{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:55:31Z","timestamp":1789167331019,"version":"build-2803163510"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RTG1949"],"award-info":[{"award-number":["RTG1949"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["LA2558\/8-1"],"award-info":[{"award-number":["LA2558\/8-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009400","name":"HHU | Medizinische Fakult\u00e4t, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf","doi-asserted-by":"publisher","award":["Project 9772816"],"award-info":[{"award-number":["Project 9772816"]}],"id":[{"id":"10.13039\/501100009400","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009400","name":"Juergen Manchot Graduate School","doi-asserted-by":"publisher","award":["MOI III"],"award-info":[{"award-number":["MOI III"]}],"id":[{"id":"10.13039\/501100009400","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009400","name":"The Christiane und Claudia Hempel Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009400","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009400","name":"The Volkswagen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009400","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Increased receptor binding affinity may allow viruses to escape from Ab-mediated inhibition. However, how high-affinity receptor binding affects innate immune escape and T cell function is poorly understood. In this study, we used the lymphocytic choriomeningitis virus (LCMV) murine infection model system to create a mutated LCMV exhibiting higher affinity for the entry receptor \u03b1-dystroglycan (LCMV-GPH155Y). We show that high-affinity receptor binding results in increased viral entry, which is associated with type I IFN (IFN-I) resistance, whereas initial innate immune activation was not impaired during high-affinity virus infection in mice. Consequently, IFN-I resistance led to defective antiviral T cell immunity, reduced type II IFN, and prolonged viral replication in this murine model system. Taken together, we show that high-affinity receptor binding of viruses can trigger innate affinity escape including resistance to IFN-I resulting in prolonged viral replication.<\/jats:p>","DOI":"10.4049\/jimmunol.2300637","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T13:07:17Z","timestamp":1710767237000},"page":"1457-1466","source":"Crossref","is-referenced-by-count":9,"title":["High-Affinity\u2013Mediated Viral Entry Triggers Innate Affinity Escape Resulting in Type I IFN Resistance and Impaired T Cell Immunity"],"prefix":"10.1093","volume":"212","author":[{"given":"Haifeng C","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University , D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyush","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University , D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University , D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9258-3626","authenticated-orcid":false,"given":"Michal","family":"Gorzkiewicz","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University , D\u00fcsseldorf ,","place":["Germany"]},{"name":"Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz , Lodz ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4451-7031","authenticated-orcid":false,"given":"D\u017eiuljeta","family":"Abromavi\u010di\u016bt\u0117","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University , D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4749-2941","authenticated-orcid":false,"given":"Constanze","family":"Tinz","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University , D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Virology, University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf , D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Meyer","sequence":"additional","affiliation":[{"name":"Institute of Virology, University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf , D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra A","family":"Pandyra","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich Heine University , D\u00fcsseldorf ,","place":["Germany"]},{"name":"Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn , Bonn ,","place":["Germany"]},{"name":"German Center for Infection Research, Partner Site Bonn-Cologne , Bonn ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8408-3063","authenticated-orcid":false,"given":"Aslihan","family":"Yavas","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Medical Faculty, Heinrich Heine University and University Hospital of D\u00fcsseldorf , D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6121-4737","authenticated-orcid":false,"given":"Arndt","family":"Borkhardt","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich Heine University , D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Esposito","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Medical Faculty, Heinrich Heine University and University Hospital of D\u00fcsseldorf , D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9783-7605","authenticated-orcid":false,"given":"Karl S","family":"Lang","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Medical Faculty, University of Duisburg-Essen , Essen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp A","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University , D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,18]]},"reference":[{"key":"2025020405490515900_r1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.virol.2015.03.043","article-title":"Viral membrane fusion","volume":"479\u2013480","author":"Harrison","year":"2015","journal-title":"Virology"},{"key":"2025020405490515900_r2","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/s41467-021-21118-2","article-title":"SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity","volume":"12","author":"Ozono","year":"2021","journal-title":"Nat. Commun."},{"key":"2025020405490515900_r3","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1126\/science.abe8499","article-title":"SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo","volume":"370","author":"Hou","year":"2020","journal-title":"Science"},{"key":"2025020405490515900_r4","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4149\/av_2013_02_160","article-title":"Lymphocytic choriomeningitis virus: invisible but not innocent","volume":"57","author":"Lapo\u0161ov\u00e1","year":"2013","journal-title":"Acta Virol."},{"key":"2025020405490515900_r5","doi-asserted-by":"crossref","first-page":"e53273","DOI":"10.1371\/journal.pone.0053273","article-title":"LCMV glycosylation modulates viral fitness and cell tropism","volume":"8","author":"Bonhomme","year":"2013","journal-title":"PLoS One."},{"key":"2025020405490515900_r6","doi-asserted-by":"crossref","first-page":"115196","DOI":"10.1016\/j.biopha.2023.115196","article-title":"The role of glycosylation patterns of viral glycoproteins and cell entry receptors in arenavirus infection","volume":"166","author":"Gorzkiewicz","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"2025020405490515900_r7","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1128\/JVI.06451-11","article-title":"Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry","volume":"86","author":"Shimojima","year":"2012","journal-title":"J. Virol."},{"key":"2025020405490515900_r8","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1292\/jvms.12-0176","article-title":"Cell surface molecules involved in infection mediated by lymphocytic choriomeningitis virus glycoprotein","volume":"74","author":"Shimojima","year":"2012","journal-title":"J. Vet. Med. Sci."},{"key":"2025020405490515900_r9","doi-asserted-by":"crossref","first-page":"e1009996","DOI":"10.1371\/journal.ppat.1009996","article-title":"Heparan sulfate proteoglycans serve as alternative receptors for low affinity LCMV variants","volume":"17","author":"Volland","year":"2021","journal-title":"PLoS Pathog."},{"key":"2025020405490515900_r10","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.virol.2004.05.009","article-title":"Use of alternative receptors different than alpha-dystroglycan by selected isolates of lymphocytic choriomeningitis virus","volume":"325","author":"Kunz","year":"2004","journal-title":"Virology"},{"key":"2025020405490515900_r11","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nsmb.3210","article-title":"Crystal structure of the prefusion surface glycoprotein of the prototypic arenavirus LCMV","volume":"23","author":"Hastie","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2025020405490515900_r12","doi-asserted-by":"crossref","first-page":"8438","DOI":"10.1128\/jvi.70.12.8438-8443.1996","article-title":"A single amino acid change in the glycoprotein of lymphocytic choriomeningitis virus is associated with the ability to cause growth hormone deficiency syndrome","volume":"70","author":"Teng","year":"1996","journal-title":"J. Virol."},{"key":"2025020405490515900_r13","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s42003-021-02028-x","article-title":"Slow viral propagation during initial phase of infection leads to viral persistence in mice","volume":"4","author":"Xu","year":"2021","journal-title":"Commun. Biol."},{"key":"2025020405490515900_r14","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/342559a0","article-title":"Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen","volume":"342","author":"Pircher","year":"1989","journal-title":"Nature"},{"key":"2025020405490515900_r15","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.immuni.2014.05.004","article-title":"Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity","volume":"40","author":"Xu","year":"2014","journal-title":"Immunity"},{"key":"2025020405490515900_r16","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00093-18","article-title":"TIM-1 mediates dystroglycan-independent entry of Lassa virus","volume":"92","author":"Brouillette","year":"2018","journal-title":"J. Virol."},{"key":"2025020405490515900_r17","doi-asserted-by":"crossref","first-page":"21641","DOI":"10.1073\/pnas.1011998107","article-title":"Viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression","volume":"107","author":"Bergthaler","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025020405490515900_r18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/hep.23640","article-title":"Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice","volume":"52","author":"Lang","year":"2010","journal-title":"Hepatology"},{"key":"2025020405490515900_r19","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/cdd.2012.167","article-title":"Reactive oxygen species delay control of lymphocytic choriomeningitis virus","volume":"20","author":"Lang","year":"2013","journal-title":"Cell Death Differ."},{"key":"2025020405490515900_r20","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1002\/hep4.1913","article-title":"Single MHC-I expression promotes virus-induced liver immunopathology","volume":"6","author":"Xu","year":"2022","journal-title":"Hepatol. Commun."},{"key":"2025020405490515900_r21","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nm1780","article-title":"Aggravation of viral hepatitis by platelet-derived serotonin","volume":"14","author":"Lang","year":"2008","journal-title":"Nat. Med."},{"key":"2025020405490515900_r22","doi-asserted-by":"crossref","first-page":"2000045","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000045","article-title":"Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR","volume":"25","author":"Corman","year":"2020","journal-title":"Euro. Surveill."},{"key":"2025020405490515900_r23","doi-asserted-by":"crossref","first-page":"e106230","DOI":"10.15252\/embj.2020106230","article-title":"SARS-CoV-2 targets neurons of 3D human brain organoids","volume":"39","author":"Ramani","year":"2020","journal-title":"EMBO J."},{"key":"2025020405490515900_r24","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nri888","article-title":"Viruses and interferon: a fight for supremacy","volume":"2","author":"Katze","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"2025020405490515900_r25","doi-asserted-by":"crossref","first-page":"9452","DOI":"10.1128\/JVI.00155-10","article-title":"Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus","volume":"84","author":"Zhou","year":"2010","journal-title":"J. Virol."},{"key":"2025020405490515900_r26","doi-asserted-by":"crossref","first-page":"e1003650","DOI":"10.1371\/journal.ppat.1003650","article-title":"Usp18 driven enforced viral replication in dendritic cells contributes to break of immunological tolerance in autoimmune diabetes","volume":"9","author":"Honke","year":"2013","journal-title":"PLoS Pathog."},{"key":"2025020405490515900_r27","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1128\/JVI.75.1.448-457.2001","article-title":"Differences in affinity of binding of lymphocytic choriomeningitis virus strains to the cellular receptor alpha-dystroglycan correlate with viral tropism and disease kinetics","volume":"75","author":"Smelt","year":"2001","journal-title":"J. Virol."},{"key":"2025020405490515900_r28","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1182\/blood-2007-10-117861","article-title":"Hematopoietic cell-derived interferon controls viral replication and virus-induced disease","volume":"113","author":"Lang","year":"2009","journal-title":"Blood"},{"key":"2025020405490515900_r29","doi-asserted-by":"crossref","first-page":"13038","DOI":"10.1128\/JVI.05834-11","article-title":"The C-terminal region of lymphocytic choriomeningitis virus nucleoprotein contains distinct and segregable functional domains involved in NP-Z interaction and counteraction of the type I interferon response","volume":"85","author":"Ortiz-Ria\u00f1o","year":"2011","journal-title":"J. Virol."},{"key":"2025020405490515900_r30","doi-asserted-by":"crossref","first-page":"e1006892","DOI":"10.1371\/journal.ppat.1006892","article-title":"Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na+\/K+ transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenaviruses","volume":"14","author":"Iwasaki","year":"2018","journal-title":"PLoS Pathog."},{"key":"2025020405490515900_r31","doi-asserted-by":"crossref","first-page":"eabd4585","DOI":"10.1126\/science.abd4585","article-title":"Autoantibodies against type I IFNs in patients with life-threatening COVID-19","volume":"370","author":"Bastard","year":"2020","journal-title":"Science"},{"key":"2025020405490515900_r32","doi-asserted-by":"crossref","first-page":"eabd4570","DOI":"10.1126\/science.abd4570","article-title":"Inborn errors of type I IFN immunity in patients with life-threatening COVID-19","volume":"370","author":"Zhang","year":"2020","journal-title":"Science"},{"key":"2025020405490515900_r33","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.cell.2022.01.001","article-title":"Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2","volume":"185","author":"Han","year":"2022","journal-title":"Cell"},{"key":"2025020405490515900_r34","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/362758a0","article-title":"Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells","volume":"362","author":"Moskophidis","year":"1993","journal-title":"Nature"},{"key":"2025020405490515900_r35","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/ni.2035","article-title":"T cell exhaustion","volume":"12","author":"Wherry","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025020405490515900_r36","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.3389\/fimmu.2017.01139","article-title":"Deciphering of the human interferon-regulated proteome by mass spectrometry-based quantitative analysis reveals extent and dynamics of protein induction and repression","volume":"8","author":"Megger","year":"2017","journal-title":"Front. Immunol."},{"key":"2025020405490515900_r37","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1126\/science.8009221","article-title":"Functional role of type I and type II interferons in antiviral defense","volume":"264","author":"M\u00fcller","year":"1994","journal-title":"Science"},{"key":"2025020405490515900_r38","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1128\/JVI.03349-14","article-title":"The Z proteins of pathogenic but not nonpathogenic arenaviruses inhibit RIG-I-like receptor-dependent interferon production","volume":"89","author":"Xing","year":"2015","journal-title":"J. Virol."},{"key":"2025020405490515900_r39","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/nature09605","article-title":"Cap binding and immune evasion revealed by Lassa nucleoprotein structure","volume":"468","author":"Qi","year":"2010","journal-title":"Nature"},{"key":"2025020405490515900_r40","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1073\/pnas.1016404108","article-title":"Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3\u2032 to 5\u2032 exonuclease activity essential for immune suppression","volume":"108","author":"Hastie","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025020405490515900_r41","doi-asserted-by":"crossref","first-page":"9192","DOI":"10.1128\/JVI.00555-06","article-title":"Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus","volume":"80","author":"Mart\u00ednez-Sobrido","year":"2006","journal-title":"J. Virol."},{"key":"2025020405490515900_r42","doi-asserted-by":"crossref","first-page":"12696","DOI":"10.1128\/JVI.00882-07","article-title":"Differential inhibition of type I interferon induction by arenavirus nucleoproteins","volume":"81","author":"Mart\u00ednez-Sobrido","year":"2007","journal-title":"J. Virol."},{"key":"2025020405490515900_r43","doi-asserted-by":"crossref","first-page":"8185","DOI":"10.1128\/JVI.07240-11","article-title":"Arenavirus nucleoproteins prevent activation of nuclear factor kappa B","volume":"86","author":"Rodrigo","year":"2012","journal-title":"J. Virol."},{"key":"2025020405490515900_r44","doi-asserted-by":"crossref","first-page":"e1011049","DOI":"10.1371\/journal.ppat.1011049","article-title":"A dsRNA-binding mutant reveals only a minor role of exonuclease activity in interferon antagonism by the arenavirus nucleoprotein","volume":"19","author":"Bohn","year":"2023","journal-title":"PLoS Pathog."},{"key":"2025020405490515900_r45","doi-asserted-by":"crossref","first-page":"7728","DOI":"10.1128\/JVI.00187-12","article-title":"Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKK\u03b5","volume":"86","author":"Pythoud","year":"2012","journal-title":"J. Virol."},{"key":"2025020405490515900_r46","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1128\/jvi.68.3.1951-1955.1994","article-title":"Resistance of lymphocytic choriomeningitis virus to alpha\/beta interferon and to gamma interferon","volume":"68","author":"Moskophidis","year":"1994","journal-title":"J. Virol."},{"key":"2025020405490515900_r47","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1126\/science.1235214","article-title":"Persistent LCMV infection is controlled by blockade of type I interferon signaling","volume":"340","author":"Teijaro","year":"2013","journal-title":"Science"},{"key":"2025020405490515900_r48","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1126\/science.1235208","article-title":"Blockade of chronic type I interferon signaling to control persistent LCMV infection","volume":"340","author":"Wilson","year":"2013","journal-title":"Science"},{"key":"2025020405490515900_r49","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.chom.2015.04.005","article-title":"Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection","volume":"17","author":"Ng","year":"2015","journal-title":"Cell Host Microbe"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/212\/9\/1457\/61474780\/ji2300637.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/212\/9\/1457\/61474780\/ji2300637.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T05:51:48Z","timestamp":1738648308000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/212\/9\/1457\/7926015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,18]]},"references-count":49,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,5,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2300637","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5]]},"published":{"date-parts":[[2024,3,18]]}}}