{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:09:29Z","timestamp":1788433769082,"version":"build-2803163510"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI101138"],"award-info":[{"award-number":["R01AI101138"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008747","name":"OSU | Center for Clinical and Translational Science, Ohio State University","doi-asserted-by":"publisher","award":["UL1TR002733"],"award-info":[{"award-number":["UL1TR002733"]}],"id":[{"id":"10.13039\/100008747","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>CMV infection and Th17 cells are independently associated with increased risk for late allograft loss after renal transplantation. Although CMV-specific Th17 cells are detectable in animal models and nontransplant clinical populations, evidence linking CMV and Th17 cells after renal transplantation remains unclear. This prospective observational study evaluated a cohort of renal transplant recipients during 12 mo posttransplant to assess the presence of CMV-specific Th17 cells in peripheral blood and their relationship to pretransplant CMV serostatus and CMV DNAemia. CMV-specific Th17 cells were identified among CMV serostatus donor (D)+ and\/or recipient (R)+ recipients and expanded during both primary (D+\/R\u2212) and reactivated (D+\/R+, D\u2212\/R+) CMV DNAemia. A subset of CMV-specific Th17 cells coexpressed IFN-\u03b3, indicating a Th1\/17 phenotype. These Th17 and Th1\/17 cells expressed CCR6, CCR5, activation and terminal differentiation markers (CD95, OX40, HLA-DR, CD57), and a central\/effector memory phenotype. CMV-specific Th1\/17 cells expressed activating\/inhibitory receptors (CD57, 4-1BB, CD160, CTLA-4, PD-1) at higher frequencies than Th17 cells. In contrast, staphylococcal enterotoxin B\u2013induced Th17 cells did not expand during CMV DNAemia, did not differ between CMV serostatus groups over time, expressed CCR6, predominantly coexpressed TNF-\u03b1, and had lower expression of activating and inhibitory receptors than pp65-specific Th17 and Th1\/17 cells. These data show that CMV-specific Th17 cells expand during episodes of CMV DNAemia among renal transplant recipients, and that these virus-specific Th17 and Th1\/17 cells have distinct phenotypes from global circulating Th(1)\/17 cells. These results suggest a potential proinflammatory pathway by which CMV-induced Th17 cells may contribute to allograft injury, increasing risk for late allograft loss.<\/jats:p>","DOI":"10.4049\/jimmunol.2300742","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T17:37:39Z","timestamp":1729273059000},"page":"1703-1712","source":"Crossref","is-referenced-by-count":2,"title":["Virus-specific Th17 Cells Are Induced by Human Cytomegalovirus after Renal Transplantation"],"prefix":"10.1093","volume":"213","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6180-2128","authenticated-orcid":false,"given":"Ravi","family":"Dhital","sequence":"first","affiliation":[{"name":"Center for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital , Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0739-6900","authenticated-orcid":false,"given":"Kaitlyn","family":"Flint","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital , Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4042-4428","authenticated-orcid":false,"given":"Irina","family":"Kaptsan","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital , Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0994-5071","authenticated-orcid":false,"given":"Shweta","family":"Hegde","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital , Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4354-326X","authenticated-orcid":false,"given":"Reem","family":"Daloul","sequence":"additional","affiliation":[{"name":"Division of Transplant Nephrology, Comprehensive Transplant Center, The Ohio State University , Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9952-351X","authenticated-orcid":false,"given":"Masako","family":"Shimamura","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital , Columbus OH"},{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics, The Ohio State University , Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"key":"2025020609294556100_r1","doi-asserted-by":"crossref","first-page":"e2034","DOI":"10.1002\/rmv.2034","article-title":"Estimation of the worldwide seroprevalence of cytomegalovirus: a systematic review and meta-analysis","volume":"29","author":"Zuhair","year":"2019","journal-title":"Rev. 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