{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T04:13:37Z","timestamp":1743480817463,"version":"3.40.3"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1978,10,1]],"date-time":"1978-10-01T00:00:00Z","timestamp":276048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1978,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The serology, immunochemistry, and genetics of the product(s) of a third H-2 locus, H-2L (previously designated D') have been studied by using an antiserum raised in BALB\/c-H-2db mutant mice against tissues from the wild type strain, BALB\/c. Genetic mapping studies and sequential immunoprecipitation experiments both indicate that this antiserum reacts specifically with L molecules. These results imply that an H-2L product is anti-genically undetectable in BALB\/c-H-2db mice and that the lesion in this mutant is confined to the H-2L and not the H-2D locus. Two new specificities, H-2.64 and H-2.65, are defined by the reactivity of anti-L serum on allogeneic cells, and the strain distribution of these specificities suggests the existence of at least three H-2L alleles. This third H-2 locus is therefore polymorphic and in view of this and other similarities to the H-2K and H-2D loci, it must be considered in any evolutionary models dealing with the origin of multiple subloci of the major histocompatibility complex.<\/jats:p>","DOI":"10.4049\/jimmunol.121.4.1469","type":"journal-article","created":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T02:33:58Z","timestamp":1672454038000},"page":"1469-1472","source":"Crossref","is-referenced-by-count":31,"title":["Isolation and Antigenic Characterization of the Product of a Third Polymorphic <i>H-2<\/i> Locus, <i>H-2L<\/i>"],"prefix":"10.1093","volume":"121","author":[{"given":"Ted H","family":"Hansen","sequence":"first","affiliation":[{"name":"Transplantation Biology Section, Immunology Branch, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 20014"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H","family":"Sachs","sequence":"additional","affiliation":[{"name":"Transplantation Biology Section, Immunology Branch, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 20014"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1978,10,1]]},"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/121\/4\/1469\/62817798\/ji1210041469.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/121\/4\/1469\/62817798\/ji1210041469.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T21:32:41Z","timestamp":1743456761000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/121\/4\/1469\/8100901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1978,10,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.121.4.1469","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"type":"print","value":"0022-1767"},{"type":"electronic","value":"1550-6606"}],"subject":[],"published-other":{"date-parts":[[1978,10]]},"published":{"date-parts":[[1978,10,1]]}}}