{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:16:19Z","timestamp":1779084979072,"version":"3.51.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN 154332"],"award-info":[{"award-number":["FDN 154332"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["1P01AI102853-01"],"award-info":[{"award-number":["1P01AI102853-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023363","name":"Praespero","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Recent thymic emigrant (RTE) cells are nascent T cells that continue their post-thymic maturation in the periphery and dominate T cell immune responses in early life and in adults having undergone lymphodepletion regimens. However, the events that govern their maturation and their functionality as they transition to mature naive T cells have not been clearly defined. Using RBPJind mice, we were able to identify different stages of RTE maturation and interrogate their immune function using a T cell transfer model of colitis. As CD45RBlo RTE cells mature, they transition through a CD45RBint immature naive T (INT) cell population that is more immunocompetent but shows a bias toward IL-17 production at the expense of IFN-\u03b3. Additionally, the levels of IFN-\u03b3 and IL-17 produced in INT cells are highly dependent on whether Notch signals are received during INT cell maturation or during their effector function. IL-17 production by INT cells showed a total requirement for Notch signaling. Loss of Notch signaling at any stage of INT cells resulted in an impaired colitogenic effect of INT cells. RNA sequencing of INT cells that had matured in the absence of Notch signals showed a reduced inflammatory profile compared with Notch-responsive INT cells. Overall, we have elucidated a previously unknown INT cell stage, revealed its intrinsic bias toward IL-17 production, and demonstrated a role for Notch signaling in INT cell peripheral maturation and effector function in the context of a T cell transfer model of colitis.<\/jats:p>","DOI":"10.4049\/jimmunol.2300140","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T14:03:03Z","timestamp":1683554583000},"page":"81-90","source":"Crossref","is-referenced-by-count":4,"title":["Recent Thymic Emigrants Require RBPJ-Dependent Notch Signaling to Transition into Functionally Mature Naive T Cells"],"prefix":"10.1093","volume":"211","author":[{"given":"Sintia","family":"Teichman","sequence":"first","affiliation":[{"name":"Biological Sciences, Sunnybrook Research Institute , Toronto, ON ,","place":["Canada"]},{"name":"Department of Immunology, University of Toronto , Toronto, ON ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Wang","sequence":"additional","affiliation":[{"name":"Biological Sciences, Sunnybrook Research Institute , Toronto, ON ,","place":["Canada"]},{"name":"Department of Immunology, University of Toronto , Toronto, ON ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina R","family":"Lee","sequence":"additional","affiliation":[{"name":"Biological Sciences, Sunnybrook Research Institute , Toronto, ON ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmood","family":"Mohtashami","sequence":"additional","affiliation":[{"name":"Biological Sciences, Sunnybrook Research Institute , Toronto, ON ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3271-0782","authenticated-orcid":false,"given":"Elisabeth","family":"Foerster","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Toronto , Toronto, ON ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2695-5297","authenticated-orcid":false,"given":"Jianxun","family":"Han","sequence":"additional","affiliation":[{"name":"Biological Sciences, Sunnybrook Research Institute , Toronto, ON ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashton C","family":"Trotman-Grant","sequence":"additional","affiliation":[{"name":"Biological Sciences, Sunnybrook Research Institute , Toronto, ON ,","place":["Canada"]},{"name":"Department of Immunology, University of Toronto , Toronto, ON ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawn","family":"Winer","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto , Toronto, ON ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert","family":"Tsui","sequence":"additional","affiliation":[{"name":"Biological Sciences, Sunnybrook Research Institute , Toronto, ON ,","place":["Canada"]},{"name":"Department of Immunology, University of Toronto , Toronto, ON ,","place":["Canada"]},{"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto , Toronto, ON ,","place":["Canada"]},{"name":"Division of Hematological Pathology, Department of Laboratory Medicine and Molecular Diagnostics, Precision Diagnostics and Therapeutics Program, Sunnybrook Health Sciences Centre , Toronto, ON ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana J","family":"Philpott","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Toronto , Toronto, ON ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2538-3178","authenticated-orcid":false,"given":"Juan Carlos","family":"Z\u00fa\u00f1iga-Pfl\u00fccker","sequence":"additional","affiliation":[{"name":"Biological Sciences, Sunnybrook Research Institute , Toronto, ON ,","place":["Canada"]},{"name":"Department of Immunology, University of Toronto , Toronto, ON ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,8]]},"reference":[{"key":"2025020405591111200_r1","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1182\/blood.V97.5.1360","article-title":"Thymic emigrants isolated by a new method possess unique phenotypic and functional properties","volume":"97","author":"Lee","year":"2001","journal-title":"Blood"},{"key":"2025020405591111200_r2","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.1073\/pnas.0812354106","article-title":"Postthymic maturation influences the CD8 T cell response to antigen","volume":"106","author":"Makaroff","year":"2009","journal-title":"Proc. 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