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Leukemogenesis, but not the developmental block, depends on TCF-1, \u03b2-catenin\u2019s DNA-binding partner. In this study, we show that \u03b2-catenin activation directs the DNA-binding protein HEB to block DP thymocyte development. Conditional loss of HEB in DP thymocytes with stabilized \u03b2-catenin restores the frequencies of postselection TCR\u03b2hi\/CCR7+ and TCR\u03b2hi\/CD69+ DPs and their cell-cycle profile. This recovery is associated with significant reversal of \u03b2-catenin-induced expression changes, particularly those related to the CD69+ DP cell signature and to cell-cycle pathways. Stabilizing \u03b2-catenin in DP thymocytes directs HEB binding to \u224811,000 novel DNA sites throughout the genome. Novel HEB sites mark most CD69+ DP cell signature genes that change expression upon activation of \u03b2-catenin and then revert after loss of HEB. Moreover, many of the novel HEB sites occupy promoter regions of genes enriched in mitotic cell cycle pathways. HEB binding to those regions correlates with downregulation of the associated genes, and HEB inactivation restores expression to physiologic levels. These findings highlight a molecular interplay between HEB and \u03b2-catenin that can impair thymic development.<\/jats:p>","DOI":"10.4049\/jimmunol.2400160","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T08:31:31Z","timestamp":1719995491000},"page":"641-650","source":"Crossref","is-referenced-by-count":1,"title":["Stabilization of \u03b2-Catenin Directs HEB to Limit Thymic Selection"],"prefix":"10.1093","volume":"213","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2272-6403","authenticated-orcid":false,"given":"Georgios","family":"Tousinas","sequence":"first","affiliation":[{"name":"Department of Immunology, Mayo Clinic , Scottsdale, AZ"},{"name":"Laboratory of Biological Chemistry, Medical Department, School of Health Sciences, University of Ioannina , Ioannina ,","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0118-7818","authenticated-orcid":false,"given":"Akinola","family":"Olumide Emmanuel","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Chicago , Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Tracy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Einstein College of Medicine , Bronx, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Arnovitz","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Chicago , Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Immunology, Mayo Clinic , Scottsdale, AZ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7642-8157","authenticated-orcid":false,"given":"Thomais","family":"Papamarcaki","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Chemistry, Medical Department, School of Health Sciences, University of Ioannina , Ioannina ,","place":["Greece"]},{"name":"Biomedical Research Institute, Foundation for Research and Technology-Hellas , Ioannina ,","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2936-066X","authenticated-orcid":false,"given":"Fotini","family":"Gounari","sequence":"additional","affiliation":[{"name":"Department of Immunology, Mayo Clinic , Scottsdale, AZ"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"2025100802364597700_r1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41392-021-00762-6","article-title":"Wnt\/\u03b2-catenin signalling: function, biological mechanisms, and therapeutic opportunities","volume":"7","author":"Liu","year":"2022","journal-title":"Signal. 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