{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:38:01Z","timestamp":1792546681515,"version":"4.5.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["AG020719"],"award-info":[{"award-number":["AG020719"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"Bowman Professorship in Medical Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>CMV drives the accumulation of virus-specific, highly differentiated CD8 memory T cells (memory inflation [MI]). In mice, MI was shown to directly correlate with the CMV infection dose, yet the CMV-associated CD8 MI plateaus over time. It is unclear how MI is regulated with aging. We infected young mice with 102, 104, and 106 PFU of murine CMV and confirmed that MI magnitude was directly proportional to the infectious dose, reaching a setpoint by midlife. By old age, MI subsided, most prominently in mice infected with 106 PFU, and reached statistical parity between groups in 26-mo-old mice. This corresponded to an age-related loss in lymphatic endothelial cells in lymph nodes, recently shown to be sufficient to drive MI in mice. We propose that MI size and persistence over the lifespan is controlled by the size of the lymphatic endothelial cell niche, whose shrinking leads to reduced MI with aging.<\/jats:p>","DOI":"10.4049\/jimmunol.2400113","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T12:50:04Z","timestamp":1723812604000},"page":"965-970","source":"Crossref","is-referenced-by-count":2,"title":["Late-life Attenuation of Cytomegalovirus-mediated CD8 T Cell Memory Inflation: Shrinking of the Cytomegalovirus Latency Niche"],"prefix":"10.1093","volume":"213","author":[{"given":"Christopher P","family":"Coplen","sequence":"first","affiliation":[{"name":"Department of Immunobiology, University of Arizona College of Medicine\u2013Tucson , Tucson, AZ"},{"name":"University of Arizona Center on Aging, University of Arizona College of Medicine\u2013Tucson , Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandip Ashok","family":"Sonar","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, University of Arizona College of Medicine\u2013Tucson , Tucson, AZ"},{"name":"University of Arizona Center on Aging, University of Arizona College of Medicine\u2013Tucson , Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5830-5323","authenticated-orcid":false,"given":"Janko \u017d","family":"Nikolich","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, University of Arizona College of Medicine\u2013Tucson , Tucson, AZ"},{"name":"University of Arizona Center on Aging, University of Arizona College of Medicine\u2013Tucson , Tucson, AZ"},{"name":"Aegis Consortium for Pandemic-Free Future, University of Arizona Health Sciences , Tucson, AZ"},{"name":"BIO5 Institute, University of Arizona , Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"2025012305162563400_r1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/ni804","article-title":"Programmed contraction of CD8+ T cells after infection","volume":"3","author":"Badovinac","year":"2002","journal-title":"Nat. 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