{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:39:08Z","timestamp":1771461548176,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"JSPS KAKENHI","award":["23K27426"],"award-info":[{"award-number":["23K27426"]}]},{"name":"JSPS KAKENHI","award":["22K07133"],"award-info":[{"award-number":["22K07133"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>IL-7 and IL-2 are evolutionarily related cytokines that play critical roles in the development and expansion of immune cells. Although both IL-7R and IL-2R activate similar signaling molecules, whether their signals have specific or overlapping functions during lymphocyte differentiation remains unclear. To address this question, we generated IL-7R \u03b1-chain (IL-7R\u03b1)\/IL-2R \u03b2-chain (IL-24\u03b2) (72R) knock-in mice expressing a chimeric receptor consisting of the extracellular domain of IL-7R\u03b1 and the intracellular domain of IL-2R\u03b2 under the control of the endogenous IL-7R\u03b1 promoter. Notably, this 72R receptor induced higher levels of STAT5 and Akt phosphorylation in T cells. In the periphery of 72R mice, the number of T cells, B cells, and type 2 innate lymphoid cells (ILC2s) was increased, whereas early T cell progenitors and double-negative 2 thymocytes were reduced in the thymus. In addition, cell proliferation and Notch signaling were impaired in the early thymocytes of 72R mice, leading to their differentiation into thymic B cells. Interestingly, ILC2s were increased in the thymus of 72R mice. Early T cell progenitors from 72R mice, but not from wild-type mice, differentiated into NK cells and ILC2-like cells when cocultured with a thymic stromal cell line. Thus, this study indicates that the chimeric 72R receptor transduces more robust signals than the authentic IL-7R\u03b1, thereby inducing the alternative differentiation of T cell progenitors into other cell lineages. This suggests that cytokine receptors may provide instructive signals for cell fate decisions.<\/jats:p>","DOI":"10.4049\/jimmunol.2300483","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T14:14:39Z","timestamp":1723644879000},"page":"952-964","source":"Crossref","is-referenced-by-count":2,"title":["A Chimeric IL-7R\u03b1\/IL-2R\u03b2 Receptor Promotes the Differentiation of T Cell Progenitors into B Cells and Type 2 Innate Lymphoid Cells"],"prefix":"10.1093","volume":"213","author":[{"given":"Akihiro","family":"Shimba","sequence":"first","affiliation":[{"name":"Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University , Kyoto ,","place":["Japan"]},{"name":"Department of Human Health Sciences, Graduate School of Medicine, Kyoto University , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2388-776X","authenticated-orcid":false,"given":"Shizue","family":"Tani-ichi","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University , Kyoto ,","place":["Japan"]},{"name":"Department of Human Health Sciences, Graduate School of Medicine, Kyoto University , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Masuda","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Department of Regeneration Science and Engineering, Institute for Life and Medical Sciences, Kyoto University , Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangwei","family":"Cui","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Munakata","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Abe","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satsuki","family":"Kitano","sequence":"additional","affiliation":[{"name":"Reproductive Engineering Team, Institute for Life and Medical Sciences, Kyoto University , Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4855-3857","authenticated-orcid":false,"given":"Hitoshi","family":"Miyachi","sequence":"additional","affiliation":[{"name":"Reproductive Engineering Team, Institute for Life and Medical Sciences, Kyoto University , Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Department of Regeneration Science and Engineering, Institute for Life and Medical Sciences, Kyoto University , Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1319-1021","authenticated-orcid":false,"given":"Koichi","family":"Ikuta","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"key":"2025012305170604200_r1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cytogfr.2005.05.004","article-title":"Cell biology of IL-7, a key lymphotrophin","volume":"16","author":"Jiang","year":"2005","journal-title":"Cytokine Growth Factor Rev."},{"key":"2025012305170604200_r2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nri1901","article-title":"The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design","volume":"6","author":"Waldmann","year":"2006","journal-title":"Nat. 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