{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:53:19Z","timestamp":1787226799630,"version":"build-2736575974"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This Pillars of Immunology article is a commentary on \u201cTh17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis,\u201d a pivotal article written by H. R. Conti, F. Shen, N. Nayyar, E. Stocum, J. N. Sun, M. J. Lindemann, A. W. Ho, J. H. Hai, J. J . Yu, J. W. Jung, S. G. Filler, P. Masso-Welch, M. Edgerton, and S. L. Gaffen, and published in The Journal of Experimental Medicine in 2009. https:\/\/doi.org\/10.1084\/jem.20081463.<\/jats:p>","DOI":"10.4049\/jimmunol.2400510","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T20:00:16Z","timestamp":1728331216000},"page":"1049-1051","source":"Crossref","is-referenced-by-count":6,"title":["IL-17: A Critical Cytokine for Defense against Oral Candidiasis"],"prefix":"10.1093","volume":"213","author":[{"given":"Lucas","family":"dos Santos Dias","sequence":"first","affiliation":[{"name":"Fungal Pathogenesis Section, Laboratory of Clinical Immunology & Microbiology (LCIM), National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4994-9500","authenticated-orcid":false,"given":"Michail S","family":"Lionakis","sequence":"additional","affiliation":[{"name":"Fungal Pathogenesis Section, Laboratory of Clinical Immunology & Microbiology (LCIM), National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,15]]},"reference":[{"key":"2025020609280491500_r1","doi-asserted-by":"crossref","first-page":"5445","DOI":"10.4049\/jimmunol.150.12.5445","article-title":"CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene","volume":"150","author":"Rouvier","year":"1993","journal-title":"J. Immunol."},{"key":"2025020609280491500_r2","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/1074-7613(95)90070-5","article-title":"Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor","volume":"3","author":"Yao","year":"1995","journal-title":"Immunity"},{"key":"2025020609280491500_r3","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1084\/jem.194.4.519","article-title":"Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense","volume":"194","author":"Ye","year":"2001","journal-title":"J. Exp. Med."},{"key":"2025020609280491500_r4","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4049\/jimmunol.175.1.404","article-title":"Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis","volume":"175","author":"McAllister","year":"2005","journal-title":"J. Immunol."},{"key":"2025020609280491500_r5","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1074\/jbc.M207577200","article-title":"Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17","volume":"278","author":"Aggarwal","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2025020609280491500_r6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1084\/jem.20041257","article-title":"IL-23 drives a pathogenic T cell population that induces autoimmune inflammation","volume":"201","author":"Langrish","year":"2005","journal-title":"J. Exp. Med."},{"key":"2025020609280491500_r7","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","article-title":"Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"Harrington","year":"2005","journal-title":"Nat. Immunol."},{"key":"2025020609280491500_r8","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ni1261","article-title":"A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17","volume":"6","author":"Park","year":"2005","journal-title":"Nat. Immunol."},{"key":"2025020609280491500_r9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells","volume":"441","author":"Bettelli","year":"2006","journal-title":"Nature"},{"key":"2025020609280491500_r10","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature04754","article-title":"Transforming growth factor-beta induces development of the TH17 lineage","volume":"441","author":"Mangan","year":"2006","journal-title":"Nature"},{"key":"2025020609280491500_r11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.immuni.2006.01.001","article-title":"TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells","volume":"24","author":"Veldhoen","year":"2006","journal-title":"Immunity"},{"key":"2025020609280491500_r12","doi-asserted-by":"crossref","first-page":"4662","DOI":"10.4049\/jimmunol.177.7.4662","article-title":"IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection","volume":"177","author":"Lockhart","year":"2006","journal-title":"J. Immunol."},{"key":"2025020609280491500_r13","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41577-022-00826-w","article-title":"Immune responses to human fungal pathogens and therapeutic prospects","volume":"23","author":"Lionakis","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"2025020609280491500_r14","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1399-302X.2006.00288.x","article-title":"Distinct roles for interleukin-12p40 and tumour necrosis factor in resistance to oral candidiasis defined by gene-targeting","volume":"21","author":"Farah","year":"2006","journal-title":"Oral Microbiol. Immunol."},{"key":"2025020609280491500_r15","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/ni1467","article-title":"Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells","volume":"8","author":"Acosta-Rodriguez","year":"2007","journal-title":"Nat. Immunol."},{"key":"2025020609280491500_r16","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/ni1460","article-title":"Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17","volume":"8","author":"LeibundGut-Landmann","year":"2007","journal-title":"Nat. Immunol."},{"key":"2025020609280491500_r17","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1038\/jid.2008.139","article-title":"Patients with chronic mucocutaneous candidiasis exhibit reduced production of Th17-associated cytokines IL-17 and IL-22","volume":"128","author":"Eyerich","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"2025020609280491500_r18","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1084\/jem.20081463","article-title":"Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis","volume":"206","author":"Conti","year":"2009","journal-title":"J. Exp. Med."},{"key":"2025020609280491500_r19","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.immuni.2013.09.002","article-title":"An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis","volume":"39","author":"Boisson","year":"2013","journal-title":"Immunity"},{"key":"2025020609280491500_r20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1126\/science.1200439","article-title":"Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity","volume":"332","author":"Puel","year":"2011","journal-title":"Science"},{"key":"2025020609280491500_r21","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1084\/jem.20141065","article-title":"Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis","volume":"212","author":"Ling","year":"2015","journal-title":"J. Exp. Med."},{"key":"2025020609280491500_r22","doi-asserted-by":"crossref","first-page":"100266","DOI":"10.1016\/j.lanepe.2021.100266","article-title":"Risk of candidiasis associated with interleukin-17 inhibitors: a real-world observational study of multiple independent sources","volume":"13","author":"Davidson","year":"2022","journal-title":"Lancet Reg. Health Eur."},{"key":"2025020609280491500_r23","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/mi.2012.128","article-title":"Th17 cells confer long-term adaptive immunity to oral mucosal Candida albicans infections","volume":"6","author":"Hernandez-Santos","year":"2013","journal-title":"Mucosal Immunol."},{"key":"2025020609280491500_r24","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1084\/jem.20130877","article-title":"Oral-resident natural Th17 cells and gammadelta T cells control opportunistic Candida albicans infections","volume":"211","author":"Conti","year":"2014","journal-title":"J. Exp. Med."},{"key":"2025020609280491500_r25","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1056\/NEJMoa2202348","article-title":"Reappraisal of idiopathic CD4 lymphocytopenia at 30 years","volume":"388","author":"Lisco","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"2025020609280491500_r26","doi-asserted-by":"crossref","first-page":"e20231044","DOI":"10.1084\/jem.20231044","article-title":"Helper T cell immunity in humans with inherited CD4 deficiency","volume":"221","author":"Guerin","year":"2024","journal-title":"J. Exp. Med."},{"key":"2025020609280491500_r27","doi-asserted-by":"crossref","first-page":"eaba0570","DOI":"10.1126\/sciimmunol.aba0570","article-title":"Oral epithelial IL-22\/STAT3 signaling licenses IL-17-mediated immunity to oral mucosal candidiasis","volume":"5","author":"Aggor","year":"2020","journal-title":"Sci. Immunol."},{"key":"2025020609280491500_r28","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature17625","article-title":"Candidalysin is a fungal peptide toxin critical for mucosal infection","volume":"532","author":"Moyes","year":"2016","journal-title":"Nature"},{"key":"2025020609280491500_r29","doi-asserted-by":"crossref","first-page":"eaam8834","DOI":"10.1126\/sciimmunol.aam8834","article-title":"Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin","volume":"2","author":"Verma","year":"2017","journal-title":"Sci. Immunol."},{"key":"2025020609280491500_r30","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.mucimm.2024.01.003","article-title":"Immunity to pathogenic mucosal C. albicans infections mediated by oral megakaryocytes activated by IL-17 and candidalysin","volume":"17","author":"Launder","year":"2024","journal-title":"Mucosal Immunol."},{"key":"2025020609280491500_r31","doi-asserted-by":"crossref","first-page":"e1005882","DOI":"10.1371\/journal.ppat.1005882","article-title":"IL-1 coordinates the neutrophil response to C. albicans in the oral mucosa","volume":"12","author":"Altmeier","year":"2016","journal-title":"PLoS Pathog."},{"key":"2025020609280491500_r32","doi-asserted-by":"crossref","first-page":"e1007069","DOI":"10.1371\/journal.ppat.1007069","article-title":"Langerin+ DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection","volume":"14","author":"Sparber","year":"2018","journal-title":"PLoS Pathog."},{"key":"2025020609280491500_r33","doi-asserted-by":"crossref","first-page":"e160348","DOI":"10.1172\/jci.insight.160348","article-title":"A gut-oral microbiome-driven axis controls oropharyngeal candidiasis through retinoic acid","volume":"7","author":"Aggor","year":"2022","journal-title":"JCI Insight"},{"key":"2025020609280491500_r34","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.chom.2023.08.016","article-title":"IkappaBzeta is an essential mediator of immunity to oropharyngeal candidiasis","volume":"31","author":"Taylor","year":"2023","journal-title":"Cell Host Microbe"},{"key":"2025020609280491500_r35","doi-asserted-by":"crossref","first-page":"e1012302","DOI":"10.1371\/journal.ppat.1012302","article-title":"Combinatorial actions of IL-22 and IL-17 drive optimal immunity to oral candidiasis through SPRRs","volume":"20","author":"Aggor","year":"2024","journal-title":"PLoS Pathog."},{"key":"2025020609280491500_r36","doi-asserted-by":"crossref","first-page":"627","DOI":"10.4049\/jimmunol.1800515","article-title":"IL-36 and IL-1\/IL-17 drive immunity to oral candidiasis via parallel mechanisms","volume":"201","author":"Verma","year":"2018","journal-title":"J. Immunol."},{"key":"2025020609280491500_r37","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/imr.12714","article-title":"Lessons from primary immunodeficiencies: autoimmune regulator and autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy","volume":"287","author":"Constantine","year":"2019","journal-title":"Immunol. Rev."},{"key":"2025020609280491500_r38","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1084\/jem.20091983","article-title":"Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I","volume":"207","author":"Puel","year":"2010","journal-title":"J. Exp. Med."},{"key":"2025020609280491500_r39","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1084\/jem.20091669","article-title":"Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines","volume":"207","author":"Kisand","year":"2010","journal-title":"J. Exp. Med."},{"key":"2025020609280491500_r40","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.coi.2021.07.011","article-title":"Infections in the monogenic autoimmune syndrome APECED","volume":"72","author":"Oikonomou","year":"2021","journal-title":"Curr. Opin. Immunol."},{"key":"2025020609280491500_r41","doi-asserted-by":"crossref","first-page":"eabi8835","DOI":"10.1126\/science.abi8835","article-title":"Response to comments on \u201cAberrant type 1 immunity drives susceptibility to mucosal fungal infections.\u201d","volume":"373","author":"Break","year":"2021","journal-title":"Science"},{"key":"2025020609280491500_r42","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1056\/NEJMoa2312665","article-title":"The role of interferon-gamma in autoimmune polyendocrine syndrome type 1","volume":"390","author":"Oikonomou","year":"2024","journal-title":"N. Engl. J. Med."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/213\/8\/1049\/61501062\/ji2400510.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/213\/8\/1049\/61501062\/ji2400510.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T09:29:32Z","timestamp":1738834172000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/213\/8\/1049\/7961032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,10,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.2400510","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,10]]},"published":{"date-parts":[[2024,10]]}}}