{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T05:25:31Z","timestamp":1755926731605,"version":"3.40.3"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1975,7,1]],"date-time":"1975-07-01T00:00:00Z","timestamp":173404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1975,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The aim of the study was to determine which cell mediates adoptive immunotherapy and chemoimmunotherapy of a syngeneic transplantable Friend virus-induced leukemia (FBL-3). An adoptive immunotherapy model was developed in which adult C57BL\/6 mice given a lethal dose (104) of FBL-3 on day 0 were saved by treatment on day 1 with C57BL\/6 spleen cells or peritoneal exudate cells (PEC) immune to FBL-3. Cells passed through a nylon wool column to remove B cells and macrophages or treated with carbonyl iron to remove phagocytic cells remained effective, whereas cells treated with anti-\u03d1 serum and complement were far less effective. For adoptive chemoimmunotherapy, mice inoculated with 107 FBL-3 were treated 5 days later with cyclophosphamide (CY) plus immune spleen cells. CY, with or without non-immune cells, prolonged survival but all mice died with leukemia, whereas mice given CY plus immune cells survived tumor-free. As an adjunct to CY, immune cells passed through nylon wool or treated with carbonyl iron remained quite effective whereas cells treated with anti-\u03d1 serum and complement were far less effective. Thus, immune thymus-derived lymphocytes were required for the adoptive immunotherapy of an early leukemia or chemoimmunotherapy of a disseminated leukemia.<\/jats:p>","DOI":"10.4049\/jimmunol.115.1.234","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T22:20:20Z","timestamp":1672438820000},"page":"234-238","source":"Crossref","is-referenced-by-count":59,"title":["Syngeneic Adoptive Immunotherapy and Chemoimmuno-therapy of a Friend Leukemia: Requirement for T cells"],"prefix":"10.1093","volume":"115","author":[{"given":"James R","family":"Berenson","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Washington School of Medicine , Seattle, Washington 98195"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Albert B","family":"Einstein","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington School of Medicine , Seattle, Washington 98195"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Fefer","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington School of Medicine , Seattle, Washington 98195"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1975,7,1]]},"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/115\/1\/234\/62499031\/ji1150010234.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/115\/1\/234\/62499031\/ji1150010234.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T11:45:13Z","timestamp":1743767113000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/115\/1\/234\/8089670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1975,7,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.115.1.234","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"type":"print","value":"0022-1767"},{"type":"electronic","value":"1550-6606"}],"subject":[],"published-other":{"date-parts":[[1975,7]]},"published":{"date-parts":[[1975,7,1]]}}}