{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:51:04Z","timestamp":1789480264819,"version":"build-2803163510"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100002879","name":"Canadian HIV Trials Network, Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CIHR PJT-180271"],"award-info":[{"award-number":["CIHR PJT-180271"]}],"id":[{"id":"10.13039\/501100002879","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Vitamin D deficiency is associated with the development of autoimmunity, which arises from defects in T cell tolerance to self-antigens. Interactions of developing T cells with medullary thymic epithelial cells, which express tissue-restricted Ags, are essential for the establishment of central tolerance. However, vitamin D signaling in the thymus is poorly characterized. We find that stromal and hematopoietic cells in the mouse thymus express the vitamin D receptor (Vdr) and Cyp27b1, the enzyme that produces hormonal 1,25-dihydroxyvitamin D (1,25D). Treatment of cultured thymic slices with 1,25D enhances expression of the critical medullary thymic epithelial cell transcription factor autoimmune regulator (Aire), its colocalization with the Vdr, and enhances tissue-restricted Ag gene expression. Moreover, the Vdr interacts with Aire in a 1,25D-dependent manner and recruits Aire to DNA at vitamin D response elements, where it acts as a Vdr coactivator. These data link vitamin D signaling directly to critical transcriptional events necessary for central tolerance.<\/jats:p>","DOI":"10.4049\/jimmunol.2300207","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T13:48:11Z","timestamp":1685713691000},"page":"175-179","source":"Crossref","is-referenced-by-count":6,"title":["Cutting Edge: Aire Is a Coactivator of the Vitamin D Receptor"],"prefix":"10.1093","volume":"211","author":[{"given":"Patricio","family":"Artusa","sequence":"first","affiliation":[{"name":"Department of Physiology, McGill University , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-\u00c8ve","family":"Lebel","sequence":"additional","affiliation":[{"name":"Maisonneuve-Rosemont Hospital Research Center , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Barbier","sequence":"additional","affiliation":[{"name":"Department of Physiology, McGill University , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4754-6217","authenticated-orcid":false,"given":"Babak","family":"Memari","sequence":"additional","affiliation":[{"name":"Department of Physiology, McGill University , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9111-6513","authenticated-orcid":false,"given":"Reyhaneh","family":"Salehi-Tabar","sequence":"additional","affiliation":[{"name":"Department of Physiology, McGill University , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5695-9728","authenticated-orcid":false,"given":"Sophia","family":"Karabatsos","sequence":"additional","affiliation":[{"name":"Department of Physiology, McGill University , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5530-5336","authenticated-orcid":false,"given":"Aiten","family":"Ismailova","sequence":"additional","affiliation":[{"name":"Department of Physiology, McGill University , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0951-334X","authenticated-orcid":false,"given":"Heather J","family":"Melichar","sequence":"additional","affiliation":[{"name":"Maisonneuve-Rosemont Hospital Research Center , Montreal, Quebec ,","place":["Canada"]},{"name":"D\u00e9partement de M\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4785-2687","authenticated-orcid":false,"given":"John H","family":"White","sequence":"additional","affiliation":[{"name":"Department of Physiology, McGill University , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"key":"2025020406012746600_r1","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1210\/er.2018-00126","article-title":"Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions","volume":"40","author":"Bouillon","year":"2019","journal-title":"Endocr. 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