{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:19:45Z","timestamp":1788477585141,"version":"build-2803163510"},"reference-count":93,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI167884-01A1"],"award-info":[{"award-number":["AI167884-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI107668"],"award-info":[{"award-number":["AI107668"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mast cells (MCs) play critical roles in the establishment of allergic diseases. We recently demonstrated an unexpected, proinflammatory role for IL-10 in regulating MC responses. IL-10 enhanced MC activation and promoted IgE-dependent responses during food allergy. However, whether these effects extend to IgE-independent stimuli is not clear. In this article, we demonstrate that IL-10 plays a critical role in driving IL-33\u2013mediated MC responses. IL-10 stimulation enhanced MC expansion and degranulation, ST2 expression, IL-13 production, and phospho-relA upregulation in IL-33\u2013treated cells while suppressing TNF-\u03b1. These effects were partly dependent on endogenous IL-10 and further amplified in MCs coactivated with both IL-33 and IgE\/Ag. IL-10\u2019s divergent effects also extended in vivo. In a MC-dependent model of IL-33\u2013induced neutrophilia, IL-10 treatment enhanced MC responsiveness, leading to suppression of neutrophils and decreased TNF-\u03b1. In contrast, during IL-33\u2013induced type 2 inflammation, IL-10 priming exacerbated MC activity, resulting in MC recruitment to various tissues, enhanced ST2 expression, induction of hypothermia, recruitment of eosinophils, and increased MCPT-1 and IL-13 levels. Our data elucidate an important role for IL-10 as an augmenter of IL-33\u2013mediated MC responses, with implications during both allergic diseases and other MC-dependent disorders. IL-10 induction is routinely used as a prognostic marker of disease improvement. Our data suggest instead that IL-10 can enhance ST2 responsiveness in IL-33\u2013activated MCs, with the potential to both aggravate or suppress disease severity depending on the inflammatory context.<\/jats:p>","DOI":"10.4049\/jimmunol.2300884","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T13:07:15Z","timestamp":1710767235000},"page":"1407-1419","source":"Crossref","is-referenced-by-count":6,"title":["IL-10 Differentially Promotes Mast Cell Responsiveness to IL-33, Resulting in Enhancement of Type 2 Inflammation and Suppression of Neutrophilia"],"prefix":"10.1093","volume":"212","author":[{"given":"Saurav","family":"Ranjitkar","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences, University of Connecticut , Storrs, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Krajewski","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Administrative Sciences, Western New England University , Springfield, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7681-695X","authenticated-orcid":false,"given":"Chelsea","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Connecticut , Storrs, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Tedeschi","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Connecticut , Storrs, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3323-2374","authenticated-orcid":false,"given":"Stephanie H","family":"Polukort","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Administrative Sciences, Western New England University , Springfield, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Rovatti","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Administrative Sciences, Western New England University , Springfield, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2468-5289","authenticated-orcid":false,"given":"Mohamed","family":"Mire","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Administrative Sciences, Western New England University , Springfield, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher N","family":"Blesso","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Connecticut , Storrs, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2674-1605","authenticated-orcid":false,"given":"Evan","family":"Jellison","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Connecticut , Farmington, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0093-4308","authenticated-orcid":false,"given":"Sallie S","family":"Schneider","sequence":"additional","affiliation":[{"name":"Pioneer Valley Life Sciences Institute, Baystate Medical Center , Springfield, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Biology, Virginia Commonwealth University , Richmond, VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0223-4842","authenticated-orcid":false,"given":"Clinton B","family":"Mathias","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Connecticut , Storrs, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,18]]},"reference":[{"key":"2025020405491070600_r1","doi-asserted-by":"crossref","first-page":"17098","DOI":"10.1038\/nrdp.2017.98","article-title":"Food allergy","volume":"4","author":"Renz","year":"2018","journal-title":"Nat. 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