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Previously, we observed increased vulnerability to bacterial (Staphylococcus aureus) endophthalmitis in global AMPK\u03b11 knockout mice. In this study, we investigated the specific involvement of AMPK\u03b11 in myeloid cells using LysMCre;AMPK\u03b11fl mice. Our findings revealed that whereas endophthalmitis resolved in wild-type C57BL\/6 mice, the severity of the disease progressively worsened in AMPK\u03b11-deficient mice over time. Moreover, the intraocular bacterial load and inflammatory mediators (e.g., IL-1\u03b2, TNF-\u03b1, IL-6, and CXCL2) were markedly elevated in the LysMCre;AMPK\u03b11fl mice. Mechanistically, the deletion of AMPK\u03b11 in myeloid cells skewed macrophage polarization toward the inflammatory M1 phenotype and impaired the phagocytic clearance of S. aureus by macrophages. Notably, transferring AMPK-competent bone marrow from wild-type mice to AMPK\u03b11 knockout mice preserved retinal function and mitigated the severity of endophthalmitis. Overall, our study underscores the role of myeloid-specific AMPK\u03b11 in promoting the resolution of inflammation in the eye during bacterial infection. Hence, therapeutic strategies aimed at restoring or enhancing AMPK\u03b11 activity could improve visual outcomes in endophthalmitis and other ocular infections.<\/jats:p>","DOI":"10.4049\/jimmunol.2400282","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T16:39:14Z","timestamp":1729096754000},"page":"1656-1665","source":"Crossref","is-referenced-by-count":3,"title":["Myeloid Cell\u2013Specific Deletion of AMPK\u03b11 Worsens Ocular Bacterial Infection by Skewing Macrophage Phenotypes"],"prefix":"10.1093","volume":"213","author":[{"given":"Sukhvinder","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomical Sciences, Kresge Eye Institute, Wayne State University School of Medicine , Detroit, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5517-1120","authenticated-orcid":false,"given":"Pawan Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Mason Eye Institute, University of Missouri School of Medicine , Columbia, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeeshan","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomical Sciences, Kresge Eye Institute, Wayne State University School of Medicine , Detroit, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susmita","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomical Sciences, Kresge Eye Institute, Wayne State University School of Medicine , Detroit, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7017-9032","authenticated-orcid":false,"given":"Marc","family":"Foretz","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, INSERM, Institut Cochin , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0121-0224","authenticated-orcid":false,"given":"Benoit","family":"Viollet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, INSERM, Institut Cochin , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7123-829X","authenticated-orcid":false,"given":"Shailendra","family":"Giri","sequence":"additional","affiliation":[{"name":"Department of Neurology, Henry Ford Health System , Detroit, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomical Sciences, Kresge Eye Institute, Wayne State University School of Medicine , Detroit, MI"},{"name":"Department of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine , Detroit, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"key":"2025020609293806800_r1","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1111\/cmi.12625","article-title":"5-Aminoimidazole-4-carboxamide ribonucleoside-mediated adenosine monophosphate-activated protein kinase activation induces protective innate responses in bacterial endophthalmitis","volume":"18","author":"Kumar","year":"2016","journal-title":"Cell. 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