{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:42:19Z","timestamp":1791513739575,"version":"4.3.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273088"],"award-info":[{"award-number":["82273088"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872239"],"award-info":[{"award-number":["81872239"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971879"],"award-info":[{"award-number":["81971879"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"\u5929\u6d25\u5e02\u79d1\u5b66\u6280\u672f\u5c40 | Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["20JCYBJC00220"],"award-info":[{"award-number":["20JCYBJC00220"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The one-carbon metabolism enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is critical for cancer cell proliferation and immune cell phenotypes, but whether it can contribute to macrophage inflammatory responses remains unclear. In this study, we show that MTHFD2 was upregulated by LPS in murine macrophages upon activation of the TLR4\u2013MyD88\u2013IKK\u03b1\/\u03b2\u2013NF-\u03baB signaling pathway. MTHFD2 significantly attenuated LPS-induced macrophage proinflammatory cytokine production through its enzymatic activity. Notably, ablation of myeloid MTHFD2 rendered mice more sensitive to septic shock and CCl4-induced acute hepatitis. Mechanistically, MTHFD2 restrained IKK\u03b1\/\u03b2\u2013NF-\u03baB activation and macrophage inflammatory phenotype by scavenging reactive oxygen species through the generation of NADPH. Our study reveals MTHFD2 as a \u201cself-control\u201d mechanism in macrophage-mediated inflammatory responses.<\/jats:p>","DOI":"10.4049\/jimmunol.2300209","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T14:09:54Z","timestamp":1708956594000},"page":"1345-1356","source":"Crossref","is-referenced-by-count":16,"title":["Induction of MTHFD2 in Macrophages Inhibits Reactive Oxygen Species\u2013mediated NF-\u03baB Activation and Protects against Inflammatory Responses"],"prefix":"10.1093","volume":"212","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9443-8991","authenticated-orcid":false,"given":"Yan","family":"Cui","sequence":"first","affiliation":[{"name":"Tianjin Institute of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, Tianjin Medical University , Tianjin ,","place":["China"]},{"name":"Department of Critical Care Medicine, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]},{"name":"Department of Anesthesiology, Tianjin Institute of Anesthesiology, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]},{"name":"Department of Health Management Center & Institute of Health Management, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, Tianjin Medical University , Tianjin ,","place":["China"]},{"name":"Department of Critical Care Medicine, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]},{"name":"Department of Anesthesiology, Tianjin Institute of Anesthesiology, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Ni","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, Tianjin Medical University , Tianjin ,","place":["China"]},{"name":"Department of Critical Care Medicine, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]},{"name":"Department of Anesthesiology, Tianjin Institute of Anesthesiology, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujun","family":"Yu","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, Tianjin Medical University , Tianjin ,","place":["China"]},{"name":"Department of Critical Care Medicine, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]},{"name":"Department of Anesthesiology, Tianjin Institute of Anesthesiology, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Shan","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, Tianjin Medical University , Tianjin ,","place":["China"]},{"name":"Department of Critical Care Medicine, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]},{"name":"Department of Anesthesiology, Tianjin Institute of Anesthesiology, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penghui","family":"Hu","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, Tianjin Medical University , Tianjin ,","place":["China"]},{"name":"Department of Critical Care Medicine, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]},{"name":"Department of Anesthesiology, Tianjin Institute of Anesthesiology, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zemin","family":"Ji","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, Tianjin Medical University , Tianjin ,","place":["China"]},{"name":"Department of Critical Care Medicine, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]},{"name":"Department of Anesthesiology, Tianjin Institute of Anesthesiology, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Jing","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, Tianjin Medical University , Tianjin ,","place":["China"]},{"name":"Department of Critical Care Medicine, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]},{"name":"Department of Anesthesiology, Tianjin Institute of Anesthesiology, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, Tianjin Medical University , Tianjin ,","place":["China"]},{"name":"Department of Critical Care Medicine, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]},{"name":"Department of Anesthesiology, Tianjin Institute of Anesthesiology, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baochen","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, Tianjin Medical University , Tianjin ,","place":["China"]},{"name":"Department of Critical Care Medicine, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]},{"name":"Department of Anesthesiology, Tianjin Institute of Anesthesiology, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyuan","family":"Dong","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, Tianjin Medical University , Tianjin ,","place":["China"]},{"name":"Department of Critical Care Medicine, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]},{"name":"Department of Anesthesiology, Tianjin Institute of Anesthesiology, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxue","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital , Zhengzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keliang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]},{"name":"Department of Anesthesiology, Tianjin Institute of Anesthesiology, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3978-643X","authenticated-orcid":false,"given":"Qiujing","family":"Yu","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, Tianjin Medical University , Tianjin ,","place":["China"]},{"name":"Department of Critical Care Medicine, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]},{"name":"Department of Anesthesiology, Tianjin Institute of Anesthesiology, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]},{"name":"Department of Health Management Center & Institute of Health Management, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"2025020405482990500_r1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature"},{"key":"2025020405482990500_r2","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J. Clin. Invest."},{"key":"2025020405482990500_r3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/ni.3306","article-title":"Molecular control of activation and priming in macrophages","volume":"17","author":"Glass","year":"2016","journal-title":"Nat. Immunol."},{"key":"2025020405482990500_r4","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/imm.12910","article-title":"Implications of macrophage polarization in autoimmunity","volume":"154","author":"Funes","year":"2018","journal-title":"Immunology"},{"key":"2025020405482990500_r5","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"2025020405482990500_r6","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cell.2016.08.064","article-title":"Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages","volume":"167","author":"Mills","year":"2016","journal-title":"Cell"},{"key":"2025020405482990500_r7","doi-asserted-by":"crossref","first-page":"14274","DOI":"10.1074\/jbc.M115.685792","article-title":"Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase to modulate intracellular succinate levels","volume":"291","author":"Cordes","year":"2016","journal-title":"J. Biol. Chem."},{"key":"2025020405482990500_r8","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cmet.2016.06.004","article-title":"Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation","volume":"24","author":"Lampropoulou","year":"2016","journal-title":"Cell Metab."},{"key":"2025020405482990500_r9","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.it.2012.05.002","article-title":"Dissecting negative regulation of Toll-like receptor signaling","volume":"33","author":"Kondo","year":"2012","journal-title":"Trends Immunol."},{"key":"2025020405482990500_r10","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.3389\/fimmu.2019.03112","article-title":"Macrophage phenotype and function in liver disorder","volume":"10","author":"Dou","year":"2019","journal-title":"Front. Immunol."},{"key":"2025020405482990500_r11","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1161\/CIRCRESAHA.119.315939","article-title":"Intracellular and intercellular aspects of macrophage immunometabolism in atherosclerosis","volume":"126","author":"Tabas","year":"2020","journal-title":"Circ. Res."},{"key":"2025020405482990500_r12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41556-018-0217-x","article-title":"Metabolism as a guiding force for immunity","volume":"21","author":"Jung","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"2025020405482990500_r13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1084\/jem.20151570","article-title":"Immunometabolism governs dendritic cell and macrophage function","volume":"213","author":"O\u2019Neill","year":"2016","journal-title":"J. Exp. Med."},{"key":"2025020405482990500_r14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/imr.12858","article-title":"Immunometabolism: from basic mechanisms to translation","volume":"295","author":"Makowski","year":"2020","journal-title":"Immunol. Rev."},{"key":"2025020405482990500_r15","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41590-018-0113-3","article-title":"Regulation of macrophage immunometabolism in atherosclerosis","volume":"19","author":"Koelwyn","year":"2018","journal-title":"Nat. Immunol."},{"key":"2025020405482990500_r16","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cmet.2012.04.023","article-title":"The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism","volume":"15","author":"Haschemi","year":"2012","journal-title":"Cell Metab."},{"key":"2025020405482990500_r17","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.immuni.2015.02.005","article-title":"Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization","volume":"42","author":"Jha","year":"2015","journal-title":"Immunity"},{"key":"2025020405482990500_r18","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nrc3557","article-title":"Serine, glycine and one-carbon units: cancer metabolism in full circle","volume":"13","author":"Locasale","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"2025020405482990500_r19","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/s41423-022-00925-7","article-title":"Serine metabolism orchestrates macrophage polarization by regulating the IGF1\u2013p38 axis","volume":"19","author":"Shan","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"2025020405482990500_r20","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/jnci\/djy160","article-title":"Modulation of redox homeostasis by inhibition of MTHFD2 in colorectal cancer: mechanisms and therapeutic implications","volume":"111","author":"Ju","year":"2019","journal-title":"J. Natl. Cancer Inst."},{"key":"2025020405482990500_r21","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41419-020-02825-y","article-title":"Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell","volume":"11","author":"Wan","year":"2020","journal-title":"Cell Death Dis."},{"key":"2025020405482990500_r22","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature13236","article-title":"Quantitative flux analysis reveals folate-dependent NADPH production","volume":"510","author":"Fan","year":"2014","journal-title":"Nature"},{"key":"2025020405482990500_r23","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.cmet.2019.06.003","article-title":"Epstein-Barr-virus-induced one-carbon metabolism drives B cell transformation","volume":"30","author":"Wang","year":"2019","journal-title":"Cell Metab."},{"key":"2025020405482990500_r24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.immuni.2021.10.011","article-title":"MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function","volume":"55","author":"Sugiura","year":"2021","journal-title":"Immunity."},{"key":"2025020405482990500_r25","doi-asserted-by":"crossref","first-page":"112481","DOI":"10.1016\/j.celrep.2023.112481","article-title":"MTHFD2 reprograms macrophage polarization by inhibiting PTEN","volume":"42","author":"Shang","year":"2023","journal-title":"Cell Rep."},{"key":"2025020405482990500_r26","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of reactive oxygen species and NF-\u03baB signaling","volume":"21","author":"Morgan","year":"2011","journal-title":"Cell Res."},{"key":"2025020405482990500_r27","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.freeradbiomed.2013.06.020","article-title":"Bidirectional regulation of NF-\u03baB by reactive oxygen species: a role of unfolded protein response","volume":"65","author":"Nakajima","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"2025020405482990500_r28","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.molcel.2019.06.039","article-title":"One-carbon metabolism supports S-adenosylmethionine and histone methylation to drive inflammatory macrophages","volume":"75","author":"Yu","year":"2019","journal-title":"Mol. Cell."},{"key":"2025020405482990500_r29","doi-asserted-by":"crossref","first-page":"7820","DOI":"10.1073\/pnas.1218599110","article-title":"Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production","volume":"110","author":"Michelucci","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025020405482990500_r30","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1515\/znc-2001-7-826","article-title":"Mechanism of carbon tetrachloride-induced hepatotoxicity. Hepatocellular damage by reactive carbon tetrachloride metabolites","volume":"56","author":"Boll","year":"2001","journal-title":"Z. Naturforsch. C J. Biosci."},{"key":"2025020405482990500_r31","article-title":"5-O-demethylnobiletin alleviates CCl4-induced acute liver injury by equilibrating ROS-mediated apoptosis and autophagy induction","volume":"22","author":"Chang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2025020405482990500_r32","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s11095-014-1483-3","article-title":"Protective effects of calycosin against CCl4-induced liver injury with activation of FXR and STAT3 in mice","volume":"32","author":"Chen","year":"2015","journal-title":"Pharm. Res."},{"key":"2025020405482990500_r33","doi-asserted-by":"crossref","first-page":"6605","DOI":"10.3748\/wjg.v18.i45.6605","article-title":"Hepatoprotective effects of baicalein against CCl4-induced acute liver injury in mice","volume":"18","author":"Huang","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"2025020405482990500_r34","doi-asserted-by":"crossref","first-page":"6211","DOI":"10.1038\/s41388-019-0869-4","article-title":"MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma","volume":"38","author":"Green","year":"2019","journal-title":"Oncogene"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/212\/8\/1345\/61474666\/ji2300209.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/212\/8\/1345\/61474666\/ji2300209.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T05:51:01Z","timestamp":1738648261000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/212\/8\/1345\/7926023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,26]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,4,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2300209","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,4]]},"published":{"date-parts":[[2024,2,26]]}}}