{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:13:16Z","timestamp":1777633996419,"version":"3.51.4"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32373023"],"award-info":[{"award-number":["32373023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The functions of the natural dsRNA sensors TLR3 (TRIF) and RIG-I (MAVS) are crucial during viral challenge and have not been accurately clarified in adaptive immune responses to rotavirus (RV) infection. In this study, we found that RV infection caused severe pathological damage to the small intestine of TLR3\u2212\/\u2212 and TRIF\u2212\/\u2212 mice. Our data found that dendritic cells from TLR3\u2212\/\u2212 and TRIF\u2212\/\u2212 mice had impaired Ag presentation to the RV and attenuated initiation of T cells upon viral infection. These attenuated functions resulted in impaired CD4+ T and CD8+ T function in mice lacking TLR3-TRIF signaling postinfection. Additionally, attenuated proliferative capacity of T cells from TLR3\u2212\/\u2212 and TRIF\u2212\/\u2212 mice was observed. Subsequently, we observed a significant reduction in the absolute number of memory T cells in the spleen and mesenteric lymph node (MLN) of TRIF\u2212\/\u2212 recipient mice following RV infection in a bone marrow chimeric model. Furthermore, there was reduced migration of type 2 classical dendritic cells from the intestine to MLNs after RV infection in TLR3\u2212\/\u2212 and TRIF\u2212\/\u2212 mice. Notably, RV infection resulted in attenuated killing of spleen and MLN tissues in TRIF\u2212\/\u2212 and MAVS\u2212\/\u2212 mice. Finally, we demonstrated that RV infection promoted apoptosis of CD8+ T cells in TRIF\u2212\/\u2212 and TLR3\u2212\/\u2212MAVS\u2212\/\u2212 mice. Taken together, our findings highlight an important mechanism of TLR3 signaling through TRIF in mucosal T cell responses to RV and lay the foundation for the development of a novel vaccine.<\/jats:p>","DOI":"10.4049\/jimmunol.2300867","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T13:54:11Z","timestamp":1724853251000},"page":"1008-1022","source":"Crossref","is-referenced-by-count":13,"title":["TLR3\/TRIF and MAVS Signaling Is Essential in Regulating Mucosal T Cell Responses during Rotavirus Infection"],"prefix":"10.1093","volume":"213","author":[{"given":"Rong-Rong","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding, Engineering Research Center of Microecological Vaccines (Drugs) for Major Animal Diseases, Ministry of Education, Jilin Agricultural University , Changchun ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Yao","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding, Engineering Research Center of Microecological Vaccines (Drugs) for Major Animal Diseases, Ministry of Education, Jilin Agricultural University , Changchun ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Lei","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding, Engineering Research Center of Microecological Vaccines (Drugs) for Major Animal Diseases, Ministry of Education, Jilin Agricultural University , Changchun ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian-Kui","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding, Engineering Research Center of Microecological Vaccines (Drugs) for Major Animal Diseases, Ministry of Education, Jilin Agricultural University , Changchun ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Shu","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding, Engineering Research Center of Microecological Vaccines (Drugs) for Major Animal Diseases, Ministry of Education, Jilin Agricultural University , Changchun ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Shi","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding, Engineering Research Center of Microecological Vaccines (Drugs) for Major Animal Diseases, Ministry of Education, Jilin Agricultural University , Changchun ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Wei","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding, Engineering Research Center of Microecological Vaccines (Drugs) for Major Animal Diseases, Ministry of Education, Jilin Agricultural University , Changchun ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui-Lian","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding, Engineering Research Center of Microecological Vaccines (Drugs) for Major Animal Diseases, Ministry of Education, Jilin Agricultural University , Changchun ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Bin","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding, Engineering Research Center of Microecological Vaccines (Drugs) for Major Animal Diseases, Ministry of Education, Jilin Agricultural University , Changchun ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Zhong","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding, Engineering Research Center of Microecological Vaccines (Drugs) for Major Animal Diseases, Ministry of Education, Jilin Agricultural University , Changchun ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Long","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding, Engineering Research Center of Microecological Vaccines (Drugs) for Major Animal Diseases, Ministry of Education, Jilin Agricultural University , Changchun ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3459-7207","authenticated-orcid":false,"given":"Xin","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding, Engineering Research Center of Microecological Vaccines (Drugs) for Major Animal Diseases, Ministry of Education, Jilin Agricultural University , Changchun ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding, Engineering Research Center of Microecological Vaccines (Drugs) for Major Animal Diseases, Ministry of Education, Jilin Agricultural University , Changchun ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7894-7523","authenticated-orcid":false,"given":"Yan","family":"Zeng","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding, Engineering Research Center of Microecological Vaccines (Drugs) for Major Animal Diseases, Ministry of Education, Jilin Agricultural University , Changchun ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Tao","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding, Engineering Research Center of Microecological Vaccines (Drugs) for Major Animal Diseases, Ministry of Education, Jilin Agricultural University , Changchun ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding, Engineering Research Center of Microecological Vaccines (Drugs) for Major Animal Diseases, Ministry of Education, Jilin Agricultural University , Changchun ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"key":"2025012305170102000_r1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12929-020-00649-8","article-title":"Rotavirus infection in children in Southeast Asia 2008-2018: disease burden, genotype distribution, seasonality, and vaccination","volume":"27","author":"Lestari","year":"2020","journal-title":"J. Biomed. Sci."},{"key":"2025012305170102000_r2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/INF.0000000000003463","article-title":"Rotavirus infection in children &lt;5 years of age in Suzhou, China, 2013\u20132019: disease burden, genotype distribution and seasonality","volume":"41","author":"Shen","year":"2022","journal-title":"Pediatr. Infect. Dis. J."},{"key":"2025012305170102000_r3","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3389\/fimmu.2016.00563","article-title":"Intestinal innate antiviral immunity and immunobiotics: beneficial effects against rotavirus infection","volume":"7","author":"Villena","year":"2016","journal-title":"Front. Immunol."},{"key":"2025012305170102000_r4","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.4049\/jimmunol.1002862","article-title":"RIG-I\/MDA5\/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epithelium","volume":"186","author":"Broquet","year":"2011","journal-title":"J. Immunol."},{"key":"2025012305170102000_r5","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/eji.202048990","article-title":"Rotavirus infection causes mesenteric lymph node hypertrophy independently of type I interferon or TNF-\u03b1 in mice","volume":"51","author":"Nakawesi","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"2025012305170102000_r6","doi-asserted-by":"crossref","first-page":"6812","DOI":"10.1128\/JVI.00450-08","article-title":"Qualitative and quantitative characteristics of rotavirus-specific CD8 T cells vary depending on the route of infection","volume":"82","author":"Jiang","year":"2008","journal-title":"J. Virol."},{"key":"2025012305170102000_r7","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1089\/vim.2007.0055","article-title":"IFN-gamma is the only anti-rotavirus cytokine found after in vitro stimulation of memory CD4+ T cells from mice immunized with a chimeric VP6 protein","volume":"20","author":"McNeal","year":"2007","journal-title":"Viral Immunol."},{"key":"2025012305170102000_r8","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1016\/j.vaccine.2015.03.080","article-title":"Targeting of rotavirus VP6 to DEC-205 induces protection against the infection in mice","volume":"33","author":"Badillo-Godinez","year":"2015","journal-title":"Vaccine"},{"key":"2025012305170102000_r9","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.4049\/jimmunol.0903013","article-title":"Cutting edge: priming of CD8 T cell immunity to herpes simplex virus type 1 requires cognate TLR3 expression in vivo","volume":"184","author":"Davey","year":"2010","journal-title":"J. Immunol."},{"key":"2025012305170102000_r10","doi-asserted-by":"crossref","first-page":"814491","DOI":"10.3389\/fimmu.2022.814491","article-title":"Rotavirus-induced expansion of antigen-specific CD8 T cells does not require signaling via TLR3, MyD88 or the type I interferon receptor","volume":"13","author":"Muleta","year":"2022","journal-title":"Front. Immunol."},{"key":"2025012305170102000_r11","doi-asserted-by":"crossref","first-page":"e1006382","DOI":"10.1371\/journal.ppat.1006382","article-title":"The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-kappaB mediated transcription","volume":"13","author":"Chan","year":"2017","journal-title":"PLoS Pathog."},{"key":"2025012305170102000_r12","doi-asserted-by":"crossref","first-page":"572747","DOI":"10.3389\/fimmu.2020.572747","article-title":"MAVS deficiency is associated with a reduced T cell response upon secondary RSV infection in mice","volume":"11","author":"Paulsen","year":"2020","journal-title":"Front. Immunol."},{"key":"2025012305170102000_r13","doi-asserted-by":"crossref","first-page":"e02097-16","DOI":"10.1128\/JVI.02097-16","article-title":"MAVS is essential for primary CD4+ T cell immunity but not for recall T cell responses following an attenuated West Nile virus infection","volume":"91","author":"Luo","year":"2017","journal-title":"J. Virol."},{"key":"2025012305170102000_r14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41385-020-0276-8","article-title":"\u03b1v\u03b28 Integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to rotavirus","volume":"14","author":"Nakawesi","year":"2021","journal-title":"Mucosal Immunol."},{"key":"2025012305170102000_r15","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/mi.2016.79","article-title":"Intestinal Batf3-dependent dendritic cells are required for optimal antiviral T-cell responses in adult and neonatal mice","volume":"10","author":"Sun","year":"2017","journal-title":"Mucosal Immunol."},{"key":"2025012305170102000_r16","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.virol.2014.07.011","article-title":"Immunoprotection against influenza virus H9N2 by the oral administration of recombinant Lactobacillus plantarum NC8 expressing hemagglutinin in BALB\/c mice","volume":"464-465","author":"Shi","year":"2014","journal-title":"Virology"},{"key":"2025012305170102000_r17","doi-asserted-by":"crossref","first-page":"39665","DOI":"10.1038\/srep39665","article-title":"Cross-protective efficacy of dendritic cells targeting conserved influenza virus antigen expressed by Lactobacillus plantarum","volume":"6","author":"Yang","year":"2016","journal-title":"Sci. Rep."},{"key":"2025012305170102000_r18","doi-asserted-by":"crossref","first-page":"e1005754","DOI":"10.1371\/journal.ppat.1005754","article-title":"RIG-I signaling is critical for efficient polyfunctional T cell responses during influenza virus infection","volume":"12","author":"Kandasamy","year":"2016","journal-title":"PLoS Pathog."},{"key":"2025012305170102000_r19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jviromet.2019.01.017","article-title":"Evaluation of different genomic regions of rotavirus A for development of real time PCR","volume":"266","author":"Joshi","year":"2019","journal-title":"J. Virol. Methods"},{"key":"2025012305170102000_r20","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.4049\/jimmunol.2100102","article-title":"Lactobacillus rhamnosus GG promotes early B lineage development and IgA production in the lamina propria in piglets","volume":"207","author":"Jin","year":"2021","journal-title":"J. Immunol."},{"key":"2025012305170102000_r21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/viro.1997.8843","article-title":"Immunity to rotavirus in T cell deficient mice","volume":"238","author":"Franco","year":"1997","journal-title":"Virology"},{"key":"2025012305170102000_r22","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/mi.2017.28","article-title":"Neonatal mice possess two phenotypically and functionally distinct lung-migratory CD103+ dendritic cell populations following respiratory infection","volume":"11","author":"Ruckwardt","year":"2018","journal-title":"Mucosal Immunol."},{"key":"2025012305170102000_r23","doi-asserted-by":"crossref","first-page":"198499","DOI":"10.1016\/j.virusres.2021.198499","article-title":"Rotavirus research: 2014-2020","volume":"304","author":"Caddy","year":"2021","journal-title":"Virus Res."},{"key":"2025012305170102000_r24","doi-asserted-by":"crossref","first-page":"e1002670","DOI":"10.1371\/journal.ppat.1002670","article-title":"Age-dependent TLR3 expression of the intestinal epithelium contributes to rotavirus susceptibility","volume":"8","author":"Pott","year":"2012","journal-title":"PLoS Pathog."},{"key":"2025012305170102000_r25","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11262-016-1419-6","article-title":"Rotavirus NSP486-175 interacts with H9c2(2-1) cells in vitro, elevates intracellular Ca2+ levels and can become cytotoxic: a possible mechanism for extra-intestinal pathogenesis","volume":"53","author":"Xiong","year":"2017","journal-title":"Virus Genes"},{"key":"2025012305170102000_r26","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.molcel.2023.02.024","article-title":"m6A-driven SF3B1 translation control steers splicing to direct genome integrity and leukemogenesis","volume":"83","author":"Cie\u015bla","year":"2023","journal-title":"Mol. Cell"},{"key":"2025012305170102000_r27","doi-asserted-by":"crossref","first-page":"4413","DOI":"10.1038\/s41467-021-24703-7","article-title":"TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer","volume":"12","author":"Xu","year":"2021","journal-title":"Nat. Commun."},{"key":"2025012305170102000_r28","doi-asserted-by":"crossref","first-page":"9001","DOI":"10.1038\/s41598-023-35681-9","article-title":"Acute rotavirus infection is associated with the induction of circulating memory CD4+ T cell subsets","volume":"13","author":"Malamba-Banda","year":"2023","journal-title":"Sci. Rep."},{"key":"2025012305170102000_r29","doi-asserted-by":"crossref","first-page":"18533","DOI":"10.1038\/srep18533","article-title":"T cell responses are elicited against respiratory syncytial virus in the absence of signalling through TLRs, RLRs and IL-1R\/IL-18R","volume":"5","author":"Goritzka","year":"2015","journal-title":"Sci. Rep."},{"key":"2025012305170102000_r30","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.cell.2019.09.028","article-title":"Segmented filamentous bacteria prevent and cure rotavirus infection","volume":"179","author":"Shi","year":"2019","journal-title":"Cell"},{"key":"2025012305170102000_r31","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1128\/JVI.01640-07","article-title":"Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88","volume":"82","author":"Jung","year":"2008","journal-title":"J. Virol."},{"key":"2025012305170102000_r32","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.4049\/jimmunol.0901140","article-title":"MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3","volume":"183","author":"Kenny","year":"2009","journal-title":"J. Immunol."},{"key":"2025012305170102000_r33","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.3390\/cells9081910","article-title":"TLR3-dependent activation of TLR2 endogenous ligands via the MyD88 signaling pathway augments the innate immune response","volume":"9","author":"Teixeira","year":"2020","journal-title":"Cells"},{"key":"2025012305170102000_r34","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1002\/eji.201344248","article-title":"Autophagy plays a protective role as an anti-oxidant system in human T cells and represents a novel strategy for induction of T-cell apoptosis","volume":"44","author":"Watanabe","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"2025012305170102000_r35","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3390\/v12040381","article-title":"Autophagy induced by simian retrovirus infection controls viral replication and apoptosis of Jurkat T lymphocytes","volume":"12","author":"Zhu","year":"2020","journal-title":"Viruses"},{"key":"2025012305170102000_r36","doi-asserted-by":"crossref","first-page":"13131","DOI":"10.1038\/s41598-020-69959-z","article-title":"Porcine reproductive and respiratory syndrome virus infection induces endoplasmic reticulum stress, facilitates virus replication, and contributes to autophagy and apoptosis","volume":"10","author":"Chen","year":"2020","journal-title":"Sci. Rep."},{"key":"2025012305170102000_r37","doi-asserted-by":"crossref","first-page":"13577","DOI":"10.1038\/s41598-017-14082-9","article-title":"Autophagy induces apoptosis and death of T lymphocytes in the spleen of pigs infected with CSFV","volume":"7","author":"Gou","year":"2017","journal-title":"Sci. Rep."},{"key":"2025012305170102000_r38","doi-asserted-by":"crossref","first-page":"e02193-17","DOI":"10.1128\/JVI.02193-17","article-title":"Respiratory syncytial virus replication is promoted by autophagy-mediated inhibition of apoptosis","volume":"92","author":"Li","year":"2018","journal-title":"J. Virol."},{"key":"2025012305170102000_r39","doi-asserted-by":"crossref","first-page":"16677","DOI":"10.1073\/pnas.0808597105","article-title":"FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells","volume":"105","author":"Bell","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2025012305170102000_r40","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1002\/eji.201948497","article-title":"Migration of murine intestinal dendritic cell subsets upon intrinsic and extrinsic TLR3 stimulation","volume":"50","author":"Garcias L\u00f3pez","year":"2020","journal-title":"Eur. J. Immunol."},{"key":"2025012305170102000_r41","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.immuni.2021.10.020","article-title":"Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity","volume":"55","author":"Duong","year":"2022","journal-title":"Immunity"},{"key":"2025012305170102000_r42","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/mi.2017.48","article-title":"Toll-like receptor 3 in nasal CD103+ dendritic cells is involved in immunoglobulin A production","volume":"11","author":"Takaki","year":"2018","journal-title":"Mucosal Immunol."},{"key":"2025012305170102000_r43","doi-asserted-by":"crossref","first-page":"eabf4432","DOI":"10.1126\/sciimmunol.abf4432","article-title":"Type 1 conventional dendritic cell fate and function are controlled by DC-SCRIPT","volume":"6","author":"Zhang","year":"2021","journal-title":"Sci. Immunol."},{"key":"2025012305170102000_r44","doi-asserted-by":"crossref","first-page":"10872","DOI":"10.1073\/pnas.1934678100","article-title":"Selective contribution of IFN-alpha\/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection","volume":"100","author":"Honda","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2025012305170102000_r45","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.micpath.2017.07.015","article-title":"Murine bone marrow-derived DCs activated by porcine rotavirus stimulate the Th1 subtype response in vitro","volume":"110","author":"Ye","year":"2017","journal-title":"Microb. Pathog."},{"key":"2025012305170102000_r46","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nature03326","article-title":"Toll-like receptor 3 promotes cross-priming to virus-infected cells","volume":"433","author":"Schulz","year":"2005","journal-title":"Nature"},{"key":"2025012305170102000_r47","doi-asserted-by":"crossref","first-page":"eadf4919","DOI":"10.1126\/sciimmunol.adf4919","article-title":"Noncanonical MAVS signaling restrains dendritic cell-driven antitumor immunity by inhibiting IL-12","volume":"8","author":"Wu","year":"2023","journal-title":"Sci. Immunol."},{"key":"2025012305170102000_r48","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/ni.2514","article-title":"IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8+ T cell responses to influenza A virus","volume":"14","author":"Pang","year":"2013","journal-title":"Nat. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/213\/7\/1008\/61539437\/ji2300867.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/213\/7\/1008\/61539437\/ji2300867.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T05:18:12Z","timestamp":1737609492000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/213\/7\/1008\/7925924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,28]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,10,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2300867","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,10]]},"published":{"date-parts":[[2024,8,28]]}}}