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Using IFN-\u03b3\u2212\/\u2212 T cell chimeric mice and adoptive transfer of IFN-\u03b3\u2212\/\u2212 T cells into TCR\u03b2\u2212\/\u2212\u03b4\u2212\/\u2212 mice, we demonstrate that control of lung Mtb burden is in fact dependent on T cell\u2013derived IFN-\u03b3, and, furthermore, mice selectively deficient in T cell\u2013derived IFN-\u03b3 develop exacerbated disease compared with T cell\u2013deficient control animals, despite equivalent lung bacterial burdens. Deficiency in T cell\u2013derived IFN-\u03b3 skews infected and bystander monocyte-derived macrophages to an alternative M2 phenotype and promotes neutrophil and eosinophil influx. Our studies support an important role for T cell\u2013derived IFN-\u03b3 in pulmonary immunity against tuberculosis.<\/jats:p>","DOI":"10.4049\/jimmunol.2400145","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T13:05:44Z","timestamp":1719234344000},"page":"339-346","source":"Crossref","is-referenced-by-count":18,"title":["Reappraising the Role of T Cell\u2013Derived IFN-\u03b3 in Restriction of <i>Mycobacterium tuberculosis<\/i> in the Murine Lung"],"prefix":"10.1093","volume":"213","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0803-4312","authenticated-orcid":false,"given":"Karolina","family":"Maciag","sequence":"first","affiliation":[{"name":"Division of Allergy and Infectious Diseases, University of Washington , Seattle, WA"},{"name":"Seattle Children\u2019s Research Institute , Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7142-4394","authenticated-orcid":false,"given":"Courtney R","family":"Plumlee","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute , Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7850-3498","authenticated-orcid":false,"given":"Sara B","family":"Cohen","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute , Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0142-5970","authenticated-orcid":false,"given":"Benjamin H","family":"Gern","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute , Seattle, WA"},{"name":"Department of Pediatrics, University of Washington , Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0088-1066","authenticated-orcid":false,"given":"Kevin B","family":"Urdahl","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute , Seattle, WA"},{"name":"Department of Pediatrics, University of Washington , Seattle, WA"},{"name":"Department of Immunology, University of Washington , Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"2025012305123050500_r1","doi-asserted-by":"crossref","first-page":"5407","DOI":"10.4049\/jimmunol.162.9.5407","article-title":"Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis","volume":"162","author":"Caruso","year":"1999","journal-title":"J. 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