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The thymic functions of iNKT1 cells are not fully elucidated, but subsets of thymic iNKT cells modulate CD8 T cell, dendritic cell, B cell, and thymic epithelial cell numbers or function. In this study, we show that a subset of murine thymic iNKT1 cells required TGF-\u03b2\u2013induced signals for their postselection development, to maintain hallmark TGF-\u03b2\u2013induced genes, and for expression of the adhesion receptors CD49a and CD103. However, the residency-associated receptor CD69 was not TGF-\u03b2 signaling\u2013dependent. Recently described CD244+ c2 thymic iNKT1 cells, which produce IFN-\u03b3 without exogenous stimulation and have NK-like characteristics, reside in this TGF-\u03b2\u2013responsive population. Liver and spleen iNKT1 cells do not share this TGF-\u03b2 gene signature, but nonetheless TGF-\u03b2 impacts liver iNKT1 cell phenotype and function. Our findings provide insight into the heterogeneity of mechanisms guiding iNKT1 cell development in different tissues and suggest a close association between a subset of iNKT1 cells and TGF-\u03b2\u2013producing cells in the thymus that support their development.<\/jats:p>","DOI":"10.4049\/jimmunol.2200809","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T15:06:27Z","timestamp":1694617587000},"page":"1376-1384","source":"Crossref","is-referenced-by-count":7,"title":["TGF-\u03b2 Promotes the Postselection Thymic Development and Peripheral Function of IFN-\u03b3\u2013Producing Invariant NKT cells"],"prefix":"10.1093","volume":"211","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9006-9225","authenticated-orcid":false,"given":"Roxroy C","family":"Morgan","sequence":"first","affiliation":[{"name":"Committee on Genetics, Genomics and Systems Biology, The University of Chicago , Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Chicago , Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munmun","family":"Greger","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Chicago , Chicago, IL"},{"name":"Committees on Cancer Biology and Immunology, The University of Chicago , Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1124-2024","authenticated-orcid":false,"given":"Mary","family":"Attaway","sequence":"additional","affiliation":[{"name":"Committees on Cancer Biology and Immunology, The University of Chicago , Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8527-7276","authenticated-orcid":false,"given":"Mikael","family":"Sigvardsson","sequence":"additional","affiliation":[{"name":"Department of Molecular Hematology, Lund University , Lund ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-2582","authenticated-orcid":false,"given":"Elizabeth T","family":"Bartom","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, Northwestern Feinberg School of Medicine , Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7014-1982","authenticated-orcid":false,"given":"Barbara L","family":"Kee","sequence":"additional","affiliation":[{"name":"Committee on Genetics, Genomics and Systems Biology, The University of Chicago , Chicago, IL"},{"name":"Department of Pathology, The University of Chicago , Chicago, IL"},{"name":"Committees on Cancer Biology and Immunology, The University of Chicago , Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"2025020406164453300_r1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.molimm.2018.09.023","article-title":"The ins and outs of type I iNKT cell development","volume":"105","author":"Shissler","year":"2019","journal-title":"Mol. 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