{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T12:52:01Z","timestamp":1745931121610,"version":"3.37.3"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030B_201273"],"award-info":[{"award-number":["310030B_201273"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Hans Buss Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The importance of unconventional T cells for mucosal immunity is firmly established but for systemic bacterial infection remains less well defined. In this study, we explored the role of various T cell subsets in murine Bartonella infection, which establishes persistent bacteremia unless controlled by antibacterial Abs. We found that \u03b1\u03b2 T cells are essential for Ab production against and clearance of B. taylorii, whereas MHC class I (MHC-I)- or MHC class II (MHC-II)-deficient mice eliminated B. taylorii infection with normal kinetics. Similarly, animals lacking either CD1d or MR1 suppressed bacteremia with normal kinetics. Interestingly, mice with a combined deficiency of either MHC-II and CD1d or MHC-II and MR1 failed to clear the infection, indicating that the combination of CD1d- and MR1-restricted T cells can compensate for the lack of MHC-II in this model. Our data document a previously underappreciated contribution of unconventional T cells to the control of systemic bacterial infection, supposedly as helper cells for antibacterial Ab production.<\/jats:p>","DOI":"10.4049\/jimmunol.2400045","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T13:20:27Z","timestamp":1720617627000},"page":"553-558","source":"Crossref","is-referenced-by-count":1,"title":["Cutting Edge: Redundant Roles for MHC Class II\u2013, CD1d-, and MR1-restricted T Cells in Clearing <i>Bartonella<\/i> Infection"],"prefix":"10.1093","volume":"213","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3808-3377","authenticated-orcid":false,"given":"Lena K","family":"Siewert","sequence":"first","affiliation":[{"name":"Biozentrum, University of Basel , Basel ,","place":["Switzerland"]},{"name":"Division of Experimental Virology, Department Biomedicine\u2013Haus Petersplatz, University of Basel , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Fromm","sequence":"additional","affiliation":[{"name":"Biozentrum, University of Basel , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Dehio","sequence":"additional","affiliation":[{"name":"Biozentrum, University of Basel , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1594-3189","authenticated-orcid":false,"given":"Daniel D","family":"Pinschewer","sequence":"additional","affiliation":[{"name":"Division of Experimental Virology, Department Biomedicine\u2013Haus Petersplatz, University of Basel , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"2025012305135199000_r1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1146\/annurev-immunol-093019-112348","article-title":"Control of immunity by the microbiota","volume":"39","author":"Ansaldo","year":"2021","journal-title":"Annu. 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