{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:01:57Z","timestamp":1792789317869,"version":"4.5.0"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["18-20 - 345240311"],"award-info":[{"award-number":["18-20 - 345240311"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["CAN 2018\/350; no. 18 07 17"],"award-info":[{"award-number":["CAN 2018\/350; no. 18 07 17"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Central ALF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014689","name":"Region V\u00e4sternorrland","doi-asserted-by":"publisher","award":["LVNFOU992727"],"award-info":[{"award-number":["LVNFOU992727"]}],"id":[{"id":"10.13039\/501100014689","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014689","name":"Lions Cancer research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014689","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002960","name":"V\u00e4sterbotten L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002960","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endometriosis, affecting 10% of women, is defined as implantation, survival, and growth of endometrium-like\/endometriotic tissue outside the uterine cavity, causing inflammation, infertility, pain, and susceptibility to ovarian cancer. Despite extensive studies, its etiology and pathogenesis are poorly understood and largely unknown. The prevailing view is that the immune system of endometriosis patients fails to clear ectopically disseminated endometrium from retrograde menstruation. Exosomes are small extracellular vesicles that exhibit immunomodulatory properties. We studied the role of endometriotic tissue\u2013secreted exosomes in the pathophysiology of endometriosis. Two exosome-mediated mechanisms known to impair the immune response were investigated: 1) downregulation of NKG2D-mediated cytotoxicity and 2) FasL- and TRAIL-induced apoptosis of activated immune cells. We showed that secreted endometriotic exosomes isolated from supernatants of short-term explant cultures carry the NKG2D ligands MICA\/B and ULBP1-3 and the proapoptotic molecules FasL and TRAIL on their surface, i.e., signature molecules of exosome-mediated immune suppression. Acting as decoys, these exosomes downregulate the NKG2D receptor, impair NKG2D-mediated cytotoxicity, and induce apoptosis of activated PBMCs and Jurkat cells through the FasL- and TRAIL pathway. The secreted endometriotic exosomes create an immunosuppressive gradient at the ectopic site, forming a \u201cprotective shield\u201d around the endometriotic lesions. This gradient guards the endometriotic lesions against clearance by a cytotoxic attack and creates immunologic privilege by induction of apoptosis in activated immune cells. Taken together, our results provide a plausible, exosome-based mechanistic explanation for the immune dysfunction and the compromised immune surveillance in endometriosis and contribute novel insights into the pathogenesis of this enigmatic disease.<\/jats:p>","DOI":"10.4049\/jimmunol.2300781","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T09:20:32Z","timestamp":1720603232000},"page":"567-576","source":"Crossref","is-referenced-by-count":32,"title":["Endometriotic Tissue\u2013derived Exosomes Downregulate NKG2D-mediated Cytotoxicity and Promote Apoptosis: Mechanisms for Survival of Ectopic Endometrial Tissue in Endometriosis"],"prefix":"10.1093","volume":"213","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6920-5340","authenticated-orcid":false,"given":"Emma","family":"Bj\u00f6rk","sequence":"first","affiliation":[{"name":"Division of Obstetrics and Gynecology\/\u00d6rnsk\u00f6ldsvik Hospital , \u00d6rnsk\u00f6ldsvik ,","place":["Sweden"]},{"name":"Department of Clinical Microbiology\/Infection and Immunology, Ume\u00e5 University , Ume\u00e5 ,","place":["Sweden"]},{"name":"Department of Clinical Sciences\/Obstetrics and Gynecology, Ume\u00e5 University , Ume\u00e5 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8605-8122","authenticated-orcid":false,"given":"Pernilla","family":"Israelsson","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Intervention\/Oncology, Ume\u00e5 University , Ume\u00e5 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Nagaev","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology\/Infection and Immunology, Ume\u00e5 University , Ume\u00e5 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Nagaeva","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology\/Infection and Immunology, Ume\u00e5 University , Ume\u00e5 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Lundin","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences\/Pathology, Ume\u00e5 University , Ume\u00e5 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1383-7753","authenticated-orcid":false,"given":"Ulrika","family":"Ottander","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences\/Obstetrics and Gynecology, Ume\u00e5 University , Ume\u00e5 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6301-7940","authenticated-orcid":false,"given":"Lucia","family":"Mincheva-Nilsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology\/Infection and Immunology, Ume\u00e5 University , Ume\u00e5 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"2025012305141102600_r1","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1056\/NEJMra1810764","article-title":"Endometriosis","volume":"382","author":"Zondervan","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"2025012305141102600_r2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0015-0282(01)01816-7","article-title":"Role of cytokines in endometriosis","volume":"76","author":"Harada","year":"2001","journal-title":"Fertil. Steril."},{"key":"2025012305141102600_r3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1749-6632.2002.tb02761.x","article-title":"The epidemiology of endometriosis","volume":"955","author":"Cramer","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2025012305141102600_r4","first-page":"93","article-title":"Metastatic or embolic endometriosis, due to the menstrual dissemination of endometrial tissue into the venous circulation","volume":"3","author":"Sampson","year":"1927","journal-title":"Am. J. Pathol."},{"key":"2025012305141102600_r5","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis","volume":"364","author":"Giudice","year":"2004","journal-title":"Lancet"},{"key":"2025012305141102600_r6","first-page":"151","article-title":"Retrograde menstruation in healthy women and in patients with endometriosis","volume":"64","author":"Halme","year":"1984","journal-title":"Obstet. Gynecol."},{"key":"2025012305141102600_r7","first-page":"10","article-title":"How old is endometriosis? Late 17th- and 18th-century European descriptions of the disease","volume":"72","author":"Knapp","year":"1999","journal-title":"Fertil. Steril."},{"key":"2025012305141102600_r8","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.fertnstert.2015.06.035","article-title":"Heritability of endometriosis","volume":"104","author":"Saha","year":"2015","journal-title":"Fertil. Steril."},{"key":"2025012305141102600_r9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/jog.13559","article-title":"Involvement of immune cells in the pathogenesis of endometriosis","volume":"44","author":"Izumi","year":"2018","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"2025012305141102600_r10","doi-asserted-by":"crossref","first-page":"795976","DOI":"10.1155\/2015\/795976","article-title":"Pathophysiology and immune dysfunction in endometriosis","volume":"2015","author":"Ahn","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"2025012305141102600_r11","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1093\/humrep\/deu172","article-title":"An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression","volume":"29","author":"Kang","year":"2014","journal-title":"Hum. Reprod."},{"key":"2025012305141102600_r12","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/S0015-0282(16)55560-5","article-title":"In vitro lymphocyte activity in women with endometriosis\u2013an altered immune response?","volume":"58","author":"Gilmore","year":"1992","journal-title":"Fertil. Steril."},{"key":"2025012305141102600_r13","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0015-0282(16)54414-8","article-title":"Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium","volume":"56","author":"Oosterlynck","year":"1991","journal-title":"Fertil. Steril."},{"key":"2025012305141102600_r14","doi-asserted-by":"crossref","first-page":"R97","DOI":"10.1530\/JME-17-0227","article-title":"Dysfunctional signaling underlying endometriosis: current state of knowledge","volume":"60","author":"Cho","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"2025012305141102600_r15","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0015-0282(02)03320-4","article-title":"Elevated soluble Fas ligand levels may suggest a role for apoptosis in women with endometriosis","volume":"78","author":"Garcia-Velasco","year":"2002","journal-title":"Fertil. Steril."},{"key":"2025012305141102600_r16","doi-asserted-by":"crossref","first-page":"e13298","DOI":"10.1111\/aji.13298","article-title":"Enhanced local and systemic inflammatory cytokine mRNA expression in women with endometriosis evokes compensatory adaptive regulatory mRNA response that mediates immune suppression and impairs cytotoxicity","volume":"84","author":"Bj\u00f6rk","year":"2020","journal-title":"Am. J. Reprod. Immunol."},{"key":"2025012305141102600_r17","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1095\/biolreprod.115.134890","article-title":"Human endometrial exosomes contain hormone-specific cargo modulating trophoblast adhesive capacity: insights into endometrial\u2013embryo interactions","volume":"94","author":"Greening","year":"2016","journal-title":"Biol. Reprod."},{"key":"2025012305141102600_r18","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/biolre\/ioy212","article-title":"Eutopic stromal cells of endometriosis promote neuroangiogenesis via exosome pathway","volume":"100","author":"Sun","year":"2019","journal-title":"Biol. Reprod."},{"key":"2025012305141102600_r19","doi-asserted-by":"crossref","first-page":"e58502","DOI":"10.1371\/journal.pone.0058502","article-title":"Endometrial exosomes\/microvesicles in the uterine microenvironment: a new paradigm for embryo-endometrial cross talk at implantation","volume":"8","author":"Ng","year":"2013","journal-title":"PLoS One"},{"key":"2025012305141102600_r20","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.rbmo.2021.05.022","article-title":"Exosomes and their cargo are important regulators of cell function in endometriosis","volume":"43","author":"Freger","year":"2021","journal-title":"Reprod. Biomed. Online"},{"key":"2025012305141102600_r21","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1177\/1933719118808923","article-title":"Alteration of myeloid-derived suppressor cells, chronic inflammatory cytokines, and exosomal miRNA contribute to the peritoneal immune disorder of patients with endometriosis","volume":"26","author":"Chen","year":"2019","journal-title":"Reprod. Sci."},{"key":"2025012305141102600_r22","doi-asserted-by":"crossref","first-page":"e128846","DOI":"10.1172\/jci.insight.128846","article-title":"Extracellular vesicles from endometriosis patients are characterized by a unique miRNA-lncRNA signature","volume":"4","author":"Khalaj","year":"2019","journal-title":"JCI Insight"},{"key":"2025012305141102600_r23","first-page":"571","article-title":"Exosomal miR-22-3p derived from peritoneal macrophages enhances proliferation, migration, and invasion of ectopic endometrial stromal cells through regulation of the SIRT1\/NF-\u03baB signaling pathway","volume":"24","author":"Zhang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"2025012305141102600_r24","doi-asserted-by":"crossref","first-page":"112680","DOI":"10.1016\/j.biopha.2022.112680","article-title":"Endometriosis derived exosomal miR-301a-3p mediates macrophage polarization via regulating PTEN-PI3K axis","volume":"147","author":"Huang","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"2025012305141102600_r25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/molehr\/gay049","article-title":"Macrophages alternatively activated by endometriosis-exosomes contribute to the development of lesions in mice","volume":"25","author":"Sun","year":"2019","journal-title":"Mol. Hum. Reprod."},{"key":"2025012305141102600_r26","doi-asserted-by":"crossref","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J. Extracell. Vesicles"},{"key":"2025012305141102600_r27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"2025012305141102600_r28","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1073\/pnas.1702065114","article-title":"Formation and size distribution of self-assembled vesicles","volume":"114","author":"Huang","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2025012305141102600_r29","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.placenta.2020.03.002","article-title":"Placental small extracellular vesicles: Current questions and investigative opportunities","volume":"102","author":"Sadovsky","year":"2020","journal-title":"Placenta"},{"key":"2025012305141102600_r30","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00281-010-0234-8","article-title":"Exosomes\/microvesicles: mediators of cancer-associated immunosuppressive microenvironments","volume":"33","author":"Taylor","year":"2011","journal-title":"Semin. Immunopathol."},{"key":"2025012305141102600_r31","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00281-010-0233-9","article-title":"Exosomes: immune properties and potential clinical implementations","volume":"33","author":"Chaput","year":"2011","journal-title":"Semin. Immunopathol."},{"key":"2025012305141102600_r32","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3747\/co.v16i3.367","article-title":"Exosomes in tumour immunity","volume":"16","author":"Clayton","year":"2009","journal-title":"Curr. Oncol."},{"key":"2025012305141102600_r33","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1600-0897.2010.00822.x","article-title":"The role of placental exosomes in reproduction","volume":"63","author":"Mincheva-Nilsson","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"2025012305141102600_r34","doi-asserted-by":"crossref","first-page":"eaau6977","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"2025012305141102600_r35","doi-asserted-by":"crossref","first-page":"14.42.1","DOI":"10.1002\/cpim.17","article-title":"Isolation and Characterization of Exosomes from Cultures of Tissue Explants and Cell Lines","volume":"115","author":"Mincheva-Nilsson","year":"2016","journal-title":"Curr. Protoc. Immunol."},{"key":"2025012305141102600_r36","doi-asserted-by":"crossref","first-page":"5455","DOI":"10.1007\/s13277-015-4313-2","article-title":"Differential expression of ligands for NKG2D and DNAM-1 receptors by epithelial ovarian cancer-derived exosomes and its influence on NK cell cytotoxicity","volume":"37","author":"Labani-Motlagh","year":"2015","journal-title":"Tumour Biol."},{"key":"2025012305141102600_r37","doi-asserted-by":"crossref","first-page":"e16899","DOI":"10.1371\/journal.pone.0016899","article-title":"Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia\/lymphoma T and B cells","volume":"6","author":"Hedlund","year":"2011","journal-title":"PLoS One"},{"key":"2025012305141102600_r38","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4049\/jimmunol.0803477","article-title":"Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: evidence for immunosuppressive function","volume":"183","author":"Hedlund","year":"2009","journal-title":"J. Immunol."},{"key":"2025012305141102600_r39","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.4049\/jimmunol.1301885","article-title":"Exosomes secreted by human placenta carry functional Fas ligand and TRAIL molecules and convey apoptosis in activated immune cells, suggesting exosome-mediated immune privilege of the fetus","volume":"191","author":"Stenqvist","year":"2013","journal-title":"J. Immunol."},{"key":"2025012305141102600_r40","doi-asserted-by":"crossref","first-page":"e13647","DOI":"10.1111\/aji.13647","article-title":"NKG2D-mediated cytotoxicity improves after primary surgery for high-grade serous ovarian cancer","volume":"89","author":"Israelsson","year":"2022","journal-title":"Am. J. Reprod. Immunol."},{"key":"2025012305141102600_r41","doi-asserted-by":"crossref","first-page":"717884","DOI":"10.3389\/fimmu.2021.717884","article-title":"Immunosuppressive protein signatures carried by syncytiotrophoblast-derived exosomes and their role in human pregnancy","volume":"12","author":"Mincheva-Nilsson","year":"2021","journal-title":"Front. Immunol."},{"key":"2025012305141102600_r42","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0015-0282(97)81391-X","article-title":"Revised American Society for Reproductive Medicine classification of endometriosis: 1996","volume":"67","year":"1997","journal-title":"Fertil. Steril."},{"key":"2025012305141102600_r43","article-title":"Endometriosis","volume-title":"Pathology Outlines.","author":"Han","year":"2021"},{"key":"2025012305141102600_r44","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.4049\/jimmunol.176.6.3585","article-title":"Placenta-derived soluble MHC class I chain-related molecules down-regulate NKG2D receptor on peripheral blood mononuclear cells during human pregnancy: a possible novel immune escape mechanism for fetal survival","volume":"176","author":"Mincheva-Nilsson","year":"2006","journal-title":"J. Immunol."},{"key":"2025012305141102600_r45","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0022-1759(02)00330-7","article-title":"Production and characterization of clinical grade exosomes derived from dendritic cells","volume":"270","author":"Lamparski","year":"2002","journal-title":"J. Immunol. Methods"},{"key":"2025012305141102600_r46","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1034\/j.1600-0897.2002.01131.x","article-title":"Dominant IL-10 and TGF-beta mRNA expression in gammadeltaT cells of human early pregnancy decidua suggests immunoregulatory potential","volume":"48","author":"Nagaeva","year":"2002","journal-title":"Am. J. Reprod. Immunol."},{"key":"2025012305141102600_r47","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1084\/jem.20020797","article-title":"A signal peptide derived from hsp60 binds HLA-E and interferes with CD94\/NKG2A recognition","volume":"196","author":"Micha\u00eblsson","year":"2002","journal-title":"J. Exp. Med."},{"key":"2025012305141102600_r48","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s43032-020-00350-z","article-title":"Down-regulation of exosomal miR-214-3p targeting CCN2 contributes to endometriosis fibrosis and the role of exosomes in the horizontal transfer of miR-214-3p","volume":"28","author":"Zhang","year":"2021","journal-title":"Reprod. Sci."},{"key":"2025012305141102600_r49","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.fertnstert.2019.09.032","article-title":"Characterization of exosomes in peritoneal fluid of endometriosis patients","volume":"113","author":"Nazri","year":"2020","journal-title":"Fertil. Steril."},{"key":"2025012305141102600_r50","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1210\/clinem\/dgab045","article-title":"Characterization and proteomic analysis of endometrial stromal cell-derived small extracellular vesicles","volume":"106","author":"Hsu","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2025012305141102600_r51","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1007\/s10815-020-01833-3","article-title":"Molecular signature of eutopic endometrium in endometriosis based on the multi-omics integrative synthesis","volume":"37","author":"Pra\u0161nikar","year":"2020","journal-title":"J. Assist. Reprod. Genet."},{"key":"2025012305141102600_r52","doi-asserted-by":"crossref","first-page":"7249","DOI":"10.4049\/jimmunol.180.11.7249","article-title":"Human tumor-derived exosomes down-modulate NKG2D expression","volume":"180","author":"Clayton","year":"2008","journal-title":"J. Immunol."},{"key":"2025012305141102600_r53","doi-asserted-by":"crossref","first-page":"e0119961","DOI":"10.1371\/journal.pone.0119961","article-title":"Soluble ligands for the NKG2D receptor are released during endometriosis and correlate with disease severity","volume":"10","author":"Gonz\u00e1lez-Foruria","year":"2015","journal-title":"PLoS One"},{"key":"2025012305141102600_r54","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/nature01112","article-title":"Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation","volume":"419","author":"Groh","year":"2002","journal-title":"Nature"},{"key":"2025012305141102600_r55","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1158\/0008-5472.CAN-09-1688","article-title":"Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes","volume":"70","author":"Ashiru","year":"2010","journal-title":"Cancer. Res."},{"key":"2025012305141102600_r56","doi-asserted-by":"crossref","first-page":"102615","DOI":"10.1016\/j.jri.2019.102615","article-title":"Expressions of natural cytotoxicity receptor, NKG2D and NKG2D ligands in endometriosis","volume":"136","author":"Xu","year":"2019","journal-title":"J. Reprod. Immunol."},{"key":"2025012305141102600_r57","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/35103104","article-title":"The role of Fas ligand in immune privilege","volume":"2","author":"Green","year":"2001","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"2025012305141102600_r58","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3389\/fimmu.2012.00296","article-title":"The privileged immunity of immune privileged organs: the case of the eye","volume":"3","author":"Benhar","year":"2012","journal-title":"Front. Immunol."},{"key":"2025012305141102600_r59","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.4049\/jimmunol.169.9.4739","article-title":"TRAIL: a mechanism of tumor surveillance in an immune privileged site","volume":"169","author":"Lee","year":"2002","journal-title":"J. Immunol."},{"key":"2025012305141102600_r60","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1126\/science.1174621","article-title":"Lipid rafts as a membrane-organizing principle","volume":"327","author":"Lingwood","year":"2010","journal-title":"Science"},{"key":"2025012305141102600_r61","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3389\/fimmu.2017.00403","article-title":"Dual role of Fas\/FasL-mediated signal in peripheral immune tolerance","volume":"8","author":"Yamada","year":"2017","journal-title":"Front. Immunol."},{"key":"2025012305141102600_r62","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3389\/fimmu.2014.00144","article-title":"Human B cell\u2013derived lymphoblastoid cell lines constitutively produce Fas ligand and secrete MHCII+FasL+ killer exosomes","volume":"5","author":"Klinker","year":"2014","journal-title":"Front. Immunol."},{"key":"2025012305141102600_r63","doi-asserted-by":"crossref","first-page":"8442","DOI":"10.1096\/fj.201902186R","article-title":"Pancreatic cancer-derived exosomes induce apoptosis of T lymphocytes through the p38 MAPK-mediated endoplasmic reticulum stress","volume":"34","author":"Shen","year":"2020","journal-title":"FASEB J."},{"key":"2025012305141102600_r64","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jri.2011.08.005","article-title":"Dysregulation of the Fas\/FasL system in mononuclear cells recovered from peritoneal fluid of women with endometriosis","volume":"92","author":"Sturlese","year":"2011","journal-title":"J. Reprod. Immunol."},{"key":"2025012305141102600_r65","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1177\/1933719115594019","article-title":"Fas and Fas-ligand in eutopic and ectopic endometrium of women with endometriosis: the possible immune privilege of ectopic endometrium","volume":"23","author":"Sbracia","year":"2016","journal-title":"Reprod. Sci."},{"key":"2025012305141102600_r66","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.2147\/IJN.S291956","article-title":"A comprehensive review on factors influences biogenesis, functions, therapeutic and clinical implications of exosomes","volume":"16","author":"Gurunathan","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"2025012305141102600_r67","doi-asserted-by":"crossref","first-page":"354.e1","DOI":"10.1016\/j.ajog.2018.12.039","article-title":"Clinical diagnosis of endometriosis: a call to action","volume":"220","author":"Agarwal","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2025012305141102600_r68","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1111\/1471-0528.14055","article-title":"Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta-analysis","volume":"123","author":"Hirsch","year":"2016","journal-title":"BJOG"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/213\/5\/567\/61262227\/ji2300781.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/213\/5\/567\/61262227\/ji2300781.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:15:42Z","timestamp":1737591342000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/213\/5\/567\/7921641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,10]]},"references-count":68,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2300781","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,7,10]]}}}