{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T11:32:14Z","timestamp":1776684734324,"version":"3.51.2"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100011684","name":"Crohn''''s and Colitis Foundation","doi-asserted-by":"publisher","award":["409992"],"award-info":[{"award-number":["409992"]}],"id":[{"id":"10.13039\/100011684","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK111856"],"award-info":[{"award-number":["R01DK111856"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["17\/FRL\/4863"],"award-info":[{"award-number":["17\/FRL\/4863"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["18\/FRL\/6201"],"award-info":[{"award-number":["18\/FRL\/6201"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Aberrant intestinal inflammation plays a critical role in the development of colitis-associated colorectal cancer (CAC), yet the mechanisms controlling tumor development by the myeloid immune compartment are not fully understood. Although altered microRNA expression is observed in CAC, it is also unclear how myeloid-specific microRNAs impact the inflammatory process that underpins the continuum from ulcerative colitis to tumorigenesis. In this study, we report that miR-223 acts to limit myeloid-driven inflammation in the azoxymethane (AOM)\u2013dextran sodium sulfate (DSS) model of CAC in mice. In this model, miR-223\u2013\/y mice present with significantly larger tumors with an enhanced proliferative signature. Immunoprofiling showed that miR-223\u2013\/y mice have significantly increased colonic myeloid immune infiltrate (neutrophils, monocytes, and macrophages) following AOM-DSS. This was accompanied by an increased inflammatory chemokine and cytokine signature for monocytes and neutrophils. Bone marrow chimera studies demonstrate that myeloid-expressed miR-223 is responsible for the enhanced tumor proliferation and inflammatory response. RNA sequencing identified several pathways that could be contributing to the development of CAC in miR-223\u2013\/y mice, including the IL-6\/IL-17a cytokine family and STAT3 signaling. Lastly, neutrophil depletion with an anti-GR1 Ab (Ly6G\/Ly6C) during the initial phase of the AOM-DSS model reduced the tumor burden in miR-223\u2013\/y mice. Collectively, our data indicate that miR-223 is an important regulator of mucosal inflammation and acts to constrain the progression from ulcerative colitis to CAC by limiting myeloid-associated inflammation.<\/jats:p>","DOI":"10.4049\/jimmunol.2400129","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T12:41:46Z","timestamp":1730464906000},"page":"1869-1883","source":"Crossref","is-referenced-by-count":1,"title":["The MicroRNA <i>miR-223<\/i> Constrains Colitis-associated Tumorigenesis by Limiting Myeloid Cell Infiltration and Chemokine Expression"],"prefix":"10.1093","volume":"213","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7319-086X","authenticated-orcid":false,"given":"Ciara L","family":"Flynn","sequence":"first","affiliation":[{"name":"Mucosal Immunology Research Laboratory, Kathleen Lonsdale Institute for Human Health Research, Department of Biology, Maynooth University , Maynooth ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0698-3824","authenticated-orcid":false,"given":"Gary E","family":"Markey","sequence":"additional","affiliation":[{"name":"Allergy, Inflammation & Remodelling Research Laboratory, Kathleen Lonsdale Institute for Human Health Research, Department of Biology, Maynooth University , Maynooth ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3021-5523","authenticated-orcid":false,"given":"Viola","family":"Neudecker","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Columbia University Medical Center , New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3307-430X","authenticated-orcid":false,"given":"Charlotte","family":"Farrelly","sequence":"additional","affiliation":[{"name":"Mucosal Immunology Research Laboratory, Kathleen Lonsdale Institute for Human Health Research, Department of Biology, Maynooth University , Maynooth ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3262-3571","authenticated-orcid":false,"given":"Glenn T","family":"Furuta","sequence":"additional","affiliation":[{"name":"Gastrointestinal Eosinophilic Diseases Program, Digestive Health Institute, Children\u2019s Hospital Colorado, Department of Paediatrics, University of Colorado School of Medicine , Aurora, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger K","family":"Eltzschig","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Critical Care and Pain Medicine, McGovern Medical School, University of Texas Health Science Center at Houston , Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne C","family":"Masterson","sequence":"additional","affiliation":[{"name":"Allergy, Inflammation & Remodelling Research Laboratory, Kathleen Lonsdale Institute for Human Health Research, Department of Biology, Maynooth University , Maynooth ,","place":["Ireland"]},{"name":"Gastrointestinal Eosinophilic Diseases Program, Digestive Health Institute, Children\u2019s Hospital Colorado, Department of Paediatrics, University of Colorado School of Medicine , Aurora, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3331-3148","authenticated-orcid":false,"given":"E\u00f3in N","family":"McNamee","sequence":"additional","affiliation":[{"name":"Mucosal Immunology Research Laboratory, Kathleen Lonsdale Institute for Human Health Research, Department of Biology, Maynooth University , Maynooth ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,11,1]]},"reference":[{"key":"2025020609304306200_r1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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