{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T03:31:47Z","timestamp":1752550307465,"version":"3.37.3"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100015691","name":"HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI138504"],"award-info":[{"award-number":["R01 AI138504"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA206517"],"award-info":[{"award-number":["R01 CA206517"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["T32 CA082084"],"award-info":[{"award-number":["T32 CA082084"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R03 AI131049"],"award-info":[{"award-number":["R03 AI131049"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tim-3 is a transmembrane protein that is best known for being highly expressed on terminally exhausted CD8+ T cells associated with chronic infection and tumors, although its expression is not limited to those settings. Tim-3 is also expressed by CD8+ T cells during acute infection and by multiple other immune cell types, including CD4+ Th1 and regulatory T cells, dendritic cells, and mast cells. In this study, we investigated the role of Tim-3 signaling on CD8+ T cell memory using a Tim-3 conditional knockout mouse model and mice lacking the signaling portion of the Tim-3 cytoplasmic domain. Together, our results indicate that Tim-3 has at most a modest effect on the formation and function of CD8+ memory T cells.<\/jats:p>","DOI":"10.4049\/jimmunol.2300401","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T14:12:42Z","timestamp":1702908762000},"page":"466-474","source":"Crossref","is-referenced-by-count":1,"title":["Tim-3 Is Not Required for Establishment of CD8+ T Cell Memory to Lymphocytic Choriomeningitis Virus"],"prefix":"10.1093","volume":"212","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2868-5286","authenticated-orcid":false,"given":"Priyanka","family":"Manandhar","sequence":"first","affiliation":[{"name":"Department of Immunology, University of Pittsburgh , Pittsburgh, PA"},{"name":"Graduate Program in Microbiology and Immunology, University of Pittsburgh , Pittsburgh, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9757-3432","authenticated-orcid":false,"given":"Andrea L","family":"Szymczak-Workman","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Pittsburgh , Pittsburgh, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5198-516X","authenticated-orcid":false,"given":"Lawrence P","family":"Kane","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Pittsburgh , Pittsburgh, PA"},{"name":"Graduate Program in Microbiology and Immunology, University of Pittsburgh , Pittsburgh, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,12,18]]},"reference":[{"key":"2025020405435978700_r1","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/ni1009","article-title":"Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells","volume":"4","author":"Kaech","year":"2003","journal-title":"Nat. Immunol."},{"key":"2025020405435978700_r2","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nri3307","article-title":"Transcriptional control of effector and memory CD8+ T cell differentiation","volume":"12","author":"Kaech","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"2025020405435978700_r3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nri2251","article-title":"Shaping and reshaping CD8+ T-cell memory","volume":"8","author":"Harty","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"2025020405435978700_r4","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.4049\/jimmunol.1201556","article-title":"Differential localization of T-bet and Eomes in CD8 T cell memory populations","volume":"190","author":"McLane","year":"2013","journal-title":"J. Immunol."},{"key":"2025020405435978700_r5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.it.2019.11.004","article-title":"Stem, effector, and hybrid states of memory CD8+ T cells","volume":"41","author":"Lugli","year":"2020","journal-title":"Trends Immunol."},{"key":"2025020405435978700_r6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.immuni.2007.07.010","article-title":"Inflammation directs memory precursor and short-lived effector CD8+ T cell fates via the graded expression of T-bet transcription factor","volume":"27","author":"Joshi","year":"2007","journal-title":"Immunity"},{"key":"2025020405435978700_r7","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1084\/jem.20071641","article-title":"Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates","volume":"205","author":"Sarkar","year":"2008","journal-title":"J. Exp. Med."},{"key":"2025020405435978700_r8","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nature25144","article-title":"Effector CD8 T cells dedifferentiate into long-lived memory cells","volume":"552","author":"Youngblood","year":"2017","journal-title":"Nature"},{"key":"2025020405435978700_r9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.imlet.2017.02.012","article-title":"Understanding memory CD8+ T cells","volume":"185","author":"Samji","year":"2017","journal-title":"Immunol. Lett."},{"key":"2025020405435978700_r10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1600-065X.2010.00926.x","article-title":"Generation of effector CD8+ T cells and their conversion to memory T cells","volume":"236","author":"Cui","year":"2010","journal-title":"Immunol. Rev."},{"key":"2025020405435978700_r11","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.4049\/jimmunol.180.3.1309","article-title":"Effector CD8 T cell development: a balancing act between memory cell potential and terminal differentiation","volume":"180","author":"Joshi","year":"2008","journal-title":"J. Immunol."},{"key":"2025020405435978700_r12","doi-asserted-by":"crossref","first-page":"5990","DOI":"10.4049\/jimmunol.181.9.5990","article-title":"OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells","volume":"181","author":"Mousavi","year":"2008","journal-title":"J. Immunol."},{"key":"2025020405435978700_r13","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/ni1268","article-title":"Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. [Published erratum appears in 2006 Nat. Immunol. 7: 113.]","volume":"6","author":"Intlekofer","year":"2005","journal-title":"Nat. Immunol."},{"key":"2025020405435978700_r14","doi-asserted-by":"crossref","first-page":"eabe3702","DOI":"10.1126\/sciimmunol.abe3702","article-title":"Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage","volume":"6","author":"Johnnidis","year":"2021","journal-title":"Sci. Immunol."},{"key":"2025020405435978700_r15","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.4049\/jimmunol.1502481","article-title":"IL-10 regulates memory T cell development and the balance between Th1 and follicular Th cell responses during an acute viral infection","volume":"197","author":"Tian","year":"2016","journal-title":"J. Immunol."},{"key":"2025020405435978700_r16","doi-asserted-by":"crossref","first-page":"107827","DOI":"10.1016\/j.celrep.2020.107827","article-title":"The PD-1 pathway regulates development and function of memory CD8+ T cells following respiratory viral infection","volume":"31","author":"Pauken","year":"2020","journal-title":"Cell Rep."},{"key":"2025020405435978700_r17","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/s41586-022-05626-9","article-title":"Functional T cells are capable of supernumerary cell division and longevity","volume":"614","author":"Soerens","year":"2023","journal-title":"Nature"},{"key":"2025020405435978700_r18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.12703\/P7-38","article-title":"Memory CD8 T cell transcriptional plasticity","volume":"7","author":"Youngblood","year":"2015","journal-title":"F1000Prime Rep."},{"key":"2025020405435978700_r19","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41577-021-00590-3","article-title":"The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues","volume":"22","author":"Kok","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"2025020405435978700_r20","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1084\/jem.20020369","article-title":"Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells","volume":"195","author":"Becker","year":"2002","journal-title":"J. Exp. Med."},{"key":"2025020405435978700_r21","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1084\/jem.20020033","article-title":"Cytokine requirements for acute and basal homeostatic proliferation of naive and memory CD8+ T cells","volume":"195","author":"Goldrath","year":"2002","journal-title":"J. Exp. Med."},{"key":"2025020405435978700_r22","doi-asserted-by":"crossref","first-page":"a028464","DOI":"10.1101\/cshperspect.a028464","article-title":"Cytokine-mediated regulation of CD8 T-cell responses during acute and chronic viral infection","volume":"11","author":"Hashimoto","year":"2019","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2025020405435978700_r23","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4049\/jimmunol.1300331","article-title":"FoxO1 controls effector-to-memory transition and maintenance of functional CD8 T cell memory","volume":"191","author":"Tejera","year":"2013","journal-title":"J. Immunol."},{"key":"2025020405435978700_r24","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/ni.1689","article-title":"Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor","volume":"10","author":"Kerdiles","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025020405435978700_r25","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.immuni.2019.09.013","article-title":"TCF-1-centered transcriptional network drives an effector versus exhausted CD8 T cell-fate decision","volume":"51","author":"Chen","year":"2019","journal-title":"Immunity"},{"key":"2025020405435978700_r26","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.4049\/jimmunol.1400557","article-title":"Too much of a good thing? Tim-3 and TCR signaling in T cell exhaustion","volume":"193","author":"Ferris","year":"2014","journal-title":"J. Immunol."},{"key":"2025020405435978700_r27","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/415536a","article-title":"Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease","volume":"415","author":"Monney","year":"2002","journal-title":"Nature"},{"key":"2025020405435978700_r28","doi-asserted-by":"crossref","first-page":"109699","DOI":"10.1016\/j.celrep.2021.109699","article-title":"Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment","volume":"36","author":"Banerjee","year":"2021","journal-title":"Cell Rep."},{"key":"2025020405435978700_r29","doi-asserted-by":"crossref","first-page":"101302","DOI":"10.1016\/j.smim.2019.101302","article-title":"Tim-3: a co-receptor with diverse roles in T cell exhaustion and tolerance","volume":"42","author":"Tang","year":"2019","journal-title":"Semin. Immunol."},{"key":"2025020405435978700_r30","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1084\/jem.20150388","article-title":"Tim-3 enhances Fc\u03b5RI-proximal signaling to modulate mast cell activation","volume":"212","author":"Phong","year":"2015","journal-title":"J. Exp. Med."},{"key":"2025020405435978700_r31","doi-asserted-by":"crossref","first-page":"534","DOI":"10.3892\/mmr.2020.11109","article-title":"Tim-3 regulates the ability of macrophages to counter lipopolysaccharide-induced pulmonary epithelial barrier dysfunction via the PI3K\/Akt pathway in epithelial cells","volume":"22","author":"Zhang","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"2025020405435978700_r32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41586-021-03626-9","article-title":"TIM-3 restrains anti-tumour immunity by regulating inflammasome activation","volume":"595","author":"Dixon","year":"2021","journal-title":"Nature"},{"key":"2025020405435978700_r33","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1182\/blood-2011-06-360321","article-title":"Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9","volume":"119","author":"Gleason","year":"2012","journal-title":"Blood"},{"key":"2025020405435978700_r34","doi-asserted-by":"crossref","first-page":"e40146","DOI":"10.1371\/journal.pone.0040146","article-title":"Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection","volume":"7","author":"Sakhdari","year":"2012","journal-title":"PLoS One"},{"key":"2025020405435978700_r35","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.4049\/jimmunol.1000156","article-title":"Regulation of virus-specific CD4+ T cell function by multiple costimulatory receptors during chronic HIV infection","volume":"185","author":"Kassu","year":"2010","journal-title":"J. Immunol."},{"key":"2025020405435978700_r36","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1002\/eji.201040340","article-title":"HCV-specific T cells in HCV\/HIV co-infection show elevated frequencies of dual Tim-3\/PD-1 expression that correlate with liver disease progression","volume":"40","author":"Vali","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"2025020405435978700_r37","doi-asserted-by":"crossref","first-page":"e1002984","DOI":"10.1371\/journal.ppat.1002984","article-title":"Tim-3-expressing CD4+ and CD8+ T cells in human tuberculosis (TB) exhibit polarized effector memory phenotypes and stronger anti-TB effector functions","volume":"8","author":"Qiu","year":"2012","journal-title":"PLoS Pathog."},{"key":"2025020405435978700_r38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/imr.12520","article-title":"Tim-3 and its role in regulating anti-tumor immunity","volume":"276","author":"Das","year":"2017","journal-title":"Immunol. Rev."},{"key":"2025020405435978700_r39","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1002\/eji.201948400","article-title":"TIM-3 and CEACAM1 do not interact in cis and in trans","volume":"50","author":"De Sousa Linhares","year":"2020","journal-title":"Eur. J. Immunol."},{"key":"2025020405435978700_r40","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.clim.2008.01.006","article-title":"Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis","volume":"127","author":"Seki","year":"2008","journal-title":"Clin. Immunol."},{"key":"2025020405435978700_r41","doi-asserted-by":"crossref","first-page":"e1000882","DOI":"10.1371\/journal.ppat.1000882","article-title":"Galectin-9\/TIM-3 interaction regulates virus-specific primary and memory CD8 T cell response","volume":"6","author":"Sehrawat","year":"2010","journal-title":"PLoS Pathog."},{"key":"2025020405435978700_r42","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1042\/BCJ20210425","article-title":"Phosphatidylserine binding directly regulates TIM-3 function","volume":"478","author":"Smith","year":"2021","journal-title":"Biochem. J."},{"key":"2025020405435978700_r43","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/ni1271","article-title":"The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity","volume":"6","author":"Zhu","year":"2005","journal-title":"Nat. Immunol."},{"key":"2025020405435978700_r44","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/nature13848","article-title":"CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. [Published erratum appears in 2016 Nature 536: 359.]","volume":"517","author":"Huang","year":"2015","journal-title":"Nature"},{"key":"2025020405435978700_r45","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1128\/MCB.05297-11","article-title":"Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways","volume":"31","author":"Lee","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"2025020405435978700_r46","doi-asserted-by":"crossref","first-page":"eaba0717","DOI":"10.1126\/scisignal.aba0717","article-title":"The costimulatory activity of Tim-3 requires Akt and MAPK signaling and its recruitment to the immune synapse","volume":"14","author":"Kataoka","year":"2021","journal-title":"Sci. Signal."},{"key":"2025020405435978700_r47","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.4049\/jimmunol.1302290","article-title":"Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection","volume":"192","author":"Gorman","year":"2014","journal-title":"J. Immunol."},{"key":"2025020405435978700_r48","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s12026-014-8524-1","article-title":"Regulation of T cell responses by the receptor molecule Tim-3","volume":"59","author":"Gorman","year":"2014","journal-title":"Immunol. Res."},{"key":"2025020405435978700_r49","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1073\/pnas.1712107115","article-title":"Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion","volume":"115","author":"Avery","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025020405435978700_r50","doi-asserted-by":"crossref","DOI":"10.1002\/9780471729259.mc15a01s8","article-title":"Lymphocytic choriomeningitis virus (LCMV): propagation, quantitation, and storage","author":"Welsh","year":"2008","journal-title":"Curr. Protoc. Microbiol."},{"key":"2025020405435978700_r51","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1084\/jem.160.2.521","article-title":"Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence","volume":"160","author":"Ahmed","year":"1984","journal-title":"J. Exp. Med."},{"key":"2025020405435978700_r52","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00281-015-0477-5","article-title":"Listeria monocytogenes: a model pathogen to study antigen-specific memory CD8 T cell responses","volume":"37","author":"Khan","year":"2015","journal-title":"Semin. Immunopathol."},{"key":"2025020405435978700_r53","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1073\/pnas.1718217115","article-title":"Role of PD-1 during effector CD8 T cell differentiation","volume":"115","author":"Ahn","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025020405435978700_r54","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev-immunol-042617-053214","article-title":"Tissue-resident T cells and other resident leukocytes","volume":"37","author":"Masopust","year":"2019","journal-title":"Annu. Rev. Immunol."},{"key":"2025020405435978700_r55","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.4049\/jimmunol.1900767","article-title":"Tissue-resident memory T cells in mice and humans: towards a quantitative ecology","volume":"203","author":"Morris","year":"2019","journal-title":"J. Immunol."},{"key":"2025020405435978700_r56","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nri778","article-title":"Effector and memory T-cell differentiation: implications for vaccine development","volume":"2","author":"Kaech","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"2025020405435978700_r57","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.4049\/jimmunol.1002145","article-title":"Increased numbers of preexisting memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells","volume":"187","author":"Joshi","year":"2011","journal-title":"J. Immunol."},{"key":"2025020405435978700_r58","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.immuni.2011.10.001","article-title":"Memory: the incomplete unhappening of differentiation","volume":"35","author":"Ballesteros-Tato","year":"2011","journal-title":"Immunity"},{"key":"2025020405435978700_r59","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41590-020-0607-7","article-title":"Developmental plasticity allows outside-in immune responses by resident memory T cells","volume":"21","author":"Fonseca","year":"2020","journal-title":"Nat. Immunol."},{"key":"2025020405435978700_r60","doi-asserted-by":"crossref","first-page":"5535","DOI":"10.1128\/JVI.78.11.5535-5545.2004","article-title":"Memory CD8 T-cell differentiation during viral infection","volume":"78","author":"Wherry","year":"2004","journal-title":"J. Virol."},{"key":"2025020405435978700_r61","doi-asserted-by":"crossref","first-page":"e1007633","DOI":"10.1371\/journal.ppat.1007633","article-title":"Central memory CD8+ T cells become CD69+ tissue-residents during viral skin infection independent of CD62L-mediated lymph node surveillance","volume":"15","author":"Osborn","year":"2019","journal-title":"PLoS Pathog."},{"key":"2025020405435978700_r62","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1084\/jem.20142237","article-title":"Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells","volume":"212","author":"Odorizzi","year":"2015","journal-title":"J. Exp. Med."},{"key":"2025020405435978700_r63","doi-asserted-by":"crossref","first-page":"316","DOI":"10.12688\/f1000research.13446.1","article-title":"Immune regulation by Tim-3","volume":"7","author":"Banerjee","year":"2018","journal-title":"F1000 Res."},{"key":"2025020405435978700_r64","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.4049\/jimmunol.179.5.2944","article-title":"Dynamics of CD8+ T cell responses during acute and chronic lymphocytic choriomeningitis virus infection","volume":"179","author":"Althaus","year":"2007","journal-title":"J. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/212\/3\/466\/61474420\/ji2300401.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/212\/3\/466\/61474420\/ji2300401.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T05:46:09Z","timestamp":1738647969000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/212\/3\/466\/7926053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,18]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,2,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2300401","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"type":"print","value":"0022-1767"},{"type":"electronic","value":"1550-6606"}],"subject":[],"published-other":{"date-parts":[[2024,2]]},"published":{"date-parts":[[2023,12,18]]}}}