{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:57:54Z","timestamp":1787752674535,"version":"build-2784847793"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31960163"],"award-info":[{"award-number":["31960163"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Jinggang Scholar Program of Jiangxi Province","award":["QD202205"],"award-info":[{"award-number":["QD202205"]}]},{"name":"The Research Team Project of Gannan Medical University","award":["TD2021JC01"],"award-info":[{"award-number":["TD2021JC01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>IFN regulatory factor 7 (IRF7) exerts anti-infective effects by promoting the production of IFNs in various bacterial and viral infections, but its role in highly morbid and fatal Candida albicans infections is unknown. We unexpectedly found that Irf7 gene expression levels were significantly upregulated in tissues or cells after C. albicans infection in humans and mice and that IRF7 actually exacerbates C. albicans infection in mice independent of its classical function in inducing IFNs production. Compared to controls, Irf7\u2212\/\u2212 mice showed stronger phagocytosis of fungus, upregulation of C-type lectin receptor CD209 expression, and enhanced P53\u2013AMPK\u2013mTOR\u2013mediated autophagic signaling in macrophages after C. albicans infection. The administration of the CD209-neutralizing Ab significantly hindered the phagocytosis of Irf7\u2212\/\u2212 mouse macrophages, whereas the inhibition of p53 or autophagy impaired the killing function of these macrophages. Thus, IRF7 exacerbates C. albicans infection by compromising the phagocytosis and killing capacity of macrophages via regulating CD209 expression and p53\u2013AMPK\u2013mTOR\u2013mediated autophagy, respectively. This finding reveals a novel function of IRF7 independent of its canonical IFNs production and its unexpected role in enhancing fungal infections, thus providing more specific and effective targets for antifungal therapy.<\/jats:p>","DOI":"10.4049\/jimmunol.2300826","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T14:01:26Z","timestamp":1715004086000},"page":"1932-1944","source":"Crossref","is-referenced-by-count":6,"title":["IRF7 Exacerbates <i>Candida albicans<\/i> Infection by Compromising CD209-Mediated Phagocytosis and Autophagy-Mediated Killing in Macrophages"],"prefix":"10.1093","volume":"212","author":[{"given":"Furong","family":"Qing","sequence":"first","affiliation":[{"name":"School of Basic Medicine; Gannan Medical University , Ganzhou, Jiangxi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Sui","sequence":"additional","affiliation":[{"name":"School of Basic Medicine; Gannan Medical University , Ganzhou, Jiangxi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenji","family":"He","sequence":"additional","affiliation":[{"name":"School of Basic Medicine; Gannan Medical University , Ganzhou, Jiangxi"},{"name":"School of Graduate, China Medical University , Shenyang, Liaoning"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayun","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Basic Medicine; Gannan Medical University , Ganzhou, Jiangxi"},{"name":"School of Graduate, China Medical University , Shenyang, Liaoning"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[{"name":"Center for Scientific Research, Gannan Medical University , Ganzhou, Jiangxi ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3597-5334","authenticated-orcid":false,"given":"Liangmei","family":"He","sequence":"additional","affiliation":[{"name":"School of Graduate, China Medical University , Shenyang, Liaoning"},{"name":"Department of Gastroenterology, First Affiliated Hospital, Gannan Medical University , Ganzhou, Jiangxi ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxiang","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Graduate, China Medical University , Shenyang, Liaoning"},{"name":"Department of Pathology, First Affiliated Hospital, Gannan Medical University , Ganzhou, Jiangxi ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianfu","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Basic Medicine; Gannan Medical University , Ganzhou, Jiangxi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5109-4153","authenticated-orcid":false,"given":"Zhiping","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Basic Medicine; Gannan Medical University , Ganzhou, Jiangxi"},{"name":"Center for Scientific Research, Gannan Medical University , Ganzhou, Jiangxi ,","place":["China"]},{"name":"Center for Immunology, Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University , Ganzhou, Jiangxi ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"2025020405511954500_r1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.2174\/138945005774912735","article-title":"Systemic fungal infections caused by Candida species: epidemiology, infection process and virulence attributes","volume":"6","author":"Mavor","year":"2005","journal-title":"Curr. 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