{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:48:22Z","timestamp":1789494502358,"version":"build-2803163510"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100012051","name":"Lupus Research Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R37 AR40072"],"award-info":[{"award-number":["R37 AR40072"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR074545"],"award-info":[{"award-number":["R01 AR074545"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["K01 AR067892"],"award-info":[{"award-number":["K01 AR067892"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR073912"],"award-info":[{"award-number":["R01 AR073912"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tbet+CD11c+ B cells, also known as age-associated B cells (ABCs), are pivotal contributors to humoral immunity following infection and in autoimmunity, yet their in\u00a0vivo generation is incompletely understood. We used a mouse model of systemic acute lymphocytic choriomeningitis virus infection to examine the developmental requirements of ABCs that emerged in the spleen and liver. IL-21 signaling through STAT3 was indispensable for ABC development. In contrast, IFN-\u03b3 signaling through STAT1 was required for B cell activation and proliferation. Mice that underwent splenectomy or were deficient in lymphotoxin \u03b1 generated hepatic ABCs despite the lack of secondary lymphoid organ contributions, suggesting that the liver supported de novo generation of these cells separately from their development in lymphoid organs. Thus, IFN-\u03b3 and IL-21 signaling have distinct, stage-specific roles in ABC differentiation, while the tissue microenvironment provides additional cues necessary for their development.<\/jats:p>","DOI":"10.4049\/jimmunol.2300027","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T13:33:21Z","timestamp":1683120801000},"page":"1861-1865","source":"Crossref","is-referenced-by-count":18,"title":["Cutting Edge: IL-21 and Tissue-Specific Signals Instruct Tbet+CD11c+ B Cell Development following Viral Infection"],"prefix":"10.1093","volume":"210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6969-7019","authenticated-orcid":false,"given":"Wenzhi","family":"Song","sequence":"first","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine , New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7807-1069","authenticated-orcid":false,"given":"Gina M","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Center for Immunity and Inflammation, Rutgers New Jersey Medical School , Newark, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P","family":"Mayer","sequence":"additional","affiliation":[{"name":"Center for Immunity and Inflammation, Rutgers New Jersey Medical School , Newark, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2759-3216","authenticated-orcid":false,"given":"Holly N","family":"Blackburn","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine , New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3346-0559","authenticated-orcid":false,"given":"Irene","family":"Chernova","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine , New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4461-0778","authenticated-orcid":false,"given":"Richard A","family":"Flavell","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine , New Haven, CT"},{"name":"Howard Hughes Medical Institute, Yale University School of Medicine , New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason S","family":"Weinstein","sequence":"additional","affiliation":[{"name":"Center for Immunity and Inflammation, Rutgers New Jersey Medical School , Newark, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1368-6756","authenticated-orcid":false,"given":"Joe","family":"Craft","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine , New Haven, CT"},{"name":"Department of Internal Medicine, Yale University School of Medicine , New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"key":"2025021008065917300_r1","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1182\/blood-2011-01-330530","article-title":"A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice","volume":"118","author":"Hao","year":"2011","journal-title":"Blood"},{"key":"2025021008065917300_r2","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1182\/blood-2011-01-331462","article-title":"Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity","volume":"118","author":"Rubtsov","year":"2011","journal-title":"Blood"},{"key":"2025021008065917300_r3","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1084\/jem.20072683","article-title":"Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals","volume":"205","author":"Moir","year":"2008","journal-title":"J. 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