{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:28:01Z","timestamp":1787030881111,"version":"build-2736575974"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001681"],"award-info":[{"award-number":["82001681"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371853"],"award-info":[{"award-number":["82371853"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81921005"],"award-info":[{"award-number":["81921005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Enterovirus 71 (EV71) is a significant causative agent of hand, foot, and mouth disease, with potential serious neurologic complications or fatal outcomes. The lack of effective treatments for EV71 infection is attributed to its elusive pathogenicity. Our study reveals that human plasmacytoid dendritic cells (pDCs), the main type I IFN\u2013producing cells, selectively express scavenger receptor class B, member 2 (SCARB2) and P-selectin glycoprotein ligand 1 (PSGL-1), crucial cellular receptors for EV71. Some strains of EV71 can replicate within pDCs and stimulate IFN-\u03b1 production. The activation of pDCs by EV71 is hindered by Abs to PSGL-1 and soluble PSGL-1, whereas Abs to SCARB2 and soluble SCARB2 have a less pronounced effect. Our data suggest that only strains binding to PSGL-1, more commonly found in severe cases, can replicate in pDCs and induce IFN-\u03b1 secretion, highlighting the importance of PSGL-1 in these processes. Furthermore, IFN-\u03b1 secretion by pDCs can be triggered by EV71 or UV-inactivated EV71 virions, indicating that productive infection is not necessary for pDC activation. These findings provide new insights into the interaction between EV71 and pDCs, suggesting that pDC activation could potentially mitigate the severity of EV71-related diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.2300407","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T09:20:13Z","timestamp":1713345613000},"page":"1782-1790","source":"Crossref","is-referenced-by-count":4,"title":["Enterovirus 71 Activates Plasmacytoid Dendritic Cell\u2013Dependent PSGL-1 Binding Independent of Productive Infection"],"prefix":"10.1093","volume":"212","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6305-1556","authenticated-orcid":false,"given":"Xuyuan","family":"Zhang","sequence":"first","affiliation":[{"name":"National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2916-5979","authenticated-orcid":false,"given":"Zhao","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Strategic Support Force Characteristic Medical Center, The Chinese People\u2019s Liberation Army , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialong","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Guo","sequence":"additional","affiliation":[{"name":"National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyun","family":"Li","sequence":"additional","affiliation":[{"name":"National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Nie","sequence":"additional","affiliation":[{"name":"National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Strategic Support Force Characteristic Medical Center, The Chinese People\u2019s Liberation Army , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9795-0314","authenticated-orcid":false,"given":"Liguo","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing ,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"2025020405503258900_r1","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S1474-4422(10)70209-X","article-title":"Clinical features, diagnosis, and management of enterovirus 71","volume":"9","author":"Ooi","year":"2010","journal-title":"Lancet Neurol."},{"key":"2025020405503258900_r2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12929-019-0574-1","article-title":"Enterovirus A71: virulence, antigenicity, and genetic evolution over the years","volume":"26","author":"Huang","year":"2019","journal-title":"J. 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