{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T01:18:17Z","timestamp":1760577497106,"version":"3.40.3"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1978,11,1]],"date-time":"1978-11-01T00:00:00Z","timestamp":278726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1978,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We have described a procedure for isolating thymic macrophages and have evaluated their activity in stimulating thymocyte maturation in vitro. The culturing of gradient-purified immature thymocytes on thymic macrophages leads to an increased expression of H-2 antigens and decreased lytic sensitivity with anti-TL and C. The macrophage-stimulated thymocyte also acquires the ability to respond in the MLR. We propose that the macrophage may regulate one stage of thymic differentiation in vivo.<\/jats:p>","DOI":"10.4049\/jimmunol.121.5.1861","type":"journal-article","created":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T00:01:02Z","timestamp":1672444862000},"page":"1861-1864","source":"Crossref","is-referenced-by-count":61,"title":["Thymic Macrophages Modulate One Stage of T Cell Differentiation <i>in Vitro<\/i>"],"prefix":"10.1093","volume":"121","author":[{"given":"David I","family":"Beller","sequence":"first","affiliation":[{"name":"Department of Pathology, Harvard Medical School , Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emil R","family":"Unanue","sequence":"additional","affiliation":[{"name":"Department of Pathology, Harvard Medical School , Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1978,11,1]]},"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/121\/5\/1861\/62496670\/ji1210051861.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/121\/5\/1861\/62496670\/ji1210051861.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T21:09:38Z","timestamp":1743455378000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/121\/5\/1861\/8088834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1978,11,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.121.5.1861","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"type":"print","value":"0022-1767"},{"type":"electronic","value":"1550-6606"}],"subject":[],"published-other":{"date-parts":[[1978,11]]},"published":{"date-parts":[[1978,11,1]]}}}