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Craniotomy infection is characterized by complex spatial and temporal dynamics of leukocyte recruitment and microglial activation. We recently identified unique transcriptional profiles of these immune populations during S. aureus craniotomy infection. Epigenetic processes allow rapid and reversible control over gene transcription; however, little is known about how epigenetic pathways influence immunity to live S. aureus. An epigenetic compound library screen identified bromodomain and extraterminal domain\u2013containing (BET) proteins and histone deacetylases (HDACs) as critical for regulating TNF, IL-6, IL-10, and CCL2 production by primary mouse microglia, macrophages, neutrophils, and granulocytic myeloid-derived suppressor cells in response to live S. aureus. Class I HDACs (c1HDACs) were increased in these cell types in vitro and in vivo during acute disease in a mouse model of S. aureus craniotomy infection. However, substantial reductions in c1HDACs were observed during chronic infection, highlighting temporal regulation and the importance of the tissue microenvironment for dictating c1HDAC expression. Microparticle delivery of HDAC and BET inhibitors in vivo caused widespread decreases in inflammatory mediator production, which significantly increased bacterial burden in the brain, galea, and bone flap. These findings identify histone acetylation as an important mechanism for regulating cytokine and chemokine production across diverse immune cell lineages that is critical for bacterial containment. Accordingly, aberrant epigenetic regulation may be important for promoting S. aureus persistence during craniotomy infection.<\/jats:p>","DOI":"10.4049\/jimmunol.2300050","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T14:56:11Z","timestamp":1686754571000},"page":"414-428","source":"Crossref","is-referenced-by-count":13,"title":["Epigenetic Regulation of Leukocyte Inflammatory Mediator Production Dictates <i>Staphylococcus aureus<\/i> Craniotomy Infection Outcome"],"prefix":"10.1093","volume":"211","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6015-8411","authenticated-orcid":false,"given":"Zachary","family":"Van Roy","sequence":"first","affiliation":[{"name":"Department of Pathology and Microbiology, University of Nebraska Medical Center , Omaha, NE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Shi","sequence":"additional","affiliation":[{"name":"Mary and Dick Holland Regenerative Medicine Program, Division of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center , Omaha, NE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunjan","family":"Kak","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, University of Nebraska Medical Center , Omaha, NE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5647-3793","authenticated-orcid":false,"given":"Bin","family":"Duan","sequence":"additional","affiliation":[{"name":"Mary and Dick Holland Regenerative Medicine Program, Division of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center , Omaha, NE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7624-670X","authenticated-orcid":false,"given":"Tammy","family":"Kielian","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, University of Nebraska Medical Center , Omaha, NE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,8,1]]},"reference":[{"key":"2025020406041394200_r1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1128\/CMR.00134-14","article-title":"Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management","volume":"28","author":"Tong","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"2025020406041394200_r2","first-page":"938","article-title":"Antibiotic resistance threats in the United States: stepping back from the brink","volume":"89","author":"Solomon","year":"2014","journal-title":"Am. Fam. Physician"},{"key":"2025020406041394200_r3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/21505594.2021.1878688","article-title":"Pathogenicity and virulence of Staphylococcus aureus","volume":"12","author":"Cheung","year":"2021","journal-title":"Virulence"},{"key":"2025020406041394200_r4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.meegid.2008.09.012","article-title":"Co-evolutionary aspects of human colonisation and infection by Staphylococcus aureus","volume":"9","author":"van Belkum","year":"2009","journal-title":"Infect. Genet. 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Wound J."},{"key":"2025020406041394200_r34","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neulet.2010.03.013","article-title":"NOD2 contributes to the inflammatory responses of primary murine microglia and astrocytes to Staphylococcus aureus","volume":"474","author":"Liu","year":"2010","journal-title":"Neurosci. Lett."},{"key":"2025020406041394200_r35","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/glia.21243","article-title":"Toll-like receptor 2 (TLR2)-TLR9 crosstalk dictates IL-12 family cytokine production in microglia","volume":"60","author":"Holley","year":"2012","journal-title":"Glia"},{"key":"2025020406041394200_r36","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1471-4159.2011.07481.x","article-title":"Inflammasome activation and IL-1\u03b2\/IL-18 processing are influenced by distinct pathways in microglia","volume":"119","author":"Hanamsagar","year":"2011","journal-title":"J. Neurochem."},{"key":"2025020406041394200_r37","doi-asserted-by":"crossref","first-page":"6802","DOI":"10.4049\/jimmunol.176.11.6802","article-title":"Central role for MyD88 in the responses of microglia to pathogen-associated molecular patterns","volume":"176","author":"Esen","year":"2006","journal-title":"J. Immunol."},{"key":"2025020406041394200_r38","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1006\/excr.1998.4027","article-title":"FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor","volume":"241","author":"Nakajima","year":"1998","journal-title":"Exp. Cell Res."},{"key":"2025020406041394200_r39","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/nature09504","article-title":"Selective inhibition of BET bromodomains","volume":"468","author":"Filippakopoulos","year":"2010","journal-title":"Nature"},{"key":"2025020406041394200_r40","doi-asserted-by":"crossref","first-page":"35402","DOI":"10.1074\/jbc.M807045200","article-title":"Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases","volume":"283","author":"Chou","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2025020406041394200_r41","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1073\/pnas.1213364110","article-title":"HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner","volume":"110","author":"Malvaez","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025020406041394200_r42","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.tips.2016.12.006","article-title":"Targeting class I histone deacetylases in a \u201ccomplex\u201d environment","volume":"38","author":"Millard","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"key":"2025020406041394200_r43","doi-asserted-by":"crossref","first-page":"8113","DOI":"10.1073\/pnas.0610226104","article-title":"The cidA murein hydrolase regulator contributes to DNA release and biofilm development in Staphylococcus aureus","volume":"104","author":"Rice","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025020406041394200_r44","doi-asserted-by":"crossref","first-page":"e1002744","DOI":"10.1371\/journal.ppat.1002744","article-title":"Functional amyloids composed of phenol soluble modulins stabilize Staphylococcus aureus biofilms","volume":"8","author":"Schwartz","year":"2012","journal-title":"PLoS Pathog."},{"key":"2025020406041394200_r45","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/j.biomaterials.2006.11.046","article-title":"Polysaccharide intercellular adhesin or protein factors in biofilm accumulation of Staphylococcus epidermidis and Staphylococcus aureus isolated from prosthetic hip and knee joint infections","volume":"28","author":"Rohde","year":"2007","journal-title":"Biomaterials"},{"key":"2025020406041394200_r46","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1021\/np200324x","article-title":"Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities","volume":"74","author":"Wang","year":"2011","journal-title":"J. Nat. Prod."},{"key":"2025020406041394200_r47","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1016\/j.bmcl.2008.04.007","article-title":"Development of a fluorescence polarization based assay for histone deacetylase ligand discovery","volume":"18","author":"Mazitschek","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"2025020406041394200_r48","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1084\/jem.20180520","article-title":"HDAC stimulates gene expression through BRD4 availability in response to IFN and in interferonopathies","volume":"215","author":"Mari\u00e9","year":"2018","journal-title":"J. Exp. Med."},{"key":"2025020406041394200_r49","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.bbrc.2018.02.096","article-title":"Selective degradation of BET proteins with dBET1, a proteolysis-targeting chimera, potently reduces pro-inflammatory responses in lipopolysaccharide-activated microglia","volume":"497","author":"DeMars","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025020406041394200_r50","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1007\/s11064-015-1710-2","article-title":"The epigenetic reader BRD2 as a specific modulator of PAI-1 expression in lipopolysaccharide-stimulated mouse primary astrocytes","volume":"40","author":"Choi","year":"2015","journal-title":"Neurochem. Res."},{"key":"2025020406041394200_r51","doi-asserted-by":"crossref","first-page":"e20202512","DOI":"10.1084\/jem.20202512","article-title":"Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection","volume":"218","author":"Milner","year":"2021","journal-title":"J. Exp. Med."},{"key":"2025020406041394200_r52","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1073\/pnas.052702999","article-title":"The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines","volume":"99","author":"Leoni","year":"2002","journal-title":"Proc. Natl. Acad. Sci. 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Redox Signal."},{"key":"2025020406041394200_r58","doi-asserted-by":"crossref","first-page":"696","DOI":"10.3389\/fimmu.2016.00696","article-title":"Epigenetic regulation of interleukin 6 by histone acetylation in macrophages and its role in paraquat-induced pulmonary fibrosis","volume":"7","author":"Hu","year":"2017","journal-title":"Front. Immunol."},{"key":"2025020406041394200_r59","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.1128\/MCB.02429-06","article-title":"Epigenetic regulation of tumor necrosis factor alpha","volume":"27","author":"Sullivan","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"2025020406041394200_r60","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.3390\/ijms20071601","article-title":"apoptosis induction by histone deacetylase inhibitors in cancer cells: role of Ku70","volume":"20","author":"Gong","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2025020406041394200_r61","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/sj.cdd.4401567","article-title":"Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1\/WAF1 expression, independent of histone deacetylase 1","volume":"12","author":"Huang","year":"2005","journal-title":"Cell Death Differ."},{"key":"2025020406041394200_r62","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1007\/s00018-014-1656-6","article-title":"Histone deacetylase inhibitors and cell death","volume":"71","author":"Zhang","year":"2014","journal-title":"Cell. Mol. 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