{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:39:00Z","timestamp":1792028340003,"version":"4.4.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI162678"],"award-info":[{"award-number":["AI162678"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR077518"],"award-info":[{"award-number":["AR077518"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["CA225680"],"award-info":[{"award-number":["CA225680"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>B cell activation is accompanied by dynamic metabolic reprogramming, supported by a multitude of nutrients that include glucose, amino acids, and fatty acids. Although several studies have indicated that fatty acid mitochondrial oxidation is critical for immune cell functions, contradictory findings have been reported. Carnitine palmitoyltransferase II (CPT2) is a critical enzyme for long-chain fatty acid oxidation in mitochondria. In this study, we test the requirement of CPT2 for humoral immunity using a mouse model with a lymphocyte-specific deletion of CPT2. Stable [13C] isotope tracing reveals highly reduced fatty acid\u2013derived citrate production in CPT2-deficient B cells. Yet, CPT2 deficiency has no significant impact on B cell development, B cell activation, germinal center formation, and Ab production upon either thymus-dependent or -independent Ag challenges. Together, our findings indicate that CPT2-mediated fatty acid oxidation is dispensable for humoral immunity, highlighting the metabolic flexibility of lymphocytes.<\/jats:p>","DOI":"10.4049\/jimmunol.2400285","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T08:38:19Z","timestamp":1726043899000},"page":"1139-1149","source":"Crossref","is-referenced-by-count":17,"title":["CPT2-mediated Fatty Acid Oxidation Is Dispensable for Humoral Immunity"],"prefix":"10.1093","volume":"213","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3739-5643","authenticated-orcid":false,"given":"Meilu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital of Harbin Medical University , Harbin ,","place":["People\u2019s Republic of China"]},{"name":"Division of Rheumatology, Department of Medicine, Mayo Clinic , Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Mayo Clinic , Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Mayo Clinic , Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8411-319X","authenticated-orcid":false,"given":"Xingxing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Mayo Clinic , Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital of Harbin Medical University , Harbin ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2898-6831","authenticated-orcid":false,"given":"Taro","family":"Hitosugi","sequence":"additional","affiliation":[{"name":"Department of Oncology, Mayo Clinic , Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9909-7732","authenticated-orcid":false,"given":"Hu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Mayo Clinic , Rochester, MN"},{"name":"Department of Immunology, Mayo Clinic , Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"2025020609275104500_r1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/imr.12754","article-title":"The continuing story of T-cell independent antibodies","volume":"288","author":"Allman","year":"2019","journal-title":"Immunol. 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