{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:01:25Z","timestamp":1784894485936,"version":"3.55.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI149787"],"award-info":[{"award-number":["AI149787"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DC018496"],"award-info":[{"award-number":["DC018496"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI156293"],"award-info":[{"award-number":["AI156293"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI159347"],"award-info":[{"award-number":["AI159347"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI139449"],"award-info":[{"award-number":["AI139449"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The increased susceptibility of infants and young children to some diseases has often been explained as the neonatal immune system (NIS) being incomplete and\/or underdeveloped. However, our recent work demonstrated that neonatal mice could clear a Bordetella pertussis (Bp) strain lacking pertussis toxin (PTx) (Bp\u0394ptx) much more efficiently than adult mice, indicating that the NIS can be extremely effective, but this ability is highly sensitive to being blocked by PTx. In this article, we investigated immunological mechanisms by which neonates efficiently and rapidly clear Bp\u0394ptx to better understand how the NIS functions and how PTx disrupts it. Depleting neutrophils, or blocking their recruitment, inhibited pups\u2019 ability to rapidly clear Bp\u0394ptx, revealing a critical role for neutrophils. Pups deficient in complement (C3\u2212\/\u2212) failed to recruit neutrophils and did not efficiently clear Bp\u0394ptx but recovered these abilities upon treatment with C3a. Neutrophil depletion in C3\u2212\/\u2212 pups led to further failure to control Bp\u0394ptx, suggesting that neutrophils and complement have independent roles in rapid clearance of Bp\u0394ptx. Depleting or disrupting neutrophils and complement had negligible effect on the rapid growth of wild-type Bp, indicating that PTx blocks these otherwise highly effective aspects of the NIS.<\/jats:p>","DOI":"10.4049\/jimmunol.2400363","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T08:53:31Z","timestamp":1730278411000},"page":"1825-1833","source":"Crossref","is-referenced-by-count":5,"title":["Neonatal Neutrophil-mediated Control of\n                    <i>Bordetella pertussis<\/i>\n                    Is Disrupted by Pertussis Toxin"],"prefix":"10.1093","volume":"213","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2895-0441","authenticated-orcid":false,"given":"Colleen J","family":"Sedney","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia , Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5131-7900","authenticated-orcid":false,"given":"Jillian","family":"Masters","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia , Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiya","family":"Callender","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia , Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9847-0286","authenticated-orcid":false,"given":"Kalyan","family":"Dewan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia , Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1997-4302","authenticated-orcid":false,"given":"Amanda","family":"Caulfield","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia , Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8893-2133","authenticated-orcid":false,"given":"Eric T","family":"Harvill","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia , Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"2026072407090709700_r1","article-title":"Pertussis: vaccine preventable diseases surveillance standards","author":"World Health Organization","year":"2018"},{"key":"2026072407090709700_r2","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/cid\/ciy889","article-title":"Severe pertussis infections in the United States, 2011\u20132015","volume":"69","author":"Mbayei","year":"2019","journal-title":"Clin. 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