{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T02:31:25Z","timestamp":1785724285949,"version":"3.56.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Government | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-173470"],"award-info":[{"award-number":["PJT-173470"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Government | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-156222"],"award-info":[{"award-number":["PJT-156222"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pre-eclampsia (PE) affects 5\u20138% of pregnancies and has detrimental effects on maternal\u2013fetal health. PE is characterized by de novo hypertension after 20 wk of gestation and end-organ damage. Systemic inflammatory imbalance has been associated with PE, but its contribution to the pathology is poorly understood. Our objective was to investigate maternal systemic immune changes in early-onset PE (EOPE) and late-onset PE (LOPE) versus uncomplicated pregnancies (control [CTRL]), and their contribution to endothelial activation, hallmark of hypertension. Blood samples were analyzed by flow cytometry, multiplex assay, intracellular cytokine staining, and single-cell RNA sequencing. We performed cocultures between circulating immune cells and HUVECs to assess endothelial activation. We found that EOPE had decreased regulatory T cells (4.64\u00b10.33, p\u2009&amp;lt;\u20090.05) and monocytes (33.92\u00b13.08, p\u2009&amp;lt;\u20090.01), whereas LOPE had decreased regulatory T cells (4.60\u00b10.30, p\u2009&amp;lt;\u20090.05) and Th2 cells (7.50\u00b10.62, p\u2009&amp;lt;\u20090.01) versus CTRL. Compared to CTRL, elevated cytokines\/chemokines, and growth factors were observed in LOPE, whereas EOPE primarily showed decreased levels. Using intracellular cytokine staining, we observed more monocytes producing IL-12, TNF-\u03b1, and IL-1\u03b2 (all p\u2009&amp;lt;\u20090.05) in LOPE versus CTRL. At the transcriptomic level, we found differentially expressed genes between EOPE and CTRL, predominantly related to upregulation of immune activation pathways. Lastly, EOPE PBMCs induced heightened endothelial activation in vitro observed by increased ICAM-1 and ET-1 (p\u2009&amp;lt;\u20090.05), whereas LOPE PBMCs required LPS stimulation. Although significant proteomic changes are observed in the LOPE group, the EOPE displayed changes mostly at the transcriptomic levels and could induce endothelial activation in vitro.<\/jats:p>","DOI":"10.4049\/jimmunol.2400196","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T12:43:17Z","timestamp":1726836197000},"page":"1292-1304","source":"Crossref","is-referenced-by-count":15,"title":["Circulating Immune Cells from Early- and Late-onset Pre-eclampsia Displays Distinct Profiles with Differential Impact on Endothelial Activation"],"prefix":"10.1093","volume":"213","author":[{"given":"Elsa","family":"Bernier","sequence":"first","affiliation":[{"name":"Sainte-Justine Hospital Research Center , Montreal, Quebec ,","place":["Canada"]},{"name":"Department of Microbiology and Immunology, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3365-509X","authenticated-orcid":false,"given":"Camille","family":"Couture","sequence":"additional","affiliation":[{"name":"Sainte-Justine Hospital Research Center , Montreal, Quebec ,","place":["Canada"]},{"name":"Department of Microbiology and Immunology, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9783-6641","authenticated-orcid":false,"given":"Anna","family":"Borchers","sequence":"additional","affiliation":[{"name":"Mayo Clinic Graduate School of Biomedical Sciences , Rochester, MN"},{"name":"Department of Immunology, Mayo Clinic , Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0843-0625","authenticated-orcid":false,"given":"Marie-Eve","family":"Brien","sequence":"additional","affiliation":[{"name":"Sainte-Justine Hospital Research Center , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7014-8639","authenticated-orcid":false,"given":"Charles H","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Molecular Sciences, Queen\u2019s University , Kingston, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5164-5816","authenticated-orcid":false,"given":"Sylvie","family":"Girard","sequence":"additional","affiliation":[{"name":"Department of Immunology, Mayo Clinic , Rochester, MN"},{"name":"Department of Obstetrics and Gynecology, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec ,","place":["Canada"]},{"name":"Department of Obstetrics and Gynecology, Mayo Clinic , Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,20]]},"reference":[{"key":"2025020609281169900_r1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.preghy.2021.09.008","article-title":"The 2021 International Society for the Study of Hypertension in Pregnancy classification, diagnosis & management recommendations for international practice","volume":"27","author":"Magee","year":"2022","journal-title":"Pregnancy Hypertens."},{"key":"2025020609281169900_r2","first-page":"e31143","article-title":"Preeclampsia incidence and its maternal and neonatal outcomes with associated risk factors","volume":"14","author":"Khan","year":"2022","journal-title":"Cureus"},{"key":"2025020609281169900_r3","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1161\/HYPERTENSIONAHA.123.21061","article-title":"Long-term impacts of preeclampsia on the cardiovascular system of mother and offspring","volume":"80","author":"Yang","year":"2023","journal-title":"Hypertension"},{"key":"2025020609281169900_r4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1081\/PRG-120021060","article-title":"Subclassification of preeclampsia","volume":"22","author":"von Dadelszen","year":"2003","journal-title":"Hypertens. 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