":"2025021008063717400_r41","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.immuni.2012.01.017","article-title":"Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance","volume":"36","author":"Hadeiba","year":"2012","journal-title":"Immunity"},{"key":"2025021008063717400_r42","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1038\/s41590-020-0756-8","article-title":"Fibroblasts as a source of self-antigens for central immune tolerance","volume":"21","author":"Nitta","year":"2020","journal-title":"Nat. Immunol."},{"key":"2025021008063717400_r43","doi-asserted-by":"crossref","first-page":"6250","DOI":"10.4049\/jimmunol.161.11.6250","article-title":"CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (\u03b1v\u03b23)","volume":"161","author":"Fadok","year":"1998","journal-title":"J. Immunol."},{"key":"2025021008063717400_r44","doi-asserted-by":"crossref","first-page":"672","DOI":"10.3389\/fimmu.2014.00672","article-title":"Antigen presentation by MHC-dressed cells","volume":"5","author":"Nakayama","year":"2015","journal-title":"Front. Immunol."},{"key":"2025021008063717400_r45","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4049\/jimmunol.1601516","article-title":"Thymic dendritic cell subsets display distinct efficiencies and mechanisms of intercellular MHC transfer","volume":"198","author":"Kroger","year":"2017","journal-title":"J. Immunol."},{"key":"2025021008063717400_r46","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1002\/eji.200737982","article-title":"Intercellular MHC transfer between thymic epithelial and dendritic cells","volume":"38","author":"Millet","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"2025021008063717400_r47","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3389\/fimmu.2015.00366","article-title":"Exosomes in the thymus: antigen transfer and vesicles","volume":"6","author":"Skogberg","year":"2015","journal-title":"Front. Immunol."},{"key":"2025021008063717400_r48","doi-asserted-by":"crossref","first-page":"7014","DOI":"10.4049\/jimmunol.181.10.7014","article-title":"Thymocyte-dendritic cell interactions near sources of CCR7 ligands in the thymic cortex","volume":"181","author":"Ladi","year":"2008","journal-title":"J. Immunol."},{"key":"2025021008063717400_r49","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0092-8674(00)81028-4","article-title":"The repertoire of T cells shaped by a single MHC\/peptide ligand","volume":"84","author":"Ignatowicz","year":"1996","journal-title":"Cell"},{"key":"2025021008063717400_r50","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00251-019-01127-8","article-title":"How does the immune system learn to distinguish between good and evil? The first definitive studies of T cell central tolerance and positive selection","volume":"71","author":"Kisielow","year":"2019","journal-title":"Immunogenetics"},{"key":"2025021008063717400_r51","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.4049\/jimmunol.1501026","article-title":"Ectopic Aire expression in the thymic cortex reveals inherent properties of Aire as a tolerogenic factor within the medulla","volume":"195","author":"Nishijima","year":"2015","journal-title":"J. Immunol."},{"key":"2025021008063717400_r52","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.4049\/jimmunol.1400389","article-title":"NF-\u03baB-inducing kinase in thymic stroma establishes central tolerance by orchestrating cross-talk with not only thymocytes but also dendritic cells","volume":"193","author":"Mouri","year":"2014","journal-title":"J. Immunol."},{"key":"2025021008063717400_r53","doi-asserted-by":"crossref","first-page":"6264","DOI":"10.1038\/s41467-020-20070-x","article-title":"B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms","volume":"11","author":"Watanabe","year":"2020","journal-title":"Nat. Commun."},{"key":"2025021008063717400_r54","doi-asserted-by":"crossref","first-page":"5368","DOI":"10.1038\/s41467-018-07806-6","article-title":"Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape","volume":"9","author":"Chorro","year":"2018","journal-title":"Nat. Commun."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/210\/11\/1653\/61468480\/ji2200780.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/210\/11\/1653\/61468480\/ji2200780.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T08:12:59Z","timestamp":1739175179000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/210\/11\/1653\/7930433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,17]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,6,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2200780","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,6]]},"published":{"date-parts":[[2023,4,17]]}}}