{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T12:14:15Z","timestamp":1792239255683,"version":"4.4.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31870907"],"award-info":[{"award-number":["31870907"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930041"],"award-info":[{"award-number":["81930041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91842103"],"award-info":[{"award-number":["91842103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703135"],"award-info":[{"award-number":["81703135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771699"],"award-info":[{"award-number":["81771699"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"MOST | NSFC | NSFC-Zhejiang Joint Fund | \u6d59\u6c5f\u7701\u79d1\u5b66\u6280\u672f\u5385 | Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["Z19H100001"],"award-info":[{"award-number":["Z19H100001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Dendritic cells (DCs), a driver of psoriasis pathogenesis, produce IL-23 and trigger IL-23\/IL-17 cytokine axis activation. However, the mechanisms regulating IL-23 induction remain unclear. In the current study, we found that mice with E3 ligase FBXW7 deficiency in DCs show reduced skin inflammation correlated with the reduction of IL-23\/IL-17 axis cytokines in the imiquimod-induced psoriasis model. Fbxw7 deficiency results in decreased production of IL-23 in DCs. FBXW7 interacts with the lysine N-methyltransferase suppressor of variegation 39 homolog 2 (SUV39H2), which catalyzes the trimethylation of histone H3 Lys9 (H3K9) during transcription regulation. FBXW7 mediates the ubiquitination and degradation of SUV39H2, thus decreasing H3K9m3 deposition on the Il23a promoter. The Suv39h2 knockout mice displayed exacerbated skin inflammation with the IL-23\/IL-17 axis overactivating in the psoriasis model. Taken together, our results indicate that FBXW7 increases IL-23 expression in DCs by degrading SUV39H2, thereby aggravating psoriasis-like inflammation. Inhibition of FBXW7 or the FBXW7\/SUV39H2\/IL-23 axis may represent a novel therapeutic approach to psoriasis.<\/jats:p>","DOI":"10.4049\/jimmunol.2300023","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T14:33:58Z","timestamp":1697466838000},"page":"1701-1713","source":"Crossref","is-referenced-by-count":7,"title":["Epigenetic Regulation of IL-23 by E3 Ligase FBXW7 in Dendritic Cells Is Critical for Psoriasis-like Inflammation"],"prefix":"10.1093","volume":"211","author":[{"given":"Yinjing","family":"Song","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangtong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7633-7097","authenticated-orcid":false,"given":"Hao","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9917-0488","authenticated-orcid":false,"given":"Yixin","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6346-4107","authenticated-orcid":false,"given":"Rukun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luxia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutong","family":"Fang","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7042-8034","authenticated-orcid":false,"given":"Jiaying","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Zou","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular Disease, Department of Pathophysiology, Nanjing Medical University , Nanjing ,","place":["China"]},{"name":"Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Pathophysiology, Nanjing Medical University , Nanjing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaohan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Macau SAR ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular Disease, Department of Pathophysiology, Nanjing Medical University , Nanjing ,","place":["China"]},{"name":"Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Pathophysiology, Nanjing Medical University , Nanjing ,","place":["China"]},{"name":"Institute of Biomedical Research, Liaocheng University , Liaocheng ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]},{"name":"Department of Pharmacology, Zhejiang University School of Medicine , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"2025020406194631100_r1","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/s41590-018-0256-2","article-title":"The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis","volume":"19","author":"Dainichi","year":"2018","journal-title":"Nat. Immunol."},{"key":"2025020406194631100_r2","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.cell.2016.10.052","article-title":"Impaired epidermal to dendritic T cell signaling slows wound repair in aged skin","volume":"167","author":"Keyes","year":"2016","journal-title":"Cell"},{"key":"2025020406194631100_r3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.it.2020.11.001","article-title":"Tolerogenic dendritic cells in autoimmunity and inflammatory diseases","volume":"42","author":"Morante-Palacios","year":"2021","journal-title":"Trends Immunol."},{"key":"2025020406194631100_r4","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nri3707","article-title":"The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing","volume":"14","author":"Gaffen","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"2025020406194631100_r5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/1346-8138.15184","article-title":"Dendritic cells: the driver of psoriasis","volume":"47","author":"Wang","year":"2020","journal-title":"J. Dermatol."},{"key":"2025020406194631100_r6","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/s41423-022-00940-8","article-title":"The epidermal immune microenvironment plays a dominant role in psoriasis development, as revealed by mass cytometry","volume":"19","author":"Zhou","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"2025020406194631100_r7","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.jaci.2019.10.041","article-title":"Short-term transcriptional response to IL-17 receptor-A antagonism in the treatment of psoriasis","volume":"145","author":"Tomalin","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025020406194631100_r8","doi-asserted-by":"crossref","first-page":"e12946","DOI":"10.1111\/sji.12946","article-title":"The TNF\/IL-23\/IL-17 axis \u2014head-to-head trials comparing different biologics in psoriasis treatment","volume":"92","author":"Ten Bergen","year":"2020","journal-title":"Scand. J. Immunol."},{"key":"2025020406194631100_r9","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.2147\/DDDT.S137588","article-title":"Evaluating guselkumab: an anti-IL-23 antibody for the treatment of plaque psoriasis","volume":"13","author":"Yang","year":"2019","journal-title":"Drug Des. Devel. Ther."},{"key":"2025020406194631100_r10","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.jid.2016.11.033","article-title":"Dynamic changes in resident and infiltrating epidermal dendritic cells in active and resolved psoriasis","volume":"137","author":"Martini","year":"2017","journal-title":"J. Invest. Dermatol."},{"key":"2025020406194631100_r11","doi-asserted-by":"crossref","first-page":"147413","DOI":"10.1155\/2012\/147413","article-title":"Ustekinumab in psoriasis immunopathology with emphasis on the Th17-IL23 axis: a primer","volume":"2012","author":"Quatresooz","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"2025020406194631100_r12","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41584-022-00778-4","article-title":"Disorders of ubiquitylation: unchained inflammation","volume":"18","author":"Beck","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"2025020406194631100_r13","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41580-021-00448-5","article-title":"Ubiquitin ligases: guardians of mammalian development","volume":"23","author":"Cruz Walma","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2025020406194631100_r14","doi-asserted-by":"crossref","first-page":"e52063","DOI":"10.15252\/embr.202052063","article-title":"E3 ubiquitin ligase NEDD4L negatively regulates keratinocyte hyperplasia by promoting GP130 degradation","volume":"22","author":"Liu","year":"2021","journal-title":"EMBO Rep."},{"key":"2025020406194631100_r15","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1084\/jem.20180210","article-title":"CRL4DCAF2 negatively regulates IL-23 production in dendritic cells and limits the development of psoriasis","volume":"215","author":"Huang","year":"2018","journal-title":"J. Exp. Med."},{"key":"2025020406194631100_r16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12943-018-0857-2","article-title":"FBXW7: a critical tumor suppressor of human cancers","volume":"17","author":"Yeh","year":"2018","journal-title":"Mol. Cancer"},{"key":"2025020406194631100_r17","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ccell.2014.09.013","article-title":"Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities","volume":"26","author":"Davis","year":"2014","journal-title":"Cancer Cell"},{"key":"2025020406194631100_r18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12943-022-01548-2","article-title":"Clinical significance of FBXW7 loss of function in human cancers","volume":"21","author":"Fan","year":"2022","journal-title":"Mol. Cancer"},{"key":"2025020406194631100_r19","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1172\/JCI123374","article-title":"Fbxw7 increases CCL2\/7 in CX3CR1hi macrophages to promote intestinal inflammation","volume":"129","author":"He","year":"2019","journal-title":"J. Clin. Invest."},{"key":"2025020406194631100_r20","doi-asserted-by":"crossref","first-page":"14654","DOI":"10.1038\/ncomms14654","article-title":"E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses","volume":"8","author":"Song","year":"2017","journal-title":"Nat. Commun."},{"key":"2025020406194631100_r21","doi-asserted-by":"crossref","first-page":"9294","DOI":"10.3390\/ijms22179294","article-title":"The role of epigenetic factors in psoriasis","volume":"22","author":"Dopytalska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2025020406194631100_r22","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/j.jisp.2018.09.007","article-title":"The aberrant epigenetic modifications in the pathogenesis of psoriasis","volume":"19","author":"Zhao","year":"2018","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"2025020406194631100_r23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jaut.2016.12.002","article-title":"Epigenetics of psoriatic disease: a systematic review and critical appraisal","volume":"78","author":"Pollock","year":"2017","journal-title":"J. Autoimmun."},{"key":"2025020406194631100_r24","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s41586-018-0398-2","article-title":"Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability","volume":"560","author":"Iglesias","year":"2018","journal-title":"Nature"},{"key":"2025020406194631100_r25","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0092-8674(01)00542-6","article-title":"Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability","volume":"107","author":"Peters","year":"2001","journal-title":"Cell"},{"key":"2025020406194631100_r26","doi-asserted-by":"crossref","first-page":"721","DOI":"10.7150\/jca.28254","article-title":"The oncogenic potential of SUV39H2: a comprehensive and perspective view","volume":"10","author":"Li","year":"2019","journal-title":"J. Cancer"},{"key":"2025020406194631100_r27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/15592294.2017.1281502","article-title":"A drive in SUVs: from development to disease","volume":"12","author":"Rao","year":"2017","journal-title":"Epigenetics"},{"key":"2025020406194631100_r28","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.2337\/db11-0073","article-title":"Genetic examination of SETD7 and SUV39H1\/H2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes","volume":"60","author":"Syreeni","year":"2011","journal-title":"Diabetes"},{"key":"2025020406194631100_r29","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1002\/hep.29127","article-title":"The histone methyltransferase Suv39h2 contributes to nonalcoholic steatohepatitis in mice","volume":"65","author":"Fan","year":"2017","journal-title":"Hepatology"},{"key":"2025020406194631100_r30","doi-asserted-by":"crossref","first-page":"6596","DOI":"10.4049\/jimmunol.179.10.6596","article-title":"A proximal \u03baB site in the IL-23 p19 promoter is responsible for RelA- and c-Rel-dependent transcription","volume":"179","author":"Mise-Omata","year":"2007","journal-title":"J. Immunol."},{"key":"2025020406194631100_r31","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4049\/jimmunol.178.1.186","article-title":"Essential roles of c-Rel in TLR-induced IL-23 p19 gene expression in dendritic cells","volume":"178","author":"Carmody","year":"2007","journal-title":"J. Immunol."},{"key":"2025020406194631100_r32","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nrc2290","article-title":"FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation","volume":"8","author":"Welcker","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"2025020406194631100_r33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semcancer.2020.02.017","article-title":"Recent insight into the role of FBXW7 as a tumor suppressor","volume":"67","author":"Yumimoto","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"2025020406194631100_r34","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.4049\/jimmunol.1800013","article-title":"Discovery of the IL-23\/IL-17 signaling pathway and the treatment of psoriasis","volume":"201","author":"Hawkes","year":"2018","journal-title":"J. Immunol."},{"key":"2025020406194631100_r35","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/ni.3347","article-title":"Epigenetic regulation of the expression of Il12 and Il23 and autoimmune inflammation by the deubiquitinase Trabid","volume":"17","author":"Jin","year":"2016","journal-title":"Nat. Immunol."},{"key":"2025020406194631100_r36","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1038\/s41467-018-03704-z","article-title":"Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation","volume":"9","author":"Li","year":"2018","journal-title":"Nat. Commun."},{"key":"2025020406194631100_r37","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.cell.2012.09.045","article-title":"Facilitators and impediments of the pluripotency reprogramming factors\u2019 initial engagement with the genome","volume":"151","author":"Soufi","year":"2012","journal-title":"Cell"},{"key":"2025020406194631100_r38","first-page":"4117","article-title":"Mechanism suppressing H3K9 trimethylation in pluripotent stem cells and its demise by polyQ-expanded huntingtin mutations","volume":"27","author":"Irmak","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"2025020406194631100_r39","doi-asserted-by":"crossref","first-page":"46667","DOI":"10.1038\/srep46667","article-title":"SUV39H1 reduction is implicated in abnormal inflammation in COPD. [Published erratum appears in 2017 Sci. Rep. 7: 46924.]","volume":"7","author":"Chen","year":"2017","journal-title":"Sci. Rep."},{"key":"2025020406194631100_r40","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/ni.3046","article-title":"The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection","volume":"16","author":"Schliehe","year":"2015","journal-title":"Nat. Immunol."},{"key":"2025020406194631100_r41","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature25167","article-title":"Senescence-associated reprogramming promotes cancer stemness","volume":"553","author":"Milanovic","year":"2018","journal-title":"Nature"},{"key":"2025020406194631100_r42","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1038\/ncomms2677","article-title":"FBXW7\u03b1 attenuates inflammatory signalling by downregulating C\/EBP\u03b4 and its target gene Tlr4","volume":"4","author":"Balamurugan","year":"2013","journal-title":"Nat. Commun."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/211\/11\/1701\/61472881\/ji2300023.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/211\/11\/1701\/61472881\/ji2300023.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T06:20:03Z","timestamp":1738650003000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/211\/11\/1701\/7925058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,16]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,12,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2300023","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,12]]},"published":{"date-parts":[[2023,10,16]]}}}