{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:18:25Z","timestamp":1779909505044,"version":"3.53.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI142382"],"award-info":[{"award-number":["R21AI142382"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI105265"],"award-info":[{"award-number":["R01AI105265"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI110613"],"award-info":[{"award-number":["R01AI110613"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The most common congenital viral infection is CMV, which leads to numerous neurologic disabilities. Using a mouse model of congenital CMV, we previously determined that Ag-specific CD8+ T cells traffic to the brain in a CCR9-dependent manner. The mechanism by which these CD8+ T cells acquire a CCR9-dependent \u201cbrain-tropic\u201d phenotype remains unclear. In this study, we identify the key factor that imprints brain homing specificity on CD8+ T cells, the source of production, and the location where CCR9 expression is induced. Specifically, we discovered that CCR9 is induced on CD8+ T cells by retinoic acid\u2013producing CD8\u03b1+ dendritic cells in the cervical lymph node postinfection. We found that retinoic acid is important for CD8+ T cells to establish tissue residency in the brain. Collectively, our data expand the role of retinoic acid during infection and mechanistically demonstrate how CD8+ T cells are primed to protect the brain during congenital viral infection.<\/jats:p>","DOI":"10.4049\/jimmunol.2400150","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T12:54:01Z","timestamp":1723467241000},"page":"933-939","source":"Crossref","is-referenced-by-count":4,"title":["Cutting Edge: Retinoic Acid Promotes Brain-homing of CD8+ T Cells during Congenital Cytomegalovirus Infection"],"prefix":"10.1093","volume":"213","author":[{"given":"Zachary T","family":"Hilt","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1988-7196","authenticated-orcid":false,"given":"Wisler","family":"Charles","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taha","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey V","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shide","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3445-7570","authenticated-orcid":false,"given":"Samantha P","family":"Wesnak","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7495-7660","authenticated-orcid":false,"given":"Norah L","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D","family":"Rudd","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Cornell University , Ithaca, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"2025012305162228400_r1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1128\/CMR.00062-12","article-title":"The \u201csilent\u201d global burden of congenital cytomegalovirus","volume":"26","author":"Manicklal","year":"2013","journal-title":"Clin. 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