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We have found that 4-OI significantly reduces the production of eosinophil-targeted chemokines in a variety of cell types, including M1 and M2 macrophages, Th2 cells, and A549 respiratory epithelial cells. Notably, the suppression of these chemokines in M1 macrophages was found to be NRF2-dependent. In addition, 4-OI can interfere with IL-5 signaling and directly affect eosinophil differentiation. In a model of eosinophilic airway inflammation in BALB\/c mice, 4-OI alleviated airway resistance and reduced eosinophil recruitment to the lungs. Our findings suggest that itaconate derivatives could be promising therapeutic agents for the treatment of eosinophilic asthma.<\/jats:p>","DOI":"10.4049\/jimmunol.2300155","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T09:47:28Z","timestamp":1700646448000},"page":"13-23","source":"Crossref","is-referenced-by-count":18,"title":["4-Octyl Itaconate Alleviates Airway Eosinophilic Inflammation by Suppressing Chemokines and Eosinophil Development"],"prefix":"10.1093","volume":"212","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1451-9906","authenticated-orcid":false,"given":"Maureen","family":"Yin","sequence":"first","affiliation":[{"name":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin , Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8074-1543","authenticated-orcid":false,"given":"Ridhima","family":"Wadhwa","sequence":"additional","affiliation":[{"name":"Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences , Sydney, New South Wales ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3263-3297","authenticated-orcid":false,"given":"Jacqueline E","family":"Marshall","sequence":"additional","affiliation":[{"name":"Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences , Sydney, New South Wales ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin M","family":"Gillis","sequence":"additional","affiliation":[{"name":"Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences , Sydney, New South Wales ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Y","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Faculty of Science, University of Technology Sydney , Sydney, New South Wales ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7507-1159","authenticated-orcid":false,"given":"Kamal","family":"Dua","sequence":"additional","affiliation":[{"name":"Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences , Sydney, New South Wales ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0201-5171","authenticated-orcid":false,"given":"Eva M","family":"Palsson-McDermott","sequence":"additional","affiliation":[{"name":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin , Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8401-7293","authenticated-orcid":false,"given":"Padraic G","family":"Fallon","sequence":"additional","affiliation":[{"name":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin , Dublin ,","place":["Ireland"]},{"name":"School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin , Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4741-3035","authenticated-orcid":false,"given":"Philip M","family":"Hansbro","sequence":"additional","affiliation":[{"name":"Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences , Sydney, New South Wales ,","place":["Australia"]},{"name":"Priority Research Centre for Immune Health, Hunter Medical Research Institute and University of Newcastle , Newcastle, New South Wales ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke A J","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin , Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"2025020405424932500_r1","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1111\/all.14607","article-title":"Advances and recent developments in asthma in 2020","volume":"75","author":"Cevhertas","year":"2020","journal-title":"Allergy"},{"key":"2025020405424932500_r2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1164\/rccm.201611-2232PP","article-title":"Eosinophilic and noneosinophilic asthma","volume":"197","author":"Carr","year":"2018","journal-title":"Am. 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