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Constant interactions between stroma and tissue-confined immune cells maintain skin homeostasis. However, the cellular interactions that maintain skin health also contribute to focal immunopathology. Psoriasis is a common disease that manifests with focal pathology induced by environmental triggers in genetically susceptible individuals. Within psoriasis plaques, cross-talk between skin-resident T cells and stroma cells leads to chronic inflammation. Inflammatory cytokines such as TNF-\u03b1, IL-17, IL-22, and IL-23 amplify the local chronic inflammation and sustain the well-demarcated thick and scaly plaques that characterize the disease. In resolved lesions, T cells remain poised for IL-17 and IL-22 production, and postinflammatory epigenetic modifications lower the threshold for initiation of local relapse. This review focuses on how tissue-resident memory T cells contribute to the onset, maintenance, resolution, and relapse of psoriasis.<\/jats:p>","DOI":"10.4049\/jimmunol.2400020","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T16:00:32Z","timestamp":1729526432000},"page":"1267-1277","source":"Crossref","is-referenced-by-count":13,"title":["Skin-resident T Cells Contribute to the Dynamic Disease Manifestations of Psoriasis"],"prefix":"10.1093","volume":"213","author":[{"given":"Daniel","family":"Sortebech","sequence":"first","affiliation":[{"name":"Department of Medicine Solna, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine","family":"Schoenfeldt","sequence":"additional","affiliation":[{"name":"Leo Foundation Skin Immunology Research Center, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2343-6515","authenticated-orcid":false,"given":"Albert","family":"Duvetorp","sequence":"additional","affiliation":[{"name":"Leo Foundation Skin Immunology Research Center, University of Copenhagen , Copenhagen ,","place":["Denmark"]},{"name":"Department of Dermatology, Sk\u00e5ne University Hospital , Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4884-706X","authenticated-orcid":false,"given":"Rasmus","family":"Agerholm-Nielsen","sequence":"additional","affiliation":[{"name":"Leo Foundation Skin Immunology Research Center, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9237-8374","authenticated-orcid":false,"given":"Liv","family":"Eidsmo","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna, Karolinska Institutet , Stockholm ,","place":["Sweden"]},{"name":"Leo Foundation Skin Immunology Research Center, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,1]]},"reference":[{"key":"2025020609283486800_r1","doi-asserted-by":"crossref","first-page":"m1590","DOI":"10.1136\/bmj.m1590","article-title":"National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study","volume":"369","author":"Parisi","year":"2020","journal-title":"BMJ"},{"key":"2025020609283486800_r2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1159\/000509732","article-title":"Sex and age influence the associated risk of depression in patients with psoriasis: a retrospective population study based on diagnosis and drug-use","volume":"237","author":"Duvetorp","year":"2021","journal-title":"Dermatology"},{"key":"2025020609283486800_r3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000251595","article-title":"The natural history of psoriasis in 5,600 patients","volume":"148","author":"Farber","year":"1974","journal-title":"Dermatologica"},{"key":"2025020609283486800_r4","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1001\/jamadermatol.2021.0734","article-title":"Long-term outcomes and prognosis in new-onset psoriasis","volume":"157","author":"Svedbom","year":"2021","journal-title":"JAMA Dermatol."},{"key":"2025020609283486800_r5","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1529-8019.2007.00140.x","article-title":"Alefacept for the treatment of psoriasis and other dermatologic diseases","volume":"20","author":"Strober","year":"2007","journal-title":"Dermatol. 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