{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T02:41:44Z","timestamp":1787452904628,"version":"build-2736575974"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100015691","name":"HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI123947"],"award-info":[{"award-number":["R01AI123947"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI160896"],"award-info":[{"award-number":["R01AI160896"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI129788"],"award-info":[{"award-number":["R01AI129788"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM103641"],"award-info":[{"award-number":["P20GM103641"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI123947-S2 to BH"],"award-info":[{"award-number":["R01 AI123947-S2 to BH"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>During endotoxin-induced acute lung injury (ALI), immune cell recruitment resulting from chemotaxis is mediated by CXC and CC chemokines and their receptors. In this study, we investigated the role of chemokines and their receptors in the regulation of myeloid cell populations in the circulation and the lungs of C57BL\/6J mice exhibiting LPS-mediated ALI using single-cell RNA sequencing. During ALI, there was an increase in the myeloid cells, M1 macrophages, monocytes, neutrophils, and other granulocytes, whereas there was a decrease in the residential alveolar macrophages and M2 macrophages. Interestingly, LPS triggered the upregulation of CCL3, CCL4, CXCL2\/3, and CXCL10 genes associated with cellular migration of various subsets of macrophages, neutrophils, and granulocytes. Furthermore, there was an increase in the frequency of myeloid cells expressing CCR1, CCR3, CCR5, and CXCR2 receptors during ALI. MicroRNA sequencing studies of vehicle versus LPS groups identified several dysregulated microRNAs targeting the upregulated chemokine genes. This study suggests that chemokine ligand\u2013receptors interactions are responsible for myeloid cell heterogenicity and cellular recruitment to the lungs during ALI. The single-cell transcriptomics allowed for an in-depth assessment and characterization of myeloid cells involved in immune cell trafficking during ALI.<\/jats:p>","DOI":"10.4049\/jimmunol.2200822","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T15:52:39Z","timestamp":1683733959000},"page":"2016-2028","source":"Crossref","is-referenced-by-count":10,"title":["Characterization of Chemotaxis-Associated Gene Dysregulation in Myeloid Cell Populations in the Lungs during Lipopolysaccharide-Mediated Acute Lung Injury"],"prefix":"10.1093","volume":"210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9891-9001","authenticated-orcid":false,"given":"Bryan Latrell","family":"Holloman","sequence":"first","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine , Columbia, SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9558-603X","authenticated-orcid":false,"given":"Alkeiver","family":"Cannon","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine , Columbia, SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8550-3739","authenticated-orcid":false,"given":"Kiesha","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine , Columbia, SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narendra","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine , Columbia, SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5977-5615","authenticated-orcid":false,"given":"Mitzi","family":"Nagarkatti","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine , Columbia, SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2663-0759","authenticated-orcid":false,"given":"Prakash","family":"Nagarkatti","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine , Columbia, SC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,10]]},"reference":[{"key":"2025021008070741000_r1","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1016\/j.bbamcr.2014.05.014","article-title":"Cytokines and chemokines: at the crossroads of cell signalling and inflammatory disease","volume":"1843","author":"Turner","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"2025021008070741000_r2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/0300985812469883","article-title":"Getting leukocytes to the site of inflammation","volume":"50","author":"Muller","year":"2013","journal-title":"Vet. Pathol."},{"key":"2025021008070741000_r3","doi-asserted-by":"crossref","first-page":"a016303","DOI":"10.1101\/cshperspect.a016303","article-title":"The chemokine system in innate immunity","volume":"7","author":"Sokol","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2025021008070741000_r4","first-page":"28","volume-title":"Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infectious Diseases.","author":"Embry","year":"2020"},{"key":"2025021008070741000_r5","doi-asserted-by":"crossref","first-page":"E7059","DOI":"10.1073\/pnas.1615671113","article-title":"Serum stimulation of CCR7 chemotaxis due to coagulation factor XIIa-dependent production of high-molecular-weight kininogen domain 5","volume":"113","author":"Ponda","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025021008070741000_r6","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.3389\/fimmu.2020.01259","article-title":"Multiple roles for chemokines in neutrophil biology","volume":"11","author":"Capucetti","year":"2020","journal-title":"Front. Immunol."},{"key":"2025021008070741000_r7","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3389\/fimmu.2014.00491","article-title":"Macrophage cytokines: involvement in immunity and infectious diseases","volume":"5","author":"Arango Duque","year":"2014","journal-title":"Front. Immunol."},{"key":"2025021008070741000_r8","doi-asserted-by":"crossref","first-page":"L3","DOI":"10.1152\/ajplung.00405.2003","article-title":"Chemokines in acute respiratory distress syndrome","volume":"288","author":"Puneet","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2025021008070741000_r9","doi-asserted-by":"crossref","first-page":"L350","DOI":"10.1152\/ajplung.00061.2004","article-title":"CCR2-positive monocytes recruited to inflamed lungs downregulate local CCL2 chemokine levels","volume":"288","author":"Maus","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2025021008070741000_r10","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.4049\/jimmunol.170.6.3273","article-title":"Monocytes are potent facilitators of alveolar neutrophil emigration during lung inflammation: role of the CCL2-CCR2 axis","volume":"170","author":"Maus","year":"2003","journal-title":"J. Immunol."},{"key":"2025021008070741000_r11","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1164\/rccm.2112012","article-title":"The role of CC chemokine receptor 2 in alveolar monocyte and neutrophil immigration in intact mice","volume":"166","author":"Maus","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025021008070741000_r12","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1002\/eji.200425294","article-title":"CC chemokine receptor 2 regulates leukocyte recruitment and IL-10 production during acute polymicrobial sepsis","volume":"34","author":"Feterowski","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"2025021008070741000_r13","doi-asserted-by":"crossref","first-page":"5078","DOI":"10.1111\/bph.15226","article-title":"Protective effects of \u03949 -tetrahydrocannabinol against enterotoxin-induced acute respiratory distress syndrome are mediated by modulation of microbiota","volume":"177","author":"Mohammed","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"2025021008070741000_r14","doi-asserted-by":"crossref","first-page":"101504","DOI":"10.1016\/j.isci.2020.101504","article-title":"Activation of cannabinoid receptor 2 prevents colitis-associated colon cancer through myeloid cell de-activation upstream of IL-22 production","volume":"23","author":"Becker","year":"2020","journal-title":"iScience"},{"key":"2025021008070741000_r15","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01666-14","article-title":"Staphylococcal enterotoxin B-induced microRNA-155 targets SOCS1 to promote acute inflammatory lung injury. [Published erratum appears in 2014 Infect. Immun. DOI: 10.1128\/IAI.02193-14.]","author":"Rao","year":"2014","journal-title":"Infect. Immun."},{"key":"2025021008070741000_r16","doi-asserted-by":"crossref","first-page":"e0313722","DOI":"10.1128\/mbio.03137-22","article-title":"Aryl hydrocarbon receptor activation ameliorates acute respiratory distress syndrome through regulation of Th17 and Th22 cells in the lungs","volume":"2023","author":"Holloman","year":"2023","journal-title":"mBio"},{"key":"2025021008070741000_r17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cell.2020.11.025","article-title":"Synergism of TNF-\u03b1 and IFN-\u03b3 triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes","volume":"184","author":"Karki","year":"2021","journal-title":"Cell"},{"key":"2025021008070741000_r18","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s13054-020-02911-9","article-title":"Acute respiratory failure in COVID-19: is it \u201ctypical\u201d ARDS?","volume":"24","author":"Li","year":"2020","journal-title":"Crit. Care"},{"key":"2025021008070741000_r19","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"2025021008070741000_r20","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00018-020-03656-y","article-title":"TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling","volume":"78","author":"Ciesielska","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"2025021008070741000_r21","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.chom.2020.04.009","article-title":"Complex immune dysregulation in COVID-19 patients with severe respiratory failure","volume":"27","author":"Giamarellos-Bourboulis","year":"2020","journal-title":"Cell Host Microbe"},{"key":"2025021008070741000_r22","volume-title":"Acute Respiratory Distress Syndrome","author":"Diamond","year":"2022"},{"key":"2025021008070741000_r23","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1631\/jzus.2007.B0060","article-title":"Acute lung injury\/acute respiratory distress syndrome (ALI\/ARDS): the mechanism, present strategies and future perspectives of therapies","volume":"8","author":"Luh","year":"2007","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"2025021008070741000_r24","doi-asserted-by":"crossref","first-page":"644281","DOI":"10.3389\/fphar.2021.644281","article-title":"The endocannabinoid anandamide attenuates acute respiratory distress syndrome by downregulating miRNA that target inflammatory pathways","volume":"12","author":"Sultan","year":"2021","journal-title":"Front. Pharmacol."},{"key":"2025021008070741000_r25","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.3390\/cells10123305","article-title":"Endocannabinoid anandamide attenuates acute respiratory distress syndrome through modulation of microbiome in the gut-lung axis","volume":"10","author":"Sultan","year":"2021","journal-title":"Cells"},{"key":"2025021008070741000_r26","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/S2213-2600(20)30505-1","article-title":"Pathophysiology of COVID-19-associated acute respiratory distress syndrome","volume":"9","author":"Camporota","year":"2021","journal-title":"Lancet Respir. Med."},{"key":"2025021008070741000_r27","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/s41587-020-0602-4","article-title":"COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis","volume":"38","author":"Chua","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"2025021008070741000_r28","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/s41591-020-0901-9","article-title":"Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19","volume":"26","author":"Liao","year":"2020","journal-title":"Nat. Med."},{"key":"2025021008070741000_r29","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/cid\/ciaa248","article-title":"Dysregulation of immune response in patients with coronavirus 2019 (COVID-19) in Wuhan, China","volume":"71","author":"Qin","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"2025021008070741000_r30","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/ni1102-1033","article-title":"Bacterial strategies for overcoming host innate and adaptive immune responses","volume":"3","author":"Hornef","year":"2002","journal-title":"Nat. Immunol."},{"key":"2025021008070741000_r31","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2119\/molmed.2010.00138","article-title":"Contribution of neutrophils to acute lung injury","volume":"17","author":"Grommes","year":"2011","journal-title":"Mol. Med."},{"key":"2025021008070741000_r32","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/s41385-021-00397-4","article-title":"Neutrophils in respiratory viral infections","volume":"14","author":"Johansson","year":"2021","journal-title":"Mucosal Immunol."},{"key":"2025021008070741000_r33","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cellsig.2018.11.004","article-title":"How do chemokines navigate neutrophils to the target site: dissecting the structural mechanisms and signaling pathways","volume":"54","author":"Rajarathnam","year":"2019","journal-title":"Cell. Signal."},{"key":"2025021008070741000_r34","doi-asserted-by":"crossref","first-page":"5211","DOI":"10.4049\/jimmunol.1401844","article-title":"Critical role of mast cells and peroxisome proliferator-activated receptor \u03b3 in the induction of myeloid-derived suppressor cells by marijuana cannabidiol in vivo","volume":"194","author":"Hegde","year":"2015","journal-title":"J. Immunol."},{"key":"2025021008070741000_r35","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.immuni.2015.03.007","article-title":"Lipopolysaccharide Induces Alveolar Macrophage Necrosis via CD14 and the P2X7 Receptor Leading to Interleukin-1\u03b1 Release","volume":"42","author":"Dagvadorj","year":"2015","journal-title":"Immunity"},{"key":"2025021008070741000_r36","doi-asserted-by":"crossref","first-page":"L379","DOI":"10.1152\/ajplung.00010.2008","article-title":"Animal models of acute lung injury","volume":"295","author":"Matute-Bello","year":"2008","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2025021008070741000_r37","doi-asserted-by":"crossref","first-page":"1901298","DOI":"10.1183\/13993003.01298-2019","article-title":"Human lipopolysaccharide models provide mechanistic and therapeutic insights into systemic and pulmonary inflammation","volume":"56","author":"Brooks","year":"2020","journal-title":"Eur. Respir. J."},{"key":"2025021008070741000_r38","doi-asserted-by":"crossref","first-page":"557","DOI":"10.12688\/f1000research.18411.1","article-title":"Understanding the role of neutrophils in chronic inflammatory airway disease","volume":"8","author":"Jasper","year":"2019","journal-title":"F1000Res."},{"key":"2025021008070741000_r39","doi-asserted-by":"crossref","first-page":"4930","DOI":"10.1182\/blood-2013-02-486217","article-title":"Mast cell and macrophage chemokines CXCL1\/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation","volume":"121","author":"De Filippo","year":"2013","journal-title":"Blood"},{"key":"2025021008070741000_r40","article-title":"CXCL3\u2014an overview","author":"Science Direct"},{"key":"2025021008070741000_r41","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.4049\/jimmunol.1203421","article-title":"Differential roles of CXCL2 and CXCL3 and their receptors in regulating normal and asthmatic airway smooth muscle cell migration","volume":"191","author":"Al-Alwan","year":"2013","journal-title":"J. Immunol."},{"key":"2025021008070741000_r42","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.immuni.2018.09.018","article-title":"Distinct compartmentalization of the chemokines CXCL1 and CXCL2 and the atypical receptor ACKR1 determine discrete stages of neutrophil diapedesis","volume":"49","author":"Girbl","year":"2018","journal-title":"Immunity"},{"key":"2025021008070741000_r43","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41423-020-0412-0","article-title":"Neutrophil chemoattractant receptors in health and disease: double-edged swords","volume":"17","author":"Metzemaekers","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"2025021008070741000_r44","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.3390\/ijms20184658","article-title":"The cooperative induction of CCL4 in human monocytic cells by TNF-\u03b1 and palmitate requires MyD88 and involves MAPK\/NF-\u03baB signaling pathways","volume":"20","author":"Sindhu","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2025021008070741000_r45","doi-asserted-by":"crossref","first-page":"e1000755","DOI":"10.1371\/journal.ppat.1000755","article-title":"Neutrophil-derived CCL3 is essential for the rapid recruitment of dendritic cells to the site of Leishmania major inoculation in resistant mice","volume":"6","author":"Charmoy","year":"2010","journal-title":"PLoS Pathog."},{"key":"2025021008070741000_r46","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.bone.2009.12.030","article-title":"Evidences of the cooperative role of the chemokines CCL3, CCL4 and CCL5 and its receptors CCR1+ and CCR5+ in RANKL+ cell migration throughout experimental periodontitis in mice","volume":"46","author":"Repeke","year":"2010","journal-title":"Bone"},{"key":"2025021008070741000_r47","doi-asserted-by":"crossref","first-page":"6710278","DOI":"10.1155\/2017\/6710278","article-title":"Advanced role of neutrophils in common respiratory diseases","volume":"2017","author":"Liu","year":"2017","journal-title":"J. Immunol. Res."},{"key":"2025021008070741000_r48","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00011-010-0193-5","article-title":"The role of the CCR1 receptor in the inflammatory response to tobacco smoke in a mouse model","volume":"59","author":"\u00d6nnervik","year":"2010","journal-title":"Inflamm. Res."},{"key":"2025021008070741000_r49","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3389\/fcimb.2019.00108","article-title":"Neutrophils induce a novel chemokine receptors repertoire during influenza pneumonia","volume":"9","author":"Rudd","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"2025021008070741000_r50","first-page":"101077","article-title":"Effects of blocking chemokine receptor CCR1 with BX471 in two models of fibrosis prevention and rescue in mice","volume":"27","author":"Weber","year":"2021","journal-title":"Biochem. Biophys. Rep."},{"key":"2025021008070741000_r51","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1165\/rcmb.2010-0265OC","article-title":"The chemokine, CCL3, and its receptor, CCR1, mediate thoracic radiation-induced pulmonary fibrosis","volume":"45","author":"Yang","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2025021008070741000_r52","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1164\/rccm.201203-0508OC","article-title":"CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin","volume":"187","author":"Ichikawa","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025021008070741000_r53","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.3389\/fimmu.2017.01970","article-title":"Overview of the mechanisms that may contribute to the non-redundant activities of interferon-inducible CXC chemokine receptor 3 ligands","volume":"8","author":"Metzemaekers","year":"2018","journal-title":"Front. Immunol."},{"key":"2025021008070741000_r54","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1189\/jlb.0405221","article-title":"TNF-alpha-induced chemokine production and apoptosis in human neural precursor cells","volume":"78","author":"Sheng","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"2025021008070741000_r55","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1165\/rcmb.2011-0392TR","article-title":"Role of chemokines in the pathogenesis of acute lung injury","volume":"46","author":"Bhatia","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2025021008070741000_r56","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1189\/jlb.69.2.248","article-title":"Increase of CCR1 and CCR5 expression and enhanced functional response to MIP-1 alpha during differentiation of human monocytes to macrophages","volume":"69","author":"Kaufmann","year":"2001","journal-title":"J. Leukoc. Biol."},{"key":"2025021008070741000_r57","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.joca.2020.01.009","article-title":"CCL3\/CCR1 mediates CD14+CD16\u2212 circulating monocyte recruitment in knee osteoarthritis progression","volume":"28","author":"Zhao","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"key":"2025021008070741000_r58","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.immuni.2019.01.009","article-title":"Chemokine receptor redundancy and specificity are context dependent","volume":"50","author":"Dyer","year":"2019","journal-title":"Immunity"},{"key":"2025021008070741000_r59","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.3389\/fimmu.2018.01930","article-title":"Chemokine-induced macrophage polarization in inflammatory conditions","volume":"9","author":"Ruytinx","year":"2018","journal-title":"Front. Immunol."},{"key":"2025021008070741000_r60","article-title":"CCL4\u2014an overview","author":"Science Direct"},{"key":"2025021008070741000_r61","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s41419-018-0562-5","article-title":"CCL4 enhances preosteoclast migration and its receptor CCR5 downregulation by RANKL promotes osteoclastogenesis","volume":"9","author":"Lee","year":"2018","journal-title":"Cell Death Dis."},{"key":"2025021008070741000_r62","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cellimm.2006.12.001","article-title":"CCR5 expression on monocytes and T cells: modulation by transmigration across the blood-brain barrier in vitro","volume":"243","author":"Ubogu","year":"2006","journal-title":"Cell. Immunol."},{"key":"2025021008070741000_r63","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.3390\/cancers12061383","article-title":"Eotaxins and their receptor in colorectal cancer\u2014a literature review","volume":"12","author":"Zajkowska","year":"2020","journal-title":"Cancers (Basel)"},{"key":"2025021008070741000_r64","doi-asserted-by":"crossref","first-page":"C264","DOI":"10.1152\/ajpcell.00461.2004","article-title":"Mechanism of amyloid peptide induced CCR5 expression in monocytes and its inhibition by siRNA for Egr-1","volume":"289","author":"Giri","year":"2005","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2025021008070741000_r65","doi-asserted-by":"crossref","first-page":"508","DOI":"10.3389\/fimmu.2014.00508","article-title":"Neutrophil-derived cytokines: facts beyond expression","volume":"5","author":"Tecchio","year":"2014","journal-title":"Front. Immunol."},{"key":"2025021008070741000_r66","doi-asserted-by":"crossref","first-page":"6364","DOI":"10.1128\/IAI.69.10.6364-6369.2001","article-title":"Macrophage inflammatory protein 1\u03b1\/CCL3 is required for clearance of an acute Klebsiella pneumoniae pulmonary infection","volume":"69","author":"Lindell","year":"2001","journal-title":"Infect. Immun."},{"key":"2025021008070741000_r67","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00441-010-1049-6","article-title":"Eosinophils in innate immunity: an evolving story","volume":"343","author":"Shamri","year":"2011","journal-title":"Cell Tissue Res."},{"key":"2025021008070741000_r68","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/cea.13382","article-title":"Critical role of CCL4 in eosinophil recruitment into the airway","volume":"49","author":"Kobayashi","year":"2019","journal-title":"Clin. Exp. Allergy"},{"key":"2025021008070741000_r69","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s12974-016-0699-z","article-title":"MicroRNA-155 enhances T cell trafficking and antiviral effector function in a model of coronavirus-induced neurologic disease","volume":"13","author":"Dickey","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"2025021008070741000_r70","doi-asserted-by":"crossref","first-page":"7221","DOI":"10.1074\/jbc.R115.708842","article-title":"Extracellular RNAs: a secret arm of immune system regulation","volume":"291","author":"de Candia","year":"2016","journal-title":"J. Biol. Chem."},{"key":"2025021008070741000_r71","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.dadm.2015.11.004","article-title":"MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer\u2019s disease","volume":"3","author":"Guedes","year":"2015","journal-title":"Alzheimers Dement. (Amst.)"},{"key":"2025021008070741000_r72","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/art.38269","article-title":"MicroRNA-451 down-regulates neutrophil chemotaxis via p38 MAPK","volume":"66","author":"Murata","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"2025021008070741000_r73","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1080\/13102818.2020.1738955","article-title":"MicroRNA-421 affects the chemotaxis of monocytes via MCP-1, and regulates the local immune responses in injured cartilage site of elbow joint of upper limbs","volume":"34","author":"Zhu","year":"2020","journal-title":"Biotechnol. Biotechnol. Equip."},{"key":"2025021008070741000_r74","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.chom.2020.04.017","article-title":"Heightened innate immune responses in the respiratory tract of COVID-19 patients","volume":"27","author":"Zhou","year":"2020","journal-title":"Cell Host Microbe"},{"key":"2025021008070741000_r75","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s10020-020-00230-x","article-title":"IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19","volume":"26","author":"Chen","year":"2020","journal-title":"Mol. Med."},{"key":"2025021008070741000_r76","doi-asserted-by":"crossref","first-page":"621","DOI":"10.4049\/jimmunol.177.1.621","article-title":"Gender differences in murine airway responsiveness and lipopolysaccharide-induced inflammation","volume":"177","author":"Card","year":"2006","journal-title":"J. Immunol."},{"key":"2025021008070741000_r77","doi-asserted-by":"crossref","first-page":"15884","DOI":"10.1038\/s41598-020-72537-y","article-title":"Sex differences of inflammatory and immune response in pups of Wistar rats with SIRS","volume":"10","author":"Kosyreva","year":"2020","journal-title":"Sci. Rep."},{"key":"2025021008070741000_r78","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jri.2006.01.004","article-title":"Sexual dimorphism in expression of receptors for bacterial lipopolysaccharides in murine macrophages: a possible mechanism for gender-based differences in endotoxic shock susceptibility","volume":"71","author":"Marriott","year":"2006","journal-title":"J. Reprod. Immunol."},{"key":"2025021008070741000_r79","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1095\/biolreprod.107.063545","article-title":"Testosterone reduces macrophage expression in the mouse of toll-like receptor 4, a trigger for inflammation and innate immunity","volume":"78","author":"Rettew","year":"2008","journal-title":"Biol. Reprod."},{"key":"2025021008070741000_r80","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nat. Rev. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/210\/12\/2016\/61469434\/ji2200822.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/210\/12\/2016\/61469434\/ji2200822.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T08:13:54Z","timestamp":1739175234000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/210\/12\/2016\/7932655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,10]]},"references-count":80,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,6,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2200822","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,6]]},"published":{"date-parts":[[2023,5,10]]}}}